BLR&D Research Career Scientist Award Application

BLR

• 批准号: 9764096
• 负责人: TONY WYSS-CORAY
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9764096
• 关键词: Affect; Age; Aging; Alzheimer' s Disease; Award; Biology of Aging; Blood; Brain; Cells; Chemicals; Community Health; Dementia; Diet Modification; Disease; Environment; Exercise; Factor V; Funding Agency; Genetic study; Goals; Health Professional; Healthcare; Healthcare Systems; Human; Immune system; Impaired cognition; Incidence; Individual; Industry; Inflammation; Intervention; Killifishes; Label; Lead; Link; Longevity; Molecular; Mus; Muscle; Nerve Degeneration; Neurodegenerative Disorders; Organ; Organism; Parabiosis; Parkinson Disease; Patients; Phenotype; Physiological; Plasma; Prevalence; Process; Program Development; Proteins; Proteomics; Recombinant Inbred Strain; Research; Risk Factors; Rodent; Scientist; Stem cells; Testing; Time; Tissues; Veterans; Woman; age group; age related; aging brain; aging population; base; career; cell type; interest; men; microbiome; next generation sequencing; novel; programs; senescence; statistics; targeted treatment; therapeutic target; transcriptome

Currently, there are no treatments with significant disease modifying impact for major neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. These diseases, even in their rare, autosomal dominant forms, are age-dependent, with age presenting the key risk factor for all sporadic forms of disease. Because the aging brain becomes increasingly vulnerable to neurodegeneration, slowing or reversing aspects of aging could therefore have a tremendous impact on the incidence and prevalence of these diseases. With a rapidly aging population, including aging Veterans pushing the boundaries of what our health care systems can absorb, there has been an unprecedented interest in aging and longevity from the public, funding agencies, and industry. Interestingly, studies of rodents and humans suggest that interventions targeted to individual organs or tissues, including muscle (e.g. through exercise), gut (e.g. through modifications of diet and the microbiome), and immune system (e.g. by reducing inflammation), can affect organismal aging. But how these organs may regulate aging processes is unknown. Dr. Wyss-Coray’s discoveries along with those of others indicate that the phenotypic age of individual organs is malleable and can be altered by exposing the organism to the systemic environment of an organism of a different age through heterochronic parabiosis or plasma transfer. Unexpectedly, Wyss-Coray recently found that heat-labile factors in blood plasma from young mice or young humans are sufficient to slow or reverse brain aging in mice. Conversely, factors in plasma from old mice or old humans can accelerate aspects of brain aging and cognitive impairment in mice. These surprising observations point in a new direction and prompted Dr. Wyss-Coray to study brain aging from a physiological, top-down perspective. Dr. Wyss-Coray is using chemical, bio-orthogonal manipulation of organisms, cutting edge proteomics, and next generation sequencing to answer how young blood revitalizes the old brain at the molecular level and to harness these processes towards reversing age-related changes and Alzheimer’s disease in the human brain. The goal of these studies is to develop new treatments for Veterans and patients with neurodegenerative diseases.

目前，还没有对重大疾病有显著改善作用的治疗方法