Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO)

项目概要/摘要 越来越多的化学品通过农业、 现在众所周知，工业和消费品具有意想不到的功能，并且在许多情况下非常有用。 干扰人类和其他许多内分泌调节系统的令人惊讶的能力 有机体。在过去的几十年里，对这些内分泌干扰化学物质的研究 （EDC）已发展成为一个涵盖人类生物监测和 流行病学到生殖、行为和代谢的实验研究 模型系统对预测化学、绿色化学和环境的影响 补救措施。了解 EDC 的工作（无论是单独工作还是在其他领域）所需的广泛专业知识 更复杂的环境暴露，是巨大的，并且由于临床和 EDC 提出的监管问题。该领域的复杂性给这两者都带来了巨大的障碍 个人研究计划和跨学科合作的发展 解决快速发展领域中的重要问题所必需的研究举措。大多数 可以理解的是，包含 EDC 内容的机构培训计划仅侧重于以下方面的一个子集： 这些领域。缺少的是科学家走出家门的机会 课程并沉浸在短期强化课程中，为他们奠定基础 对双方职业发展至关重要的综合问题和方法 以及整个领域的情况。 利用伍兹海洋生物学实验室 (MBL) 的独特设施 Hole，马萨诸塞州，我们计划提供这样一门课程，向高级研究生开放， 来自全国各地的博士后和独立科学家。这个为期两周的课程，内分泌- 破坏性化学品：危害与机遇 (ECHO)，将使用综合方法 旨在补充和增强参与者的讲座/实验室/建模/讨论方法 研究计划，为他们提供基本概念和进展的机会 方法以及评估 EDC 造成的危害的新兴策略 曝光。该课程还将提供有关有效沟通技巧的课程，以及 与公众和媒体互动的指导。最后，它将增强 各级协作、跨学科关系的网络。

PROJECT SUMMARY/ABSTRACT Increasing numbers of chemicals that enter our daily lives through their use in agricultural, industrial, and consumer products are now known to have unexpected and, in many cases, very surprising abilities to interfere with numerous endocrine-regulated systems in humans and other organisms. Over the past few decades, research on these endocrine-disrupting chemicals (EDCs) has developed into a field that spans areas ranging from human biomonitoring and epidemiology to experimental investigations of reproductive, behavioral and metabolic consequences in model systems to predictive chemistry, green chemistry, and environmental remediation. The breadth of expertise needed to understand what EDCs do, both alone and in more environmentally complex exposures, is enormous and compounded by the clinical and regulatory issues raised by EDCs. The complexity of the field creates significant barriers both to individual research programs and in the development of cross-disciplinary collaborative research initiatives necessary to address important questions in a rapidly developing field. Most institutional training programs with EDC components focus, understandably, on just a subset of these areas. What is lacking is the opportunity for scientists to step away from their home programs and immerse themselves in an intensive short course that grounds them in the range of integrative questions and approaches essential for both for the advancement of their careers and of the field as a whole. Taking advantage of the unique facilities at the Marine Biology Laboratory (MBL) in Woods Hole, MA, we plan to offer such a course, one that is open to advanced graduate students, postdocs and independent scientists from across the country. This two-week course, Endocrine- Disrupting Chemicals: Hazards and Opportunities (ECHO), will use a combined lecture/lab/modeling/discussion approach intended to complement and enhance participants' research programs by providing them with access to advances in fundamental concepts and approaches, along with emerging strategies for assessing the hazards posed by EDC exposures. The course also will provide sessions on effective communication skills, and guidance on interactions with both the general public and the media. Finally, it will enhance networks for collaborative, cross-disciplinary relationships at all levels.