Biomarker Core
生物标志物核心
基本信息
- 批准号:10409747
- 负责人:
- 金额:$ 40.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:Algorithmic AnalysisAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer’s disease biomarkerAmyloid beta-42Amyloid beta-ProteinBioinformaticsBiological AssayBiological MarkersBiologyBloodBlood CellsCardiovascular DiseasesCellsClinicalClinical ManagementCollectionCytometryDNADataData AnalysesData SetDatabasesDementiaDetectionDevelopmentDiabetes MellitusDiseaseEquipment and supply inventoriesFecesFibroblastsGene ExpressionGeneticGlial Fibrillary Acidic ProteinGoalsHumanImageImmuneIndividualInformation DisseminationLeadLightLiquid substanceMeasurementMeasuresMethodsMissionMolecularNerve DegenerationNeurodegenerative DisordersParkinson DiseaseParkinson&aposs DementiaParticipantPathologic ProcessesPeripheral Blood Mononuclear CellPhenotypePlasmaPopulations at RiskProcessProteomeProteomicsPublishingQuality ControlRNAReproducibilityResearchResearch PersonnelSamplingSensitivity and SpecificitySignal TransductionSkinSourceStandardizationT-Cell ReceptorTechnologyTimeTissuesTraining SupportWorkanalysis pipelinebasebioinformatics toolbiomarker performancedata managementdata sharingexperiencegenetic variantgut microbiomeimaging modalitymembermicrobiomemolecular markermultiple omicsneurofilamentneuropathologynext generationnovelnovel markernovel therapeuticspublic databasereceptor expressionresearch studyskin microbiomestool sampletau Proteinstau-1tissue biomarkerstooltranscriptometranscriptome sequencingtranscriptomicsweb portalwhole genome
项目摘要
1. SUMMARY (Biomarker Core)
Biomarkers have enormous value for the detection, management, and treatment of disease, but also for the
development of novel therapeutics. The utility of biomarkers is most evident in the management of
cardiovascular disease and diabetes, but biomarkers, especially predictive, easily obtainable ones, are still
largely absent with respect to neurodegenerative diseases. The best fluid biomarkers currently available for
Alzheimer’s disease (AD) include; Aβ, tau, and neurofilament in CSF, a biofluid which is difficult to collect in
healthy, at-risk populations or on a repeated basis. Other biomarkers for AD include imaging modalities which
are often very expensive or have low sensitivity and specificity at the individual level. The members of this core
have considerable experience in unbiased multi-omic screens and data analysis and, over the years, have
published numerous studies towards developing new biomarkers for neurodegenerative and other diseases.
Enabled by the current ADRC, the core leaders and collaborators have used biospecimens from Stanford
ADRC participants and generated extensive preliminary data with unbiased deep immune phenotyping,
proteomics, and transcriptomics of human CSF resident cells, and discovered novel Parkinson's disease (PD)
biomarkers. Based on this expertise, the mission of this Biomarker Core is to facilitate the discovery of novel
biomarkers for AD and PD, as well as new biology underlying the pathological processes that lead to dementia
in line with the core mission of the NAPA. This will be achieved by pursuing the collection of genetic and
molecular measurements from a broad source of tissues from ADRC participants; the processing and
dissemination of this information in useable formats through web portals and other means (i.e., “Deep
Phenotyping Database”); the analysis and bioinformatics integration of the collected information with clinical
and imaging data, as well as information from public databases; and the development and dissemination of
new data analysis algorithms and pipelines.
1. 概述(生物标志物核心)
项目成果
期刊论文数量(0)
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TONY WYSS-CORAY其他文献
TONY WYSS-CORAY的其他文献
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{{ truncateString('TONY WYSS-CORAY', 18)}}的其他基金
2023 Biology of Aging Gordon Research Conference and Gordon Research Seminar
2023年衰老生物学戈登研究会议暨戈登研究研讨会
- 批准号:
10675884 - 财政年份:2023
- 资助金额:
$ 40.06万 - 项目类别:
Targeting CD22 to Restore Brain Homeostasis in Alzheimer's Disease
靶向 CD22 恢复阿尔茨海默氏病的大脑稳态
- 批准号:
10234488 - 财政年份:2019
- 资助金额:
$ 40.06万 - 项目类别:
Microglial dysfunction in brain aging and Alzheimer's disease
大脑衰老和阿尔茨海默病中的小胶质细胞功能障碍
- 批准号:
9911972 - 财政年份:2019
- 资助金额:
$ 40.06万 - 项目类别: