Biological Bases of Alcoholism

描述（由申请人提供）：该项目为博士前和博士后培训提供支持，培养能够在酒精使用障碍的病因、治疗和预防的生物学机制方面进行从分子到认知/临床水平的基础研究的专家。俄勒冈健康与科学大学（OHSU）的23名研究生在OHSU行为神经科学和神经科学研究生项目的两个研究生项目中担任博士生和博士后研究人员的导师。主要研究兴趣代表了五个共同兴趣领域：(1)酒精及其反应和风险的遗传基础，(2)酒精和药物奖励的习得和非习得决定因素，(3)酒精和其他药物的奖励和厌恶作用的神经生物学基础，(4)与乙醇依赖和敏感相关的神经适应机制，以及(5)酒精对记忆和认知的影响。技术策略反映了四个层面的分析：1 .行为药理学/药物遗传学；神经化学/神经生理/神经药理学，III。细胞/分子生物学和IV.认知神经科学/社会，包括人类/临床水平。波特兰酒精研究中心（PARC）和酒精中毒综合神经科学倡议（INIA）内的协调研究努力通过统一研究人员和创建多维研究项目加强了培训。培训包括扎实的基础科学课程基础、关于酒精和其他滥用药物的具体药理学培训，以及广泛和持续地参与研究。每年6名博士预科生，从0-2年的研究生经验开始，将获得2-3年的培训资助，然后获得个人国家研究服务奖或其导师的资源支持。每年培养3名具有0-1年博士后经验的博士后，资助期限为2年。我们有一个完善的计划来提高学员的多样性，所有学员都应该完成负责任的研究行为的初步强化课程，以及这方面的继续教育。我们的学员有充足的机会参与公众教育和外展活动。

DESCRIPTION (provided by applicant): This program for pre- and post-doctoral training supports the training of specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol use disorders. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU-Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for alcohol and responses and risk, (2) learned and unlearned determinants of alcohol and drug reward, (3) neurobiological bases for the rewarding and aversive effects of alcohol and other drugs, (4) neuroadaptive mechanisms associated with ethanol dependence and sensitization, and (5) effects of alcohol on memory and cognition. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in alcohol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 0-1 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.