Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)

神经活动直接控制器官功能的发育和动态平衡。然而，存在着一个令人惊讶的差距 在专注于血管、胃肠、免疫和肌肉骨骼系统的实验室和 重点研究神经生理学、神经调节和神经损伤。传统上，部门的组织方式是 器官系统和这种孤立的结构导致物理和科学术语的分离，阻碍了合作 和训练。因此，我们对中枢神经系统如何与末端器官沟通的理解 全身都处于婴儿期。器官退化和再生的神经控制(NeuralCODR)，a 跨学科培训计划将30名教职员工和12名临床研究人员联合起来，形成导师关系 世界上最大的医学研究中心(德克萨斯医学中心)内的团队。导师团队包括 一名初级和二级导师(分别来自我们三个主要研究领域之一：1)神经发展和 工具，2)神经神经和器官工程，以及3)神经系统和外周器官疾病)和 临床导师，提供急需且难得的接触真实世界疾病、临床挑战和 人体样本。NeuralCODR的目标是：1)催化人才和思想的碰撞，催生研究项目 通过促进互动将神经科学与器官系统联系起来，2)建立共同指导团队，包括 神经科学、器官系统和临床视角，确保学员被引导进行独特的研究 利基市场，以及3)培训研究员的研究严谨性、分析和职业技能，以支持他们的科学发展 领袖们。NeuralCODR利用一个教职员工网络，他们在项目上进行合作，弥合 器官系统生物学和工程学以及神经功能、退化和再生，如 令人印象深刻的多个实验室共享的赠款、出版物和新生的合作项目。培训结构 强调器官工程和器官生理学实验室的经验，同时也强调 神经生理学和神经工程学，翻译理论和实践。目前，休斯顿的两个NeuralCODR 卫理公会特定的博士后职位存在，这要归功于一项慈善捐赠，这使得我们能够建立 该计划的结构和测试的课程工作和导师团队的概念。受训人员将获得以下资助 两年，在此期间，他们可以获得核心课程、职业发展和计划 丰富的机会、座谈会/务虚会和选修课。第一年的高潮是提交 NRSA和一份基于受训者开发的变革性研究项目的手稿 将非神经科学的专业知识和工具结合到神经科学问题中。第二年巩固了 指导团队和学员之间的关系，并提供实验室管理方面的培训 教学和指导技能。T32资金将使我们将目前的模式增加到6个博士后培训 老虎机。这一培训计划将培养新一代科学领军人物，他们开创了 大脑和器官系统之间的连接路径，以解决神经科学中的根本挑战。

Neural activity directly controls the development and homeostasis of organ function. Yet, a surprising gap exists between laboratories focused on vascular, gastrointestinal, immune, and musculoskeletal systems and those focused on neurophysiology, neuromodulation, and neural injury. Traditionally, departments are organized by organ system and this siloed structure leads to a physical and scientific jargon separation, impeding collaboration and training. Hence, our understanding of how the central nervous system communicates with end organs throughout the body is in its infancy. Neural Control of Organ Degeneration and Regeneration (NeuralCODR), a cross-disciplinary training program unites 30 faculty members and 12 clinician researchers to form mentorship teams within the largest medical research center in the world (Texas Medical Center). Mentorship teams include a primary and secondary mentor (each from one of our three main areas of research: 1) neural development and tools, 2) neural innervation and organ engineering, and 3) nervous system and peripheral organ disorders) and a clinical mentor who provides much needed and rare exposure to real-world diseases, clinical challenges, and human samples. NeuralCODR aims to: 1) catalyze the collision of talent and ideas that spawn research projects bridging neuroscience with organ systems through facilitated interactions, 2) build co-mentor teams that include neuroscience, organ systems, and clinical perspectives, ensuring trainees are guided toward a unique research niche, and 3) train fellows in research rigor, analysis, and career skills that support their development as scientific leaders. NeuralCODR leverages a network of faculty who collaborate on projects that bridge the gap between organ system biology and engineering and neural function, degeneration and regeneration, as evidenced by an impressive list of multi-laboratory shared grants, publications, and nascent collaborations. The training structure emphasizes experiences in organ engineering and organ physiology laboratories in parallel with education in neurophysiology and neural engineering, translational theory, and practice. Currently, two NeuralCODR Houston Methodist-specific postdoctoral positions exist, thanks to a philanthropic endowment that has allowed us to build the program structure and to test both the coursework and mentorship team concept. Trainees are funded for two years, during which time they have access to a core curriculum, career development and program enrichment opportunities, symposiums/retreats, and elective courses. Year one culminates with the submission of an NRSA and a manuscript based on trainees’ development of a transformative research project that incorporates non-neuroscience expertise and tools into a neuroscience problem. Year two solidifies the relationships between the mentorship team and trainee and provides training in laboratory management, didactic teaching, and mentorship skills. T32 funding will allow us to increase the current model to six postdoctoral training slots. This training program will foster a new generation of scientific leaders who pioneer research on the connected pathways between brain and organ systems to solve fundamental challenges in neuroscience.