UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery

摘要 迫切需要建立一支专注于阿尔茨海默病的神经退行性疾病专家队伍 随着疾病的发展，生物医学研究界对多学科科学家的需求不断增加。 尽管存在这一巨大需求，但提供学术和临床经验的培训项目却很少 设置。这项关于阿尔茨海默氏病和相关痴呆症药物发现培训计划的提案是 对于满足不断增长的需求至关重要。该项目的总体目标是资助五名博士生 来自药学院和医学院的学生成为跨学科研究的经验丰富的领导者 能够与具有广泛专业知识的跨学科团队进行有效协作，以应对内部挑战 基于靶点的药物发现。该计划将帮助选定的学生培养敏锐的科学严谨性和 在未来工作场所竞争和脱颖而出所需的转化技能，包括但不限于学术能力 机构、政府机构、营利性企业和私人基金会。重要的是，该计划 教师来自广泛的学科，并进行了许多积极的合作。十二位导师尽职尽责 参加该培训计划的人员均是终身职位或终身职位，拥有经验和资金 承担培训和指导的职责。这些教师将为学员提供独特的课程，其中 学习合作研究项目的技术和方法。拟议的培训计划是 由正式的教学课程、基于讨论的期刊俱乐部和研讨会、临床医生的跟踪和 指导研究得出博士论文和博士学位。进入研究生院后5.5年内获得学位。 这一创新计划将培养出一批具有高成就的学员，这些学员将在 进而促进我们为该大学的跨学科培训项目招募最优秀的学生 内布拉斯加州医疗中心。

Abstract With a critical need to establish a workforce of specialists in neurodegenerative diseases focusing on Alzheimer’s disease, there is an increasing demand for multidisciplinary scientists in the biomedical research community. Despite this significant need, there are few training programs that provide experience in academic and clinical settings. This proposal for an Alzheimer’s Disease and Related-Dementia Drug Discovery training program is critical to meeting that increased demand. The overall goal of this program is to fund five predoctoral students from the Colleges of Pharmacy and Medicine to become experienced leaders in interdisciplinary research with the ability to collaborate effectively on cross-disciplinary teams with broad expertise to address challenges within target-based drug discovery. The program will help the selected students to develop keen scientific rigor and translational skills necessary to compete and excel in the future workplace, including but not limited to academic institutions, government agencies, for-profit businesses, and private foundations. Importantly, the program faculty are drawn from a wide array of disciplines with many active collaborations. Twelve mentors are dedicated to this training program, all either tenured or in tenure track positions, with the experience and funding to undertake their training and mentoring roles. These faculty will provide trainees with a unique program in which to learn techniques and methodologies of collaborative research projects. The proposed training program is composed of formal didactic courses, discussion-based journal clubs and seminars, shadowing of a clinician and mentored research leading to a doctoral thesis and Ph.D. degree within 5.5 years of entering graduate school. This innovative program will produce an outstanding output of trainees with high accomplishments that will in turn catalyze our recruitment of the best students for this interdisciplinary training program at the University of Nebraska Medical Center.