BIOLOGICAL BASES OF ALCOHOLISM

项目总结/摘要 这个博士前和博士后培训计划的总体目标是培养能够 进行从分子到认知/临床、生物学和医学等层面的基础研究。 酒精（乙醇）使用障碍的病因学、治疗和预防机制。二十二 俄勒冈州健康与科学大学（OHSU）研究生教师的成员担任导师， 博士前学生和博士后研究员在两个研究生课程在OHSU行为 神经科学和神经科学研究生课程。主要研究兴趣包括五个领域， 共同兴趣：（1）乙醇反应和风险的遗传基础，（2）学习和非学习的决定因素， （3）乙醇的奖赏效应、厌恶效应和神经病理学效应的神经生物学基础; (4)与重复和/或发育性乙醇暴露相关的神经适应机制， 酒精对记忆和认知的影响。此外，与 其他滥用药物的影响也很令人感兴趣。技术策略体现了四个层次的分析：一。 行为药理学/药物遗传学，II。神经化学/神经生理学/神经药理学， 三.细胞/分子生物学和IV.认知神经科学/社会，包括人类/临床水平。 协调波特兰酒精研究中心（PARC）和综合研究中心（IARC）的研究工作。 酒精中毒神经科学倡议（INIA）通过统一调查人员和创建 多维研究项目。培训包括基础科学的坚实课程基础，具体 酒精和其他滥用药物的药理学培训，以及广泛和持续参与 research.每年将支持6名博士前培训生，从0-2年的研究生经验开始 由培训补助金2-3年，然后由个人国家研究服务奖或其导师的 资源每年3名具有1-3年博士后工作经验的博士后培训生将获得以下资助： 两年的培训补助金。我们有一个完善的计划，以提高我们的学员和所有的多样性， 受训人员还将完成一个关于负责任的研究行为的初步强化课程， 继续教育在这方面。我们的学员有充分的机会参与公共活动， 教育和推广。

Project Summary / Abstract The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty-two members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for ethanol responses and risk, (2) learned and unlearned determinants of ethanol reward, (3) neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol, (4) neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol dependence and sensitization, and (5) effects of ethanol on memory and cognition. In addition, comparison to the effects of other drugs of abuse is of significant interest. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in ethanol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 1-3 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.