Core C. Biostatistics Core

摘要 生物统计核心负责向所有项目提供统计支助。核心将领导或协助 参与所有研究数据库的开发，并将领导其统计分析。核心将执行一项大型 各种建模任务，从使用相对风险(COX)模型或超额的生存分析 相对风险模型。核心将提供DNA甲基化数据的分析，包括质量控制、数据 标准化、软件选择和结果分析，并执行表观基因组范围的关联研究 戒烟时间和患肺癌的风险。核心将协助开发CYP2A6遗传评分和 在应用该评分方法分析肺癌病例对照资料中。核心还将提供 种族和吸烟差异分析，针对定向和非定向内收手术数据，最具统计学意义 分析将使用现有的R或SAS程序执行。在某些情况下，新的统计方法 如果现有的统计程序不足以进行分析，则可以开发。

ABSTRACT The Biostatistics Core is responsible for providing statistical support to all projects. The Core will lead or assist in the development of all study databases and will lead their statistical analysis. The Core will perform a large variety of modeling tasks ranging from survival analyses using either relative risk (Cox) models or excess relative risk models. The Core will provide analysis of DNA methylation data including quality control, data normalization, software selection, and outcome analysis, and perform epigenome-wide association studies of quitting duration, and lung cancer risk. The Core will assist in the development of a CYP2A6 genetic score and in the application of this score to the analysis of lung cancer case control data. The Core will also provide analysis of ethnic and smoking differences, for targeted and untargeted adductomics data, Most statistical analysis will be performed using existing R or SAS procedures. In some cases, new statistical methodology may be developed if existing statistical procedures are inadequate for analysis.