Center for Clinical and Translational Research

联系PD/PI：Moeller，Frederick Gerard 弗吉尼亚联邦大学(VCU)临床与转化研究中心(CCTR) 促进临床和转化性研究(CTR)，将研究进展从基础科学转移到 临床实践，提高临床研究的质量和效率。在过去的5年里， CCTR已成为VCU临床和翻译研究环境的关键组成部分。它的价值 CCTR在推进临床研究方面的作用得到了超过4300万美元的机构资金的证明 支持，包括最近捐赠1600万美元将CCTR更名为C.Kenneth和Dianne Wright Center 临床和转译研究。此外，CCTR是CTSA资助的弗吉尼亚州唯一的枢纽， 促进全州和全国在人类受试者领域的临床和转译研究方面的合作 保护和招募、社区参与、团队科学、信息学和科学审查。 CCTR的总体战略目标是通过以下计划和流程促进CTR 质量和效率，研究和临床实践相结合，为发展CTR提供培训 劳动力。这一目标将与CTSA网络合作实现，并在VCU和我们的 地方、区域和国家的伙伴机构，下文将详细说明每个总体目标。 跨核心的一个重要主题是处理、分析、挖掘、集成和 共享大型数据集。 总体目标1：以经验为基础促进翻译研究队伍发展 信息学、团队科学、生物统计学、研究设计和监管科学方面的培训，分享 与CTSA网络在最佳教育做法方面进行合作，以培养下一代 CTR科学家。 总体目标2：调动社区参与和团队科学方面的现有优势，以 让利益相关者社区在每个翻译阶段成为研究合作伙伴并形成 协作型临床转化科学团队。 总体目标3：通过以下方式，在特殊人群中整合全寿命周期内所有阶段的CTR 增加枢纽和网络研究能力，并与相关提供者、患者、 护理者和其他利益相关者，以指导研究、护理和招聘。 总体目标4：推进临床和转化性研究方法和流程，以加快 在VCU内部和与CTSA网络进行翻译、建立协作和优化资源。 总体目标5：实施信息系统以集成多种类型的数据以获得洞察力 研究疾病和机制，加强培训，收集衡量标准以提高绩效和 测量影响，并通过CCTR和CTSA网络将研究与临床实践联系起来。 项目摘要/摘要页227 联系PD/PI：Moeller，Frederick Gerard 正如医学研究所(IOM)关于CTSA计划的报告中所描述的那样，尽管有一个 在过去的50年里，美国的生物医学研究呈指数级增长，将研究结果转化为 从基础和临床研究到临床实践都存在不足。在接下来的5年资金中，CCTR 建议充分利用特殊患者群体、社区参与度、劳动力方面的优势 发展和信息学，以扩大与CTSA网络的联系，以促进创新 方法、流程和培训，侧重于交付高质量的临床和转化性研究。在……里面 此外，利用生物医学信息学工具，CCTR将促进医疗保健和 在VCU内部以及全州和全国合作伙伴之间进行研究。

Contact PD/PI: MOELLER, FREDERICK Gerard The Center for Clinical and Translational Research (CCTR) at Virginia Commonwealth University (VCU) promotes clinical and translational research (CTR), moving research advances from basic science into clinical practice, and improving the quality and efficiency of clinical research. Over the last 5 years the CCTR has become a critical component of VCU’s clinical and translational research environment. The value placed on the CCTR’s role in advancing clinical research is evidenced by over $43,000,000 of institutional support, including a recent $16 million gift to rename the CCTR the C. Kenneth and Dianne Wright Center for Clinical and Translational Research. In addition, the CCTR serves as the only CTSA funded hub in Virginia, fostering statewide and national collaborations in clinical and translational research in areas of human subjects protection and recruitment, community engagement, team science, informatics, and scientific review. The overall CCTR strategic goal is to catalyze CTR through programs and processes that enhance quality and efficiency, integrate research and clinical practice, and provide training to develop the CTR workforce. This goal will be achieved in collaboration with the CTSA Network and implemented at VCU and our partner institutions locally, regionally, and nationally, as described in detail related to each overall aim below. An important theme across cores is innovation in methods for processing, analysis, mining, integrating, and sharing of large data sets. Overall Aim 1: Promote translational research workforce development with experience based training in informatics, team science, biostatistics, research design, and regulatory science, sharing and collaborating with the CTSA Network in best educational practices to develop the next generation of CTR scientists. Overall Aim 2: Mobilize existing strengths in community engagement and team science to engage stakeholder communities at every translational phase to become research partners and form collaborative clinical translational science teams. Overall Aim 3: Integrate all phases of CTR across the lifespan and in special populations by increasing hub and network research capacity and connecting with relevant providers, patients, caregivers, and other stakeholders to guide research, care, and recruitment. Overall Aim 4: Advance clinical and translational research methods and processes to speed translation, build collaborations, and optimize resources within VCU and with the CTSA Network. Overall Aim 5: Implement informatics systems to integrate multiple types of data to gain insight into diseases and mechanisms, to enhance training, to collect metrics to improve performance and gauge impact, and to bridge research to clinical practice across the CCTR and the CTSA Network. Project Summary/Abstract Page 227 Contact PD/PI: MOELLER, FREDERICK Gerard As described in the Institute of Medicine (IOM) report on the CTSA program, although there has been an exponential increase in biomedical research in the United States in the last 50 years, translating the findings from basic and clinical research to clinical practice has fallen short. For the next 5 years of funding, the CCTR proposes to capitalize on strengths in a special patient population, community engagement, workforce development, and informatics, to expand connections with the CTSA network to promote innovation in methods, processes, and training, focused on the delivery of high quality clinical and translational research. In addition, utilizing biomedical informatics tools, the CCTR will promote a greater integration of healthcare and research within VCU and across statewide and national partners.