Spinal Neuromodulation to Promote Physiologic and Molecular Plasticity in theInjured Spinal Cord
脊髓神经调节促进受损脊髓的生理和分子可塑性
基本信息
- 批准号:10805726
- 负责人:
- 金额:$ 46.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-20 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAnatomyAnimal ExperimentsAnimalsAreaBiologyCervicalCervical spinal cord injuryCervical spinal cord structureChronicClinicalClinical DataClinical ResearchContusionsDataDevicesDorsalDoseEffectivenessElectric StimulationElectrodesEngineeringFamilyFiberForelimbFutureGene ExpressionGenetic TranscriptionHourInformaticsInjuryInvestigationLesionLocomotionMapsMethodsModelingMolecularMotorMuscleNeuronal PlasticityParalysedPathway interactionsPatientsPatternPerformancePersonsPhysiologicalPhysiologyPositioning AttributePublishingQuadriplegiaQuality of lifeRattusRecoveryRecovery of FunctionRehabilitation therapyReportingResearchRetinal blind spotRodentRoleSensorySiteSpeedSpinalSpinal CordSpinal cord injuryStrokeSurfaceTestingTimeTrainingTraumatic Brain InjuryUpper ExtremityVertebral columnWalkingWorkcandidate identificationcentral pattern generatorclinically relevantcostexperienceexperimental studyfunctional improvementfunctional plasticitygene regulatory networkhand rehabilitationimprovedinnovationinsightinterestintraspinal microstimulationmotor recoverynerve injuryneuralneuroinflammationneuroregulationnovelnovel strategiespre-clinicalrestorationtranscriptomics
项目摘要
Abstract
There is growing interest in the use of electrical stimulation to promote the recovery of sensorimotor and
autonomic function after neural injury. Previous research from our lab and others has demonstrated that
stimulation of spinal lumbar segments activates central pattern generators, which, in turn, facilitates standing
and walking. However, while there is extensive animal, pre-clinical, and clinical data examining the impact of
lumbar stimulation, studies that apply neuromodulation to the cervical spinal cord for upper limb are very limited.
Here, we propose that fundamental blind spots exist in the field of neuromodulation for upper limb, including
where to stimulate anatomically, how to dose and, especially, mechanisms of action. The Horner lab has
developed a clinically relevant rat model of cervical spinal cord injury and engineered a self-contained epidural
stimulation device that can be deployed in freely behaving rats to stimulate sensorimotor circuitry from multiple
surfaces of the spinal cord. Hence, we are well positioned to test critically important hypotheses on the role of
cervical stimulation in the restoration of upper limb function. We present exciting preliminary data demonstrating
that epidural stimulation of the cervical spinal cord improves forelimb function. The rationale for the proposed
research is that the site of epidural stimulation provides unique access to motor circuitry. We hypothesize that
ventral positioning of electrodes (VSS) will provide access to stimulate motor circuitry at the site of
lesion that are inaccessible from the more common dorsal approach (DSS). Further, we propose that
VSS will produce novel mechanisms of function plasticity that can amplify recovery when combined with
DSS. To test this hypothesis, we propose the following aims: Aim 1: Determine acute molecular and physiological
mechanisms of VSS when applied to subacute cervical spinal cord injury. Aim 2: Establish the functional impact
of site of stimulation and rehabilitative training on recovery from early chronic cervical spinal cord injury. Aim 3:
Establish the synergistic effects of combined VSS and DSS after cervical spinal cord injury. These studies will
explore an exciting new approach to promote neural recovery of the upper limb, an area of research that has
had limited investigation, but remains a primary concern for the patient. Our approach will rigorously establish
the physiological and functional effects of the site of stimulation on the molecular and physiological mechanisms
of upper limb plasticity.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Philip J Horner其他文献
Philip J Horner的其他文献
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{{ truncateString('Philip J Horner', 18)}}的其他基金
Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)
器官退化和再生的神经控制培训(NeuralCODR)
- 批准号:
10620833 - 财政年份:2022
- 资助金额:
$ 46.94万 - 项目类别:
Patricia Levy Zusman International Workshop on Neuroregeneration (Zusman Workshop)
Patricia Levy Zusman 神经再生国际研讨会(Zusman 研讨会)
- 批准号:
10607404 - 财政年份:2022
- 资助金额:
$ 46.94万 - 项目类别:
Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)
器官退化和再生的神经控制培训(NeuralCODR)
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10410250 - 财政年份:2022
- 资助金额:
$ 46.94万 - 项目类别:
A versatile reporter for visualization of myelin plasticity in the genetically modified rat
一种多功能报告基因,用于可视化转基因大鼠的髓磷脂可塑性
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10303241 - 财政年份:2021
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CNS Neuroregeneration strategies: Discovery and Implementation
中枢神经系统神经再生策略:发现和实施
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9332048 - 财政年份:2017
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Astrocyte-specific ligand discovery by phage display
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Metabolic requirements of adult neural stem cells
成体神经干细胞的代谢需求
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8068094 - 财政年份:2011
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$ 46.94万 - 项目类别:
Metabolic requirements of adult neural stem cells
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8321500 - 财政年份:2011
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$ 46.94万 - 项目类别:
Combined stem cell transplantation and targeted microstimulation to direct the fo
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Ultrasound-aided gene transfer to direct cortical neurogenesis after brain injury
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8722168 - 财政年份:2009
- 资助金额:
$ 46.94万 - 项目类别:
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