Training Program in Quantitative Biology & Physiology (QBP)

定量生物学培训计划

• 批准号: 10621225
• 负责人: John A. White
• 金额: $ 53.05万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621225
• 关键词: Biology; Physiology; Training Programs

De novo funding is requested to build on the success of an existing training program entitled Quantitative Biology and Physiology (QBP) with enhancements and new elements. The core mission of this program will be to train PhD research scientists who demonstrate: (1) a quantitatively-based understanding of the principles underlying molecular biology, cell biology and physiology; (2) the ability to apply advanced techniques of computational modeling and quantitative measurement to understand biological and physiological systems; (3) the capacity to determine emergent properties biological systems or processes across length scales; and (4) the insight to apply their knowledge, in an academic or industrial setting, in order to improve human health. The QBP program includes the following crucial features (new features underlined): A large and extraordinarily talented and diverse pool of BME PhD matriculants from which trainees will be chosen; to promote a diverse class, an explicit policy that the GREs are not a criterion for admission to the QBP training program; a carefully curated list of 34 training faculty; a request to increase the number of NIH-funded slots to 12 with a commitment from the BU BME department to fund an additional two trainees each year; an integrated structure of governance that includes student and faculty representatives; robust data collection and a dashboard display, as well as more detailed surveys and interviews of trainees, begun with support from a T32 supplement; rigorous training for mentors and mentees throughout the lifetime of this program; a well-considered curriculum that includes rigorous training in quantitative biology at multiple scales, scale- independent analysis and modeling, and multi-scale measurement techniques; a new, highly successful elective course in Machine Learning for BME applications; multiple lab rotations that ensure exposure to quantitative and systems/dynamics research techniques relevant to problems at the molecular, cellular- tissue, and organ-level biology and physiology; opportunities to conduct thesis research that is interdisciplinary, quantitative, integrative, and necessarily linked to experimental and/or clinical data; training and incentives for trainees to apply for and receive independent funding; for students after the first and fourth years of PhD training, a summer retreat covering regulatory issues, supplemental training in ethics, and preparation for research and leadership careers after graduation; successful culture-building efforts, including a journal club and a yearly symposium; dinners each year with clinical and academic thought leaders; and continual improvement of successful efforts to increase the size of the pool and the yield of candidates from underrepresented minorities and those with disabilities or from disadvantaged backgrounds. In summary, the requested funding will support a program of diverse excellence that fills a unique niche in America’s research infrastructure.

请求从头提供资金，以建立题为“定量”的现有培训计划的成功基础。 生物学和生理学 (QBP) 具有增强功能和新元素。该计划的核心使命 将培养博士研究科学家，他们表现出：（1）对 分子生物学、细胞生物学和生理学的基础原理； (2)先进的应用能力 计算建模和定量测量技术来了解生物和 生理系统； (3) 确定生物系统或过程的突发特性的能力 跨长度尺度； (4) 在学术或工业环境中应用其知识的洞察力 以改善人类健康。 QBP 计划包括以下重要功能（新功能下划线）： 才华横溢且多元化的 BME 博士预科生库，将从中挑选学员；到 促进多元化的班级，明确的政策是 GRE 成绩不是 QBP 培训录取的标准 程序;精心挑选的 34 名培训教师名单；请求增加 NIH 资助的名额数量 BU BME 部门承诺每年资助另外两名学员，将学员人数增至 12 人；一个 包括学生和教师代表在内的综合治理结构；强大的数据收集 和仪表板显示，以及对受训者进行更详细的调查和访谈，从支持开始 来自 T32 补充剂；在该计划的整个生命周期中对导师和受训者进行严格的培训；一个 经过深思熟虑的课程，包括多尺度定量生物学的严格培训 独立分析和建模以及多尺度测量技术；一个新的、非常成功的 BME 应用机器学习选修课程；多次实验室轮换，确保暴露于 与分子、细胞问题相关的定量和系统/动力学研究技术 组织和器官水平的生物学和生理学；进行论文研究的机会 跨学科、定量、综合，并且与实验和/或临床数据有必然联系；训练 鼓励学员申请和获得独立资助；对于第一和第四之后的学生 多年的博士培训、涵盖监管问题的暑期静修、道德方面的补充培训，以及 毕业后为研究和领导职业做好准备；成功的文化建设努力， 包括期刊俱乐部和年度研讨会；每年都有临床和学术思想的晚餐 领导者；并不断改进扩大资金池规模和产量的成功努力 来自代表性不足的少数群体以及残疾人或弱势背景的候选人。 总之，所请求的资金将支持一个多元化的卓越计划，该计划填补了一个独特的领域 美国的研究基础设施。