Training Program in Quantitative Biology & Physiology (QBP)

定量生物学培训计划

• 批准号: 10410989
• 负责人: John A. White
• 金额: $ 52.04万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410989
• 关键词: Biology; Physiology; Training Programs

De novo funding is requested to build on the success of an existing training program entitled Quantitative Biology and Physiology (QBP) with enhancements and new elements. The core mission of this program will be to train PhD research scientists who demonstrate: (1) a quantitatively-based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the ability to apply advanced techniques of computational modeling and quantitative measurement to understand biological and physiological systems; (3) the capacity to determine emergent properties biological systems or processes across length scales; and (4) the insight to apply their knowledge, in an academic or industrial setting, in order to improve human health. The QBP program includes the following crucial features (new features underlined): A large and extraordinarily talented and diverse pool of BME PhD matriculants from which trainees will be chosen; to promote a diverse class, an explicit policy that the GREs are not a criterion for admission to the QBP training program; a carefully curated list of 34 training faculty; a request to increase the number of NIH-funded slots to 12 with a commitment from the BU BME department to fund an additional two trainees each year; an integrated structure of governance that includes student and faculty representatives; robust data collection and a dashboard display, as well as more detailed surveys and interviews of trainees, begun with support from a T32 supplement; rigorous training for mentors and mentees throughout the lifetime of this program; a well-considered curriculum that includes rigorous training in quantitative biology at multiple scales, scale- independent analysis and modeling, and multi-scale measurement techniques; a new, highly successful elective course in Machine Learning for BME applications; multiple lab rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at the molecular, cellular- tissue, and organ-level biology and physiology; opportunities to conduct thesis research that is interdisciplinary, quantitative, integrative, and necessarily linked to experimental and/or clinical data; training and incentives for trainees to apply for and receive independent funding; for students after the first and fourth years of PhD training, a summer retreat covering regulatory issues, supplemental training in ethics, and preparation for research and leadership careers after graduation; successful culture-building efforts, including a journal club and a yearly symposium; dinners each year with clinical and academic thought leaders; and continual improvement of successful efforts to increase the size of the pool and the yield of candidates from underrepresented minorities and those with disabilities or from disadvantaged backgrounds. In summary, the requested funding will support a program of diverse excellence that fills a unique niche in America’s research infrastructure.

要求从头提供资金，以便在现有的题为“量化”的培训方案的基础上再接再厉 生物学和生理学(QBP)，具有增强和新元素。这项计划的核心任务是 将培训具有以下特点的博士生研究科学家：(1)对 分子生物学、细胞生物学和生理学的基本原理；(2)应用先进的 用计算建模和定量测量技术来理解生物学和 生理系统；(3)确定紧急性质、生物系统或过程的能力 以及(4)在学术或工业环境中应用其知识的洞察力 以改善人类健康。 QBP计划包括以下关键功能(带下划线的新功能)：大型和 非常有才华和多样化的BME博士预科生人才库将从中挑选受训者； 促进班级多样化，明确规定GRE不是QBP培训的录取标准 计划；一份精心挑选的34名培训教师的名单；要求增加NIH资助的职位数量 至12人，BU BME部门承诺每年再资助两名学员； 包括学生和教职员工代表在内的综合治理结构；可靠的数据收集 和仪表板展示，以及对受训人员的更详细的调查和访谈，从支持开始 来自T32附录；在本计划的整个生命周期内对导师和学员进行严格的培训；a 经过深思熟虑的课程，包括在多个级别上进行严格的数量生物学培训，规模- 独立的分析和建模以及多尺度测量技术；一种新的、非常成功的 用于BME应用的机器学习选修课；多个实验室轮换，确保接触到 定量和系统/动力学研究技术与分子、细胞- 组织和器官水平的生物学和生理学；进行论文研究的机会 跨学科的、定量的、综合的、必须与实验和/或临床数据相联系的；培训 对学员申请和获得独立资助的奖励；对第一和第四年后的学生 多年的博士培训，涵盖监管问题的夏季静修，道德方面的补充培训，以及 为毕业后的研究和领导生涯做准备；成功的文化建设努力， 包括一个期刊俱乐部和一个年度研讨会；每年带着临床和学术思想的晚餐 领导；以及不断改进成功的努力，以扩大资金池的规模和产量 来自代表性不足的少数群体和残疾人或弱势背景的候选人。 总而言之，申请的资金将支持一个多样化的卓越计划，该计划填补了 美国的研究基础设施。