Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO)

内分泌干​​扰化学品：危害与机遇 (ECHO)

• 批准号: 10475202
• 负责人: Patricia Hunt
• 金额: $ 19.63万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475202
• 关键词: Address; Agriculture; Area; Behavioral; Biological; Biological Models; Biological Monitoring; Caliber; Chemical Exposure; Chemicals; Chemistry; Clinical; Communication; Complement; Complex; Country; Development; Discipline; Endocrine; Endocrine Disruptors; Endocrinologist; Ensure; Epidemiologist; Epidemiology; Faculty; Family; Fostering; Foundations; Future; General Population; Generations; Goals; Health; Home; Human; Immersion; Individual; Industrial Product; Institution; Investigation; Laboratories; Link; Marine Biology; Metabolic; Modeling; Monitor; Organism; Outcome; Participant; Postdoctoral Fellow; Process; Public Health; Request for Applications; Research; Research Personnel; Risk; Risk Factors; Scientist; Series; System; Targeted Research; Technology; Testing; Training; Training Programs; Visit; Wood material; analytical tool; career; career networking; consumer product; experience; exposed human population; forging; graduate student; grasp; hazard; imprint; improved; insight; interdisciplinary collaboration; laboratory curriculum; laboratory experiment; lecturer; lectures; next generation; novel; programs; rapid technique; remediation; reproductive; skills; student training; tool

PROJECT SUMMARY/ABSTRACT Increasing numbers of chemicals that enter our daily lives through their use in agricultural, industrial, and consumer products are now known to have unexpected and, in many cases, very surprising abilities to interfere with numerous endocrine-regulated systems in humans and other organisms. Over the past few decades, research on these endocrine-disrupting chemicals (EDCs) has developed into a field that spans areas ranging from human biomonitoring and epidemiology to experimental investigations of reproductive, behavioral and metabolic consequences in model systems to predictive chemistry, green chemistry, and environmental remediation. The breadth of expertise needed to understand what EDCs do, both alone and in more environmentally complex exposures, is enormous and compounded by the clinical and regulatory issues raised by EDCs. The complexity of the field creates significant barriers both to individual research programs and in the development of cross-disciplinary collaborative research initiatives necessary to address important questions in a rapidly developing field. Most institutional training programs with EDC components focus, understandably, on just a subset of these areas. What is lacking is the opportunity for scientists to step away from their home programs and immerse themselves in an intensive short course that grounds them in the range of integrative questions and approaches essential for both for the advancement of their careers and of the field as a whole. Taking advantage of the unique facilities at the Marine Biology Laboratory (MBL) in Woods Hole, MA, we plan to offer such a course, one that is open to advanced graduate students, postdocs and independent scientists from across the country. This two-week course, Endocrine- Disrupting Chemicals: Hazards and Opportunities (ECHO), will use a combined lecture/lab/modeling/discussion approach intended to complement and enhance participants' research programs by providing them with access to advances in fundamental concepts and approaches, along with emerging strategies for assessing the hazards posed by EDC exposures. The course also will provide sessions on effective communication skills, and guidance on interactions with both the general public and the media. Finally, it will enhance networks for collaborative, cross-disciplinary relationships at all levels.

项目摘要/摘要 越来越多的化学物质通过在农业中使用，进入我们日常生活 现在已知工业和消费产品具有出乎意料的意外状态，并且在许多情况下都非常 令人惊讶的能力，可以干扰人类和其他内分泌系统的众多内分泌调节系统 有机体。在过去的几十年中，研究这些干扰化学物质 （EDC）已发展成一个领域，该领域跨越了人类的生物监测和 流行病学对生殖，行为和代谢的实验研究 预测化学，绿色化学和环境的模型系统的后果 修复。专业知识的广度需要了解EDC的工作，无论是单独还是在 临床和 EDCS提出的监管问题。该领域的复杂性造成了重大障碍 个人研究计划和跨学科合作的发展 在快速发展的领域中解决重要问题所需的研究计划。最多 可以理解的是，使用EDC组件的机构培训计划仅关注 这些区域。缺乏的是科学家有机会离开家的机会 计划并沉浸在一门密集的短期课程中 综合问题和方法对他们的职业发展至关重要 和整个领域。 利用森林的海洋生物学实验室（MBL）的独特设施 马萨诸塞州霍尔，我们计划提供这样一门课程，该课程向高级研究生开放， 来自全国各地的博士后和独立科学家。这两个周的课程，内分泌 - 破坏化学物质：危害和机会（回声）将使用合并 讲座/实验室/建模/讨论方法旨在补充和增强参与者的 研究计划通过为他们提供基本概念的进步和 方法，以及评估EDC造成的危害的新兴策略 暴露。该课程还将提供有关有效沟通技巧的会议， 与公众和媒体互动的指南。最后，它将增强 各级协作，跨学科关系的网络。