Training Program in Quantitative Biology & Physiology (QBP)

定量生物学培训计划

• 批准号: 10410989
• 负责人: John A. White
• 金额: $ 52.04万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410989
• 关键词: Biology; Physiology; Training Programs

De novo funding is requested to build on the success of an existing training program entitled Quantitative Biology and Physiology (QBP) with enhancements and new elements. The core mission of this program will be to train PhD research scientists who demonstrate: (1) a quantitatively-based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the ability to apply advanced techniques of computational modeling and quantitative measurement to understand biological and physiological systems; (3) the capacity to determine emergent properties biological systems or processes across length scales; and (4) the insight to apply their knowledge, in an academic or industrial setting, in order to improve human health. The QBP program includes the following crucial features (new features underlined): A large and extraordinarily talented and diverse pool of BME PhD matriculants from which trainees will be chosen; to promote a diverse class, an explicit policy that the GREs are not a criterion for admission to the QBP training program; a carefully curated list of 34 training faculty; a request to increase the number of NIH-funded slots to 12 with a commitment from the BU BME department to fund an additional two trainees each year; an integrated structure of governance that includes student and faculty representatives; robust data collection and a dashboard display, as well as more detailed surveys and interviews of trainees, begun with support from a T32 supplement; rigorous training for mentors and mentees throughout the lifetime of this program; a well-considered curriculum that includes rigorous training in quantitative biology at multiple scales, scale- independent analysis and modeling, and multi-scale measurement techniques; a new, highly successful elective course in Machine Learning for BME applications; multiple lab rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at the molecular, cellular- tissue, and organ-level biology and physiology; opportunities to conduct thesis research that is interdisciplinary, quantitative, integrative, and necessarily linked to experimental and/or clinical data; training and incentives for trainees to apply for and receive independent funding; for students after the first and fourth years of PhD training, a summer retreat covering regulatory issues, supplemental training in ethics, and preparation for research and leadership careers after graduation; successful culture-building efforts, including a journal club and a yearly symposium; dinners each year with clinical and academic thought leaders; and continual improvement of successful efforts to increase the size of the pool and the yield of candidates from underrepresented minorities and those with disabilities or from disadvantaged backgrounds. In summary, the requested funding will support a program of diverse excellence that fills a unique niche in America’s research infrastructure.

要求重新提供资金，以便在现有培训方案“定量”的成功基础上再接再厉， 生物学和生理学（QBP）与增强和新的元素。这个项目的核心使命 将培养博士研究科学家谁证明：（1）基于定量的理解， 分子生物学、细胞生物学和生理学的基本原理;（2）应用先进的 计算建模和定量测量技术，以了解生物和 生理系统;（3）确定生物系统或过程的紧急特性的能力 （4）在学术或工业环境中应用知识的洞察力， 以改善人类健康。 QBP计划包括以下关键功能（新功能下划线）： 非常有才华和多样化的BME博士预科生池，学员将从中选择; 促进多样化的班级，明确规定GRE不是QBP培训的录取标准 计划;精心策划的34名培训教师的名单;增加NIH资助名额的请求 由BU BME部门承诺每年额外资助两名受训人员; 综合治理结构，包括学生和教师代表;强大的数据收集 和仪表板显示，以及更详细的调查和学员访谈，开始与支持 从T32补充;严格的培训导师和学员在整个生命周期的这个计划; 经过深思熟虑的课程，包括在多个尺度，规模， 独立的分析和建模，以及多尺度测量技术;一个新的，非常成功的 BME应用程序机器学习选修课程;多次实验室轮换，确保接触 定量和系统/动力学研究技术有关的问题，在分子，细胞， 组织和器官水平的生物学和生理学;进行论文研究的机会， 跨学科、定量、综合，并与实验和/或临床数据有必要联系;培训 鼓励学员申请和接受独立资助; 多年的博士培训，涵盖监管问题的夏季务虚会，道德方面的补充培训，以及 为毕业后的研究和领导职业做准备;成功的文化建设努力， 包括期刊俱乐部和年度研讨会;每年与临床和学术思想共进晚餐 领导人;不断改进成功的努力，以增加池的规模和产量， 来自代表性不足的少数民族和残疾人或来自弱势背景的候选人。 总之，所要求的资金将支持一个多样化的卓越计划，填补了一个独特的利基， 美国的研究基础设施。