Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)

器官退化和再生的神经控制培训（NeuralCODR）

• 批准号: 10410250
• 负责人: Philip J Horner
• 金额: $ 17.66万
• 依托单位: METHODIST HOSPITAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410250
• 关键词: Natural regeneration; Organ; Training; neuroregulation

Neural activity directly controls the development and homeostasis of organ function. Yet, a surprising gap exists between laboratories focused on vascular, gastrointestinal, immune, and musculoskeletal systems and those focused on neurophysiology, neuromodulation, and neural injury. Traditionally, departments are organized by organ system and this siloed structure leads to a physical and scientific jargon separation, impeding collaboration and training. Hence, our understanding of how the central nervous system communicates with end organs throughout the body is in its infancy. Neural Control of Organ Degeneration and Regeneration (NeuralCODR), a cross-disciplinary training program unites 30 faculty members and 12 clinician researchers to form mentorship teams within the largest medical research center in the world (Texas Medical Center). Mentorship teams include a primary and secondary mentor (each from one of our three main areas of research: 1) neural development and tools, 2) neural innervation and organ engineering, and 3) nervous system and peripheral organ disorders) and a clinical mentor who provides much needed and rare exposure to real-world diseases, clinical challenges, and human samples. NeuralCODR aims to: 1) catalyze the collision of talent and ideas that spawn research projects bridging neuroscience with organ systems through facilitated interactions, 2) build co-mentor teams that include neuroscience, organ systems, and clinical perspectives, ensuring trainees are guided toward a unique research niche, and 3) train fellows in research rigor, analysis, and career skills that support their development as scientific leaders. NeuralCODR leverages a network of faculty who collaborate on projects that bridge the gap between organ system biology and engineering and neural function, degeneration and regeneration, as evidenced by an impressive list of multi-laboratory shared grants, publications, and nascent collaborations. The training structure emphasizes experiences in organ engineering and organ physiology laboratories in parallel with education in neurophysiology and neural engineering, translational theory, and practice. Currently, two NeuralCODR Houston Methodist-specific postdoctoral positions exist, thanks to a philanthropic endowment that has allowed us to build the program structure and to test both the coursework and mentorship team concept. Trainees are funded for two years, during which time they have access to a core curriculum, career development and program enrichment opportunities, symposiums/retreats, and elective courses. Year one culminates with the submission of an NRSA and a manuscript based on trainees’ development of a transformative research project that incorporates non-neuroscience expertise and tools into a neuroscience problem. Year two solidifies the relationships between the mentorship team and trainee and provides training in laboratory management, didactic teaching, and mentorship skills. T32 funding will allow us to increase the current model to six postdoctoral training slots. This training program will foster a new generation of scientific leaders who pioneer research on the connected pathways between brain and organ systems to solve fundamental challenges in neuroscience.

神经活动直接控制器官功能的发育和稳态。然而， 专注于血管、胃肠道、免疫和肌肉骨骼系统的实验室之间， 专注于神经生理学、神经调节和神经损伤。传统上，部门由 器官系统和这种孤立的结构导致了物理和科学术语的分离，阻碍了合作 和培训及其有效因此，我们对中枢神经系统如何与终末器官交流的理解 还处于幼年期器官退化和再生的神经控制（NeuralCODR） 跨学科培训计划联合30名教师和12名临床研究人员，形成导师制 世界上最大的医学研究中心（德克萨斯医学中心）的团队。导师团队包括 一个主要和次要的导师（每个人都来自我们的三个主要研究领域之一：1）神经发育， 工具，2）神经支配和器官工程，和3）神经系统和外周器官病症）和 一个临床导师谁提供急需和罕见的接触现实世界的疾病，临床挑战， 人体样本NeuralCODR旨在：1）促进人才和思想的碰撞，催生研究项目 通过促进互动将神经科学与器官系统联系起来，2）建立共同导师团队，包括 神经科学，器官系统和临床观点，确保学员被引导到一个独特的研究 利基，以及3）在研究严谨性，分析和职业技能，支持他们的发展，科学研究员培训 领导人的人选信号NeuralCODR利用教师网络，他们在项目上合作，弥合差距 器官系统生物学和工程学以及神经功能、退化和再生，如一个 令人印象深刻的多实验室共享赠款、出版物和新生合作清单。培养结构 强调在器官工程和器官生理学实验室的经验与教育平行， 神经生理学和神经工程，转化理论和实践。目前，两个NeuralCODR休斯顿 卫理公会特定的博士后职位存在，感谢慈善捐赠，使我们能够建立 课程结构，并测试课程和指导团队的概念。培训人员获得资助， 两年，在此期间，他们可以获得核心课程，职业发展和计划 丰富的机会，研讨会/务虚会，和选修课程。第一年的高潮是提交 一个NRSA和手稿的基础上学员的发展一个变革性的研究项目， 将非神经科学的专业知识和工具融入神经科学问题。第二年巩固了 指导团队和学员之间的关系，并提供实验室管理，教学 教学和指导技能。T32资助将使我们能够将目前的博士后培养模式增加到6个 slots.这项培训计划将培养新一代的科学领导者，他们将开拓研究领域， 连接大脑和器官系统之间的通路，以解决神经科学中的基本挑战。