Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO)

项目概要/摘要 越来越多的化学品进入我们的日常生活，通过其在农业， 工业和消费品现在已知具有意想不到的，并且在许多情况下， 干扰人类和其他动物中许多内分泌调节系统的惊人能力 有机体在过去的几十年里，对这些干扰内分泌的化学物质的研究 内分泌干扰物（EDCs）已经发展成为一个跨越从人类生物监测和 从流行病学到生殖、行为和代谢的实验研究 模型系统对预测化学、绿色化学和环境的影响 补救措施了解EDCs单独和联合使用所需的专业知识的广度 更复杂的环境暴露是巨大的，并且由于临床和 EDCs提出的监管问题。该领域的复杂性造成了重大障碍， 个人研究计划和跨学科合作的发展 在快速发展的领域中解决重要问题所需的研究举措。最 可以理解的是，包含EDC组件的机构培训计划只关注 这些地区缺少的是科学家们走出家门的机会 程序，并沉浸在一个密集的短期课程，理由他们在范围 综合性的问题和方法对他们的职业发展都至关重要 和整个领域的影响。 利用伍兹海洋生物实验室（MBL）的独特设施 霍尔，MA，我们计划提供这样一门课程，一门对高级研究生开放的课程， 来自全国各地的博士后和独立科学家。这两周的课程，内分泌- 破坏性化学品：危险和机会（ECHO）将使用一个综合的 讲座/实验/建模/讨论方法，旨在补充和提高参与者的 研究计划，为他们提供获得基本概念的进步， 方法，沿着评估EDC危害的新兴策略 暴露。该课程还将提供有效沟通技巧的课程， 指导与公众和媒体的互动。最后，它将增强 在各级建立跨学科合作关系网络。

PROJECT SUMMARY/ABSTRACT Increasing numbers of chemicals that enter our daily lives through their use in agricultural, industrial, and consumer products are now known to have unexpected and, in many cases, very surprising abilities to interfere with numerous endocrine-regulated systems in humans and other organisms. Over the past few decades, research on these endocrine-disrupting chemicals (EDCs) has developed into a field that spans areas ranging from human biomonitoring and epidemiology to experimental investigations of reproductive, behavioral and metabolic consequences in model systems to predictive chemistry, green chemistry, and environmental remediation. The breadth of expertise needed to understand what EDCs do, both alone and in more environmentally complex exposures, is enormous and compounded by the clinical and regulatory issues raised by EDCs. The complexity of the field creates significant barriers both to individual research programs and in the development of cross-disciplinary collaborative research initiatives necessary to address important questions in a rapidly developing field. Most institutional training programs with EDC components focus, understandably, on just a subset of these areas. What is lacking is the opportunity for scientists to step away from their home programs and immerse themselves in an intensive short course that grounds them in the range of integrative questions and approaches essential for both for the advancement of their careers and of the field as a whole. Taking advantage of the unique facilities at the Marine Biology Laboratory (MBL) in Woods Hole, MA, we plan to offer such a course, one that is open to advanced graduate students, postdocs and independent scientists from across the country. This two-week course, Endocrine- Disrupting Chemicals: Hazards and Opportunities (ECHO), will use a combined lecture/lab/modeling/discussion approach intended to complement and enhance participants' research programs by providing them with access to advances in fundamental concepts and approaches, along with emerging strategies for assessing the hazards posed by EDC exposures. The course also will provide sessions on effective communication skills, and guidance on interactions with both the general public and the media. Finally, it will enhance networks for collaborative, cross-disciplinary relationships at all levels.