NNTC Data Coordinating Center

NNTC数据协调中心

• 批准号: 10392844
• 负责人: HOWARD S FOX
• 金额: $ 97.53万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392844
• 关键词: AIDS/HIV problem; Address; Aging; Ancillary Study; Animal Model; Autopsy; Bioinformatics; Biometry; Blood; Brain; Cerebrospinal Fluid; Clinical; Clinical Research; Collaborations; Collection; Communication; Communities; Consequences of HIV; Data; Data Coordinating Center; Data Repository and Coordinating Center; Data Set; Databases; Diagnosis; Disease; Ensure; Epidemiology; Equipment and supply inventories; Funding; Goals; HIV; HIV Infections; HIV antiretroviral; HIV therapy; HIV-1; Human; Immunologics; In Vitro; Knowledge; Laboratories; Leadership; Learning; Libraries; Link; Liquid substance; Medical; Metadata; Modeling; National NeuroAids Tissue Consortium; Neurodegenerative Disorders; Neurologic; Organ; Outcome; Participant; Pathologic; Patients; Peer Review; Peripheral Nervous System; Privacy; Public Relations; Publications; Quality Control; Recording of previous events; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Research Subjects; Resources; Role; Services; Source; Specimen; Structure; Testing; Time; Tissues; United States National Institutes of Health; Viral; Work; antiretroviral therapy; brain tissue; central database; clinical database; clinical research site; cohort; comorbidity; data acquisition; data archive; data repository; data sharing; design; experimental study; follow-up; human disease; innovation; knowledge base; meetings; neuroAIDS; operation; prevent; query tools; recruit; research study; web site

Project Summary/Abstract The Data Coordinating Center (DCC) supports the National NeuroAIDS Tissue Consortium (NNTC). The consortium is composed of four NNTC Clinical Sites and the DCC that work cooperatively as a resource for the research community, providing HIV/AIDS investigators with clinically annotated datasets of antemortem information and associated postmortem tissue and fluids. The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations; (2) scientific expertise in biostatistics and HIV epidemiology to support broad analyses of the NNTC clinical database and analyses that support the recruitment and retention goals for the cohort; and (3) identify gaps and provide solutions to neuroAIDS investigators. The DCC serves as the point of contact for users of the resource (tissue and/or data requests) and services the requests from the time they are submitted through fulfillment of the request and follow up with the requestor to provide the results of their research. The DCC expanded to include the CHARTER study bringing in longitudinal participants and ancillary studies. In this next funding period, the Global CERCH will be developed to enable collaborations and the sharing of specimens and data relating to CSF escape, expanding the DCC's ability to support ongoing neuroAIDS research. The DCC websites are used extensively for dissemination of resource information (query tools, reports, request applications) and management tasks such as resource tracking, document libraries, and communication activities. The DCC provides a central inventory of NNTC data and specimens. Along with this inventory, additional research data such as bioinformatics datasets by the users of the resource are available. The DCC promotes the NNTC through public relations materials including a comprehensive website and meeting presentations. In the past funding period, the NNTC supported 356 separate research grants and 157 peer- reviewed publications.

项目总结/摘要 数据协调中心（DCC）支持国家神经艾滋病组织联盟（NNTC）。的 联盟由四个NNTC临床研究中心和DCC组成，它们作为资源合作， 研究社区，为艾滋病毒/艾滋病调查人员提供临床注释的死前数据集， 信息和相关的死后组织和液体。DCC与NNTC临床合作 研究中心应提供（1）管理和数据库功能，以确保有效的临床和脑库 （2）生物统计学和艾滋病毒流行病学方面的科学专门知识，以支持国家核技术委员会的广泛分析 支持队列招募和保留目标的临床数据库和分析;以及（3）识别 并为神经艾滋病研究人员提供解决方案。发展协调委员会是 资源（组织和/或数据请求），并从请求提交之时起， 满足请求，并与请求者跟进，以提供他们的研究结果。的DCC 扩大到包括CHARTER研究，引入纵向参与者和辅助研究。在下一 在资助期间，将开发全球CERCH，以实现合作和共享标本 以及与CSF逃逸相关的数据，扩大了DCC支持正在进行的神经艾滋病研究的能力。的 发展协调委员会网站广泛用于传播资源信息（查询工具、报告、请求 应用程序）和管理任务，如资源跟踪、文档库和通信 活动DCC提供了NNTC数据和标本的中央库存。沿着这份清单， 另外的研究数据，例如资源用户的生物信息学数据集也是可用的。的DCC 通过公共关系材料，包括综合网站和会议，宣传国家核技术委员会 介绍。在过去的资助期内，NNTC支持了356项独立的研究赠款和157项同行研究资助。 审查出版物。

项目成果

The 3-Item "Apathy" Subscale Within the GDS-15 Is Not Supported in De Novo Parkinson's Disease Patients: Analysis of the PPMI Cohort.

• DOI: 10.1177/0891988720988908
• 发表时间: 2022-05
• 期刊: JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
• 影响因子: 2.6
• 作者: Szymkowicz, Sarah M.;Ellis, Liam J.;May, Pamela E.
• 通讯作者: May, Pamela E.

The HIV Restriction Factor Profile in the Brain Is Associated with the Clinical Status and Viral Quantities.

• DOI: 10.3390/v15020316
• 发表时间: 2023-01-23
• 期刊: Viruses
• 作者: Mohammadzadeh N;Zhang N;Branton WG;Zghidi-Abouzid O;Cohen EA;Gelman BB;Estaquier J;Kong L;Power C
• 通讯作者: Power C

Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individuals.

• DOI: 10.1038/s41598-021-88052-7
• 发表时间: 2021-06-09
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Sanna PP;Fu Y;Masliah E;Lefebvre C;Repunte-Canonigo V
• 通讯作者: Repunte-Canonigo V

CSF Inflammation Markers Associated with Asymptomatic Viral Escape in Cerebrospinal Fluid of HIV-Positive Individuals on Antiretroviral Therapy.

• DOI: 10.3390/v15091829
• 发表时间: 2023-08-29
• 期刊: Viruses
• 作者: Guha D;Misra V;Yin J;Gabuzda D
• 通讯作者: Gabuzda D

Epigenetic clock and methylation studies in the rhesus macaque.

• DOI: 10.1007/s11357-021-00429-8
• 发表时间: 2021-10
• 期刊: GeroScience
• 影响因子: 5.6
• 作者: Horvath S;Zoller JA;Haghani A;Jasinska AJ;Raj K;Breeze CE;Ernst J;Vaughan KL;Mattison JA
• 通讯作者: Mattison JA