BIOLOGICAL BASES OF ALCOHOLISM

酗酒的生物学基础

• 批准号: 9278931
• 负责人: Andrey E Ryabinin
• 金额: $ 47.32万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9278931
• 关键词: Alcoholism; Biological; base

Project Summary / Abstract The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty-two members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for ethanol responses and risk, (2) learned and unlearned determinants of ethanol reward, (3) neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol, (4) neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol dependence and sensitization, and (5) effects of ethanol on memory and cognition. In addition, comparison to the effects of other drugs of abuse is of significant interest. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in ethanol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 1-3 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.

项目概要/摘要 该博士前和博士后培训计划的总体目标是培养能够 在从分子到认知/临床的各个层面上进行生物学基础研究 酒精（乙醇）使用障碍的病因、治疗和预防机制。 22 俄勒冈健康与科学大学 (OHSU) 的研究生教师担任导师 OHSU 两个研究生项目的博士前学生和博士后研究员——行为 神经科学和神经科学研究生计划。主要研究兴趣代表五个领域 共同利益：(1) 乙醇反应和风险的遗传基础，(2) 已知和未获知的决定因素 乙醇奖励，（3）乙醇奖励、厌恶和神经病理学影响的神经生物学基础， (4) 与重复和/或发育性乙醇暴露相关的神经适应性机制，乙醇 依赖性和敏化，以及（5）乙醇对记忆和认知的影响。另外，比较 其他药物滥用的影响引起了人们的极大兴趣。技术策略反映了四个层面的分析： I. 行为药理学/药物遗传学，II。神经化学/神经生理学/神经药理学， 三．细胞/分子生物学和IV。认知神经科学/社会，包括人类/临床水平。 波特兰酒精研究中心 (PARC) 和综合研究中心协调研究工作 酗酒神经科学倡议 (INIA) 通过联合研究人员和创建 多维研究项目。培训包括坚实的基础科学课程基础、具体 乙醇和其他滥用药物的药理学培训，以及广泛和持续的参与 研究。每年将支持六名博士前培训生，从0-2年的研究生经验开始 通过2-3年的培训补助金，然后通过个人国家研究服务奖或其导师的资助 资源。每年资助3名具有1-3年博士后经验的博士后培训生 为期2年的培训补助金。我们有一个完善的计划来提高学员和所有人的多样性 学员还应完成负责任的研究行为的初步强化课程 作为该领域的继续教育。我们的学员有充足的机会参与公共事务 教育和外展。