NNTC Data Coordinating Center

NNTC数据协调中心

• 批准号: 8670030
• 负责人: HOWARD S FOX
• 金额: $ 85.31万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8670030
• 关键词: AIDS neuropathy; AIDS/HIV problem; Address; Aging; Animal Model; Archives; Autopsy; Bioinformatics; Biometry; Blood; Book Chapters; Brain; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical Research; Clinical assessments; Collaborations; Communication; Communities; Confidentiality; Consequences of HIV; Data; Data Base Management; Data Coordinating Center; Data Set; Data Sources; Databases; Diagnosis; Disease; Ensure; Epidemiology; Equipment and supply inventories; Fostering; Foxes; Goals; Grant; HIV; HIV Infections; HIV therapy; Highly Active Antiretroviral Therapy; Housing; Human; Immunologics; In Vitro; Information Systems; Instruction; Knowledge; Knowledge Discovery; Laboratories; Leadership; Learning; Libraries; Link; Liquid substance; Medical; Metadata; Modeling; Neurocognitive; Neurodegenerative Disorders; Neurologic; Organ; Outcome; Patients; Peer Review; Peripheral Nervous System; Privacy; Public Relations; Publications; Quality Control; Recording of previous events; Reporting; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Services; Specimen; Structure; System; Testing; Time; Tissues; United States National Institutes of Health; Voting; Work; abstracting; brain tissue; clinical research site; cohort; data acquisition; data sharing; design; follow-up; human disease; improved; innovation; knowledge base; meetings; member; operation; research study; tissue resource; tool; web site

DESCRIPTION (provided by applicant): The project supports the Data Coordinating Center (DCC) to the National NeuroAIDS Tissue Consortium (NNTC). The NNTC is a resource for investigators conducting NeuroAIDS research to identify the neuropathogenic mechanisms involved In HIV disease of the central and peripheral nervous systems. The consortium is composed of four NNTC Clinical Sites and one DCC that work cooperatively as a resource for the research community, providing HIV/AIDS Investigators with clinically annotated datasets of antemortem Information and associated postmortem tissue and fluids. The DCC provides the NNTC with scientific leadership, management expertise, bioinformatics and Information systems infrastructure, statistical and epidemiology expertise, and serves as a voting member of the NNTC Steering Committee. The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations and (2) scientific expertise in biostatistics and HIV epidemiology to support broad analyses of the NNTC clinical database and analyses that support the recruitment and retention goals for the cohort. The NNTC has produced over 380 peer-reviewed publications, over 175 abstracts/book chapters/presentations, as well as supporting the work on numerous researchers' grants. The DCC serves as the point of contact for users of the resource (tissue and/or data requests) and services the requests from the time they are submitted through fulfillment of the request and follow up with the requestor to provide the results of their researc. The NNTC website is used extensively for dissemination of resource Information (query tools, reports, request applications) and management tasks such as resource tracking, document libraries, and communication activities. An inventory of all specimens housed at each NNTC Clinical Site will be maintained, as will be databases generated with additional research data beyond clinical assessments such as bioinformatics datasets by the users of the resource. The DCC promotes the NNTC through public relations materials including a comprehensive website and meeting presentations. RELEVANCE (See instructions): The NNTC has served as a valuable resource to the NeuroAIDS research community since 1998. Its continuation is critical given the need for quality CNS tissues and related antemortem clinical data. Investigators using these resources examine emerging research topics in the NeuroAIDS field such as: a) eradication of HIV from persistent CNS reservoirs; b) pathogenic mechanisms of HIV-associated neurocognitive disorders (HAND) in setting of long term HAART; and c) HIV and aging.

描述（由申请人提供）：该项目支持国家神经艾滋病组织联盟（NNTC）的数据协调中心（DCC）。 NNTC 是研究人员进行 NeuroAIDS 研究的资源，旨在确定中枢和周围神经系统 HIV 疾病中涉及的神经病理机制。该联盟由四个 NNTC 临床中心和一个 DCC 组成，它们作为研究界的资源进行合作，为 HIV/艾滋病研究人员提供生前信息和相关死后组织和液体的临床注释数据集。 DCC 为 NNTC 提供科学领导、管理专业知识、生物信息学和信息系统基础设施、统计和流行病学专业知识，并作为 NNTC 指导委员会的投票成员。 DCC 与 NNTC 临床中心合作，提供 (1) 管理和数据库功能，以确保有效的临床和脑库操作，以及 (2) 生物统计学和 HIV 流行病学方面的科学专业知识，以支持对 NNTC 临床数据库的广泛分析以及支持队列招募和保留目标的分析。 NNTC 已出版了 380 多篇经过同行评审的出版物、超过 175 篇摘要/书籍章节/演示文稿，并为众多研究人员的资助工作提供支持。 DCC 充当资源（组织和/或数据请求）用户的联络点，从提交请求到满足请求，并跟踪请求者以提供其研究结果，为请求提供服务。 NNTC网站广泛用于传播资源信息（查询工具、报告、请求应用程序）和管理任务，例如资源跟踪、文档库和交流活动。每个 NNTC 临床站点保存的所有标本的清单都将得到维护，数据库也将由临床评估之外的其他研究数据（例如资源用户的生物信息学数据集）生成。 DCC 通过公共关系材料（包括综合网站和会议演示文稿）宣传 NNTC。相关性（参见说明）：自 1998 年以来，NNTC 一直是 NeuroAIDS 研究界的宝贵资源。考虑到对优质 CNS 组织和相关生前临床数据的需求，其持续发展至关重要。研究人员利用这些资源来研究神经艾滋病领域的新兴研究主题，例如：a）从持久性中枢神经系统病毒库中根除艾滋病毒； b) 长期HAART治疗中HIV相关神经认知障碍（HAND）的致病机制； c) 艾滋病毒与老龄化。