Biological Bases of Alcoholism

酗酒的生物学基础

• 批准号: 8491958
• 负责人: TAMARA J. RICHARDS
• 金额: $ 43.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8491958
• 关键词: Alcoholism; Biological; base

DESCRIPTION (provided by applicant): This program for pre- and post-doctoral training supports the training of specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol use disorders. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU-Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for alcohol and responses and risk, (2) learned and unlearned determinants of alcohol and drug reward, (3) neurobiological bases for the rewarding and aversive effects of alcohol and other drugs, (4) neuroadaptive mechanisms associated with ethanol dependence and sensitization, and (5) effects of alcohol on memory and cognition. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in alcohol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 0-1 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.

说明（由申请人提供）：该博士前和博士后培训计划支持培训能够在从分子到认知/临床的各个层面上对酒精使用障碍的病因、治疗和预防的生物学机制进行基础研究的专家。俄勒冈健康与科学大学 (OHSU) 的 23 名研究生教师在 OHSU 行为神经科学和神经科学研究生项目的两个研究生项目中担任博士前学生和博士后研究员的导师。主要研究兴趣代表五个共同感兴趣的领域：（1）酒精、反应和风险的遗传基础，（2）酒精和药物奖励的习得和未习得的决定因素，（3）酒精和其他药物的奖励和厌恶作用的神经生物学基础，（4）与乙醇依赖和敏化相关的神经适应机制，以及（5）酒精对记忆和认知的影响。技术策略反映了四个层次的分析：I.行为药理学/药物遗传学，II.神经化学/神经生理学/神经药理学，III。细胞/分子生物学和IV。认知神经科学/社会，包括人类/临床水平。波特兰酒精研究中心 (PARC) 和酒精中毒综合神经科学计划 (INIA) 内部的协调研究工作通过联合研究人员和创建多维研究项目加强了培训。培训包括坚实的基础科学课程基础、酒精和其他滥用药物的具体药理学培训以及广泛和持续的研究参与。每年六名博士前培训生，从0-2年的研究生经验开始，将获得2-3年的培训补助金的支持，然后获得个人国家研究服务奖或其导师的资源支持。每年3名具有0-1年博士后经历的博士后，将获得为期2年的培训补助金。我们有一个完善的计划来提高学员的多样性，所有学员都应完成负责任的研究行为的初步强化课程以及该领域的继续教育。我们的学员有充足的机会参与公共教育和宣传。