UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery

UNMC 阿尔茨海默病和相关痴呆药物发现培训计划

• 批准号: 10411479
• 负责人: HOWARD S FOX
• 金额: $ 16.27万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411479
• 关键词: Alzheimer' s disease related dementia; Training Programs; drug discovery

Abstract With a critical need to establish a workforce of specialists in neurodegenerative diseases focusing on Alzheimer’s disease, there is an increasing demand for multidisciplinary scientists in the biomedical research community. Despite this significant need, there are few training programs that provide experience in academic and clinical settings. This proposal for an Alzheimer’s Disease and Related-Dementia Drug Discovery training program is critical to meeting that increased demand. The overall goal of this program is to fund five predoctoral students from the Colleges of Pharmacy and Medicine to become experienced leaders in interdisciplinary research with the ability to collaborate effectively on cross-disciplinary teams with broad expertise to address challenges within target-based drug discovery. The program will help the selected students to develop keen scientific rigor and translational skills necessary to compete and excel in the future workplace, including but not limited to academic institutions, government agencies, for-profit businesses, and private foundations. Importantly, the program faculty are drawn from a wide array of disciplines with many active collaborations. Twelve mentors are dedicated to this training program, all either tenured or in tenure track positions, with the experience and funding to undertake their training and mentoring roles. These faculty will provide trainees with a unique program in which to learn techniques and methodologies of collaborative research projects. The proposed training program is composed of formal didactic courses, discussion-based journal clubs and seminars, shadowing of a clinician and mentored research leading to a doctoral thesis and Ph.D. degree within 5.5 years of entering graduate school. This innovative program will produce an outstanding output of trainees with high accomplishments that will in turn catalyze our recruitment of the best students for this interdisciplinary training program at the University of Nebraska Medical Center.

摘要 迫切需要建立一支专注于阿尔茨海默氏症的神经退行性疾病专家队伍 疾病，有一个多学科的科学家在生物医学研究界的需求越来越大。 尽管这一重大需求，有几个培训计划，提供学术和临床经验， 设置.阿尔茨海默病和相关痴呆症药物发现培训计划的建议是 这对满足日益增长的需求至关重要。该计划的总体目标是资助五名博士前学生 从药学院和医学院成为经验丰富的跨学科研究的领导者， 能够在具有广泛专业知识的跨学科团队中进行有效合作，以应对内部挑战 靶向药物发现。该计划将帮助选定的学生发展敏锐的科学严谨性， 在未来的工作场所竞争和脱颖而出所需的翻译技能，包括但不限于学术 机构、政府机构、营利性企业和私人基金会。重要的是，该计划 教师来自广泛的学科，有许多积极的合作。十二位导师致力于 参加这个培训计划，所有人都是终身制或终身制职位，有经验和资金， 承担起培训和指导的角色。这些教师将为学员提供一个独特的计划，其中 学习合作研究项目的技术和方法。拟议的培训方案是 包括正式的教学课程，讨论为基础的期刊俱乐部和研讨会，临床医生的影子， 指导研究导致博士论文和博士学位。在进入研究生院的5.5年内获得学位。 这个创新的计划将产生一个优秀的输出与高成就的学员，将在 反过来催化我们的招聘最好的学生为这个跨学科的培训计划在大学 内布拉斯加医疗中心