Research Training Program in Pediatric Exposomics

儿科暴露组学研究培训计划

• 批准号: 10410747
• 负责人: KECIA Nicole CARROLL
• 金额: $ 43.31万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410747
• 关键词: Childhood; Research Training; Training Programs

Project Summary The Developmental Origins of Health and Disease (DOHaD) theory posits that early-life environment contributes to nearly all common pediatric diseases (asthma, learning disorders, birth defects, obesity) and to diseases in adult life. Recently the nascent field of “exposomics” -the study of all health relevant environment across the lifespan has also taken hold, with new research initiatives such as the NIH Environmental influences on Child Health Outcomes (ECHO) program and the Human Health Exposure Analysis Resource (HHEAR) program. Multiple IOM reports state that there is a national need to expand research to address environmental medicine issues, and new NIH initiatives (HHEAR and ECHO) have emphasized that children's environmental health is a research priority. There is a clear need for scientists trained in the principles and methodologies of exposomics who can then translate research into environmental pediatrics. To address that need, the Mount Sinai School of Medicine seeks both to renew its 2-3 year transdisciplinary, post-doctoral research training program in environmental pediatrics that began in 2007 and to expand its scope to Exposomics, the study of all health relevant environment. Two fellows are admitted per year. Focus is on training in epidemiology, biostatistics, data science, lab assays, geospatial statistics, environmental medicine and of course, child health and development. An MS or MPH degree in epidemiology is available as well. Our program excels in mentored research that produces publications, meeting presentations/posters, NIH K awards and fosters transition toward independent research. Our fellows develop a methodological base in child development and exposure science principles giving them a versatile set of skills and resources that they can apply to study a wide range of scientific questions. Each fellow is guided by an interdisciplinary mentoring team. Courses and experiential training are provided in grant writing, ethics and responsible conduct of research. Supervised clinical experience in environmental pediatrics ensures that research training is grounded in clinical translational principles. Formal evaluation of fellows is conducted semi-annually. An Executive Faculty Committee and an External Advisory Board are in place. Our program builds on a unique base of NIH funded children's environmental health research, including 2 HHEAR Lab Hubs, the HHEAR Data Center, 2 ECHO cohorts, a P30 Core Center grant, multiple child health research cohorts, a Pediatric Environmental Health Specialty Unit, and a unique Exposome Lab that specializes in exposure biomarkers. In its first 14 years, our program has successfully recruited 30 fellows and graduated 24 (6 are still in training) of whom 14 have academic faculty positions; 2 are doing additional research training fellowships, and the remaining 8 are in industry or government. Seven have secured NIH funding; 4 in the last 5 years. Graduates are faculty at UC-Davis, Columbia, NYU, U Minnesota, U of Cincinnati, Mount Sinai, work at the CDC and for Industry, have published >400 papers and are now leaders in the nascent field of pediatric exposomics.

项目摘要 健康和疾病的发展起源（DOHaD）理论认为，早期生活环境 导致几乎所有常见的儿科疾病（哮喘、学习障碍、出生缺陷、肥胖）， 成人生活中的疾病最近新兴的领域“健康组学”-研究所有健康相关的环境 随着美国国立卫生研究院环境影响等新的研究计划的实施， 儿童健康结果（ECHO）计划和人类健康暴露分析资源（HHEAR） 程序.国际移民组织的多份报告指出，国家需要扩大研究， 医学问题，和新的NIH倡议（HHEAR和ECHO）强调，儿童的环境 健康是研究的优先事项。显然需要在科学的原则和方法方面受过训练的科学家， 他们可以将研究成果转化为环境儿科学。为了满足这一需求， 西奈医学院寻求更新其2-3年的跨学科，博士后研究培训 2007年开始的环境儿科学计划，并将其范围扩大到Exposomics，即对所有 健康相关的环境。每年招收两名研究员。重点是流行病学培训， 生物统计学、数据科学、实验室分析、地理空间统计、环境医学，当然还有儿童健康 发展先行者的要求流行病学的MS或MPH学位也可获得。我们的项目在指导方面表现出色 研究产生出版物，会议演示文稿/海报，NIH K奖和促进过渡 走向独立研究。我们的研究员在儿童发展和接触方面建立了方法论基础 科学原理为他们提供了一套多功能的技能和资源，他们可以应用于研究广泛的 科学问题。每个研究员都由一个跨学科的指导团队指导。课程和体验 提供赠款撰写、道德操守和负责任的研究行为方面的培训。监督的临床 环境儿科学的经验确保研究培训以临床转化为基础， 原则每半年对研究员进行一次正式评价。执行学院委员会和 外部咨询委员会已经到位。我们的项目建立在NIH资助的儿童项目的独特基础上。 环境健康研究，包括2个HHEAR实验室中心，HHEAR数据中心，2个ECHO队列， P30核心中心补助金，多个儿童健康研究队列，儿科环境健康专业单位， 和一个独特的暴露体实验室，专门研究暴露生物标志物。在最初的14年里，我们的计划 成功招募了30名研究员，24名研究员毕业（6名仍在培训中），其中14名具有学术能力 职位; 2人正在做额外的研究培训奖学金，其余8人在工业或 政府的7个获得了NIH的资助; 4个在过去5年中。毕业生是加州大学戴维斯分校的教师， 哥伦比亚大学、纽约大学、明尼苏达大学、辛辛那提大学、西奈山大学、疾病预防控制中心和工业部的工作人员都发表了 超过400篇论文，现在是儿科疾病组学新兴领域的领导者。