NNTC Data Coordinating Center

NNTC数据协调中心

• 批准号: 9403730
• 负责人: HOWARD S FOX
• 金额: $ 104.88万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2018-03-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9403730
• 关键词: AIDS/HIV problem; Address; Aging; Animal Model; Autopsy; Bioinformatics; Biometry; Blood; Book Chapters; Brain; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical Research; Clinical assessments; Collaborations; Communication; Communities; Consequences of HIV; Data; Data Coordinating Center; Data Set; Data Sources; Databases; Diagnosis; Disease; Ensure; Epidemiology; Equipment and supply inventories; Fostering; Foxes; Goals; Grant; HIV; HIV Infections; HIV therapy; HIV-associated neurocognitive disorder; Highly Active Antiretroviral Therapy; Human; Immunologics; In Vitro; Information Systems; Instruction; Knowledge; Laboratories; Leadership; Learning; Libraries; Link; Liquid substance; Medical; Metadata; Modeling; National NeuroAids Tissue Consortium; Neurodegenerative Disorders; Neurologic; Organ; Outcome; Pathogenicity; Pathologic; Patients; Peer Review; Peripheral Nervous System; Privacy; Public Relations; Publications; Quality Control; Recording of previous events; Recruitment Activity; Reporting; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Services; Specimen; Structure; System; Testing; Time; Tissues; United States National Institutes of Health; Voting; Work; brain tissue; clinical research site; cohort; data acquisition; data archive; data sharing; design; experimental study; follow-up; human disease; improved; innovation; knowledge base; meetings; member; neuroAIDS; operation; tool; virology; web site

DESCRIPTION (provided by applicant): The project supports the Data Coordinating Center (DCC) to the National NeuroAIDS Tissue Consortium (NNTC). The NNTC is a resource for investigators conducting NeuroAIDS research to identify the neuropathogenic mechanisms involved In HIV disease of the central and peripheral nervous systems. The consortium is composed of four NNTC Clinical Sites and one DCC that work cooperatively as a resource for the research community, providing HIV/AIDS Investigators with clinically annotated datasets of antemortem Information and associated postmortem tissue and fluids. The DCC provides the NNTC with scientific leadership, management expertise, bioinformatics and Information systems infrastructure, statistical and epidemiology expertise, and serves as a voting member of the NNTC Steering Committee. The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations and (2) scientific expertise in biostatistics and HIV epidemiology to support broad analyses of the NNTC clinical database and analyses that support the recruitment and retention goals for the cohort. The NNTC has produced over 380 peer-reviewed publications, over 175 abstracts/book chapters/presentations, as well as supporting the work on numerous researchers' grants. The DCC serves as the point of contact for users of the resource (tissue and/or data requests) and services the requests from the time they are submitted through fulfillment of the request and follow up with the requestor to provide the results of their researc. The NNTC website is used extensively for dissemination of resource Information (query tools, reports, request applications) and management tasks such as resource tracking, document libraries, and communication activities. An inventory of all specimens housed at each NNTC Clinical Site will be maintained, as will be databases generated with additional research data beyond clinical assessments such as bioinformatics datasets by the users of the resource. The DCC promotes the NNTC through public relations materials including a comprehensive website and meeting presentations. RELEVANCE (See instructions): The NNTC has served as a valuable resource to the NeuroAIDS research community since 1998. Its continuation is critical given the need for quality CNS tissues and related antemortem clinical data. Investigators using these resources examine emerging research topics in the NeuroAIDS field such as: a) eradication of HIV from persistent CNS reservoirs; b) pathogenic mechanisms of HIV-associated neurocognitive disorders (HAND) in setting of long term HAART; and c) HIV and aging.

描述(由申请人提供)：该项目支持数据协调中心(DCC)到国家神经艾滋病组织联盟(NNTC)。NNTC是为进行神经艾滋病研究的研究人员提供的资源，以确定涉及中枢和外周神经系统艾滋病毒疾病的神经致病机制。该联盟由四个NNTC临床站点和一个DCC组成，它们作为研究社区的资源进行合作，为艾滋病毒/艾滋病研究人员提供带有临床注释的生前信息数据集和相关的死后组织和液体。DCC为NNTC提供科学领导、管理专业知识、生物信息学和信息系统基础设施、统计和流行病学专业知识，并是NNTC指导委员会的投票成员。DCC与NNTC临床网站合作，提供(1)管理和数据库能力，以确保有效的临床和脑银行运营，(2)生物统计学和艾滋病毒流行病学方面的科学专业知识，以支持对NNTC临床数据库的广泛分析，以及支持队列招募和保留目标的分析。NNTC已经出版了380多份同行评议的出版物，175多篇摘要/书籍章节/演示文稿，并支持了许多研究人员的补助金工作。DCC充当资源(组织和/或数据请求)的用户的联系点，并从提交请求到完成请求并与请求者跟进以提供他们的研究结果开始服务。NNTC网站广泛用于传播资源信息(查询工具、报告、请求应用程序)和管理任务，如资源跟踪、文档库和通信活动。将维护每个NNTC临床站点保存的所有标本的库存，以及使用临床评估以外的其他研究数据生成的数据库，如资源用户的生物信息学数据集。DCC通过公关材料宣传NNTC，包括一个全面的网站和会议介绍。相关性(见说明)：自1998年以来，NNTC一直是神经艾滋病研究界的宝贵资源。考虑到对高质量的中枢神经系统组织和相关的生前临床数据的需求，它的继续是至关重要的。使用这些资源的研究人员审查了神经艾滋病领域的新研究主题，例如：a)从持久的中枢神经系统储存库中根除艾滋病毒；b)在长期HAART的背景下艾滋病毒相关神经认知障碍(HAND)的致病机制；以及c)艾滋病毒与老龄化。