BIOLOGICAL BASES OF ALCOHOLISM

项目摘要/摘要 这一博士后和博士后培训计划的首要目标是培养能够 进行从分子到认知/临床、生物学等层面的基础研究 酒精(乙醇)使用障碍的病因、治疗和预防的潜在机制。二十二岁 俄勒冈健康与科学大学(OHSU)的研究生教员担任 OHSU行为学院两个研究生项目的博士后和博士后研究员 神经科学和神经科学研究生项目。主要研究兴趣代表以下五个领域 共同兴趣：(1)酒精反应和风险的遗传基础，(2)已知和未知的酒精反应和风险的决定因素 酒精奖赏，(3)酒精奖赏、厌恶和神经病理效应的神经生物学基础， (4)与反复和/或发育性酒精暴露有关的神经适应机制 依赖和敏化；(5)乙醇对记忆和认知的影响。此外，与 其他滥用药物的影响令人非常感兴趣。技术战略反映了四个层次的分析：一. 行为药理学/药物遗传学，II.神经化学/神经生理学/神经药理学， 三.细胞/分子生物学和四.认知神经科学/社会，包括人类/临床层面 波特兰酒精研究中心(PARC)内的协调研究工作 关于酒精中毒的神经科学倡议(INIA)通过统一调查人员和创造 多维研究项目。培训包括扎实的基础科学基础，特别是 关于乙醇和其他滥用药物的药理学培训，并广泛和持续地参与 研究。将支持每年6名博士前实习生，从0-2年的研究生经验开始 通过2-3年的培训补助金，然后通过个人国家研究服务奖或他们的导师的 资源。每年三名具有1-3年博士后工作经验的博士后实习生将由 为期两年的培训补助金。我们有一个完善的计划，以改善我们受训人员的多样性和所有 学员还需要完成负责任的研究行为方面的初始强化课程 作为这一领域的继续教育。我们的实习生有很多机会参与公共活动 教育和外展。

Project Summary / Abstract The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty-two members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for ethanol responses and risk, (2) learned and unlearned determinants of ethanol reward, (3) neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol, (4) neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol dependence and sensitization, and (5) effects of ethanol on memory and cognition. In addition, comparison to the effects of other drugs of abuse is of significant interest. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in ethanol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 1-3 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.