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Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma

以患者为导向的小儿哮喘研究中职业生涯研究者奖

基本信息

批准号：
10512564
负责人：
KECIA Nicole CARROLL
金额：
$ 11.17万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10512564
关键词：
Academic Medical Centers Address Adult Age Anti-Inflammatory Agents Antioxidants Asthma Award Body mass index Breast Feeding Child Child Health Childhood Childhood Asthma Chronic Classification Clinical Clinical Data Clinical Investigator Clinical Research Data Data Sources Development Diabetes Mellitus Disease Disease Outcome Effectiveness Electronic Health Record Environment Epidemiologist Exposure to Faculty Fellowship Fetus Fostering Funding Future Gestational Age Growth Immune system Immunologics Infant Inflammatory Investigation K-Series Research Career Programs Lead Life Link Lung Mentors Metabolic Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Mothers National Institute of Allergy and Infectious Disease Nutritional Outcome Oxidative Stress Pediatrics Play Policies Pregnancy Prevention Prospective Studies Prospective cohort Publications Pulmonology Research Research Design Research Personnel Risk Risk Factors Role Site Time Training Universities Wheezing asthma prevention career cohort comorbidity cost efficient experience gestational weight gain high risk immune health in utero interest lung health maternal diabetes mid-career faculty novel offspring patient oriented patient oriented research pediatrician prenatal prenatal exposure prenatal risk factor prepregnancy prepregnancy obesity programs prospective pulmonary function recruit respiratory health response secondary analysis skills smoking during pregnancy translational study traumatic stress

项目摘要

The candidate is currently an Associate Professor of Pediatrics at Vanderbilt University and a clinical investigator and epidemiologist whose research investigations are thematically linked through their focus on delineating prenatal and early life determinants of asthma and lung function to inform efforts to increase protective exposures, decrease adverse exposures, and inform prevention efforts. Prenatal exposures, such as diabetes during pregnancy, have the potential to have lifelong effects on respiratory health through associated systemic inflammatory, immunologic, or oxidative stress changes that influence the developing pulmonary or immune system of the fetus. The candidate’s current patient-oriented research investigations include prenatal exposures such as maternal traumatic stress, antioxidant and anti-inflammatory nutritional exposures, and oxidative stress, and she proposes to expand to investigations of diabetes during pregnancy and child asthma and lung function in prospective and novel cohorts of mother-child dyads. The candidate has developed a plan to increase and strengthen her skills in both patient-oriented research and mentoring to include formal research mentor training. The candidate proposes a mentoring plan for trainees to facilitate their effective transition from junior clinical investigator to independent investigators.

候选人目前是范德比尔特大学儿科副教授，其研究调查通过其重点在主题上联系在一起的调查员和流行病学家描述哮喘和肺功能的产前和早期决定因素，保护性暴露，减少不利暴露，并为预防工作提供信息。产前暴露，例如如妊娠期糖尿病，有可能对呼吸系统健康产生终身影响，相关的全身性炎症、免疫或氧化应激变化，这些变化影响了胎儿的肺或免疫系统。候选人目前以患者为导向的研究调查包括产前暴露，如母亲创伤性压力、抗氧化剂和抗炎营养暴露和氧化应激，她建议扩大到怀孕期间糖尿病的调查和儿童哮喘和肺功能的前瞻性和新的队列的母亲-儿童二对。这位候选人有制定了一项计划，以增加和加强她在以病人为导向的研究和指导方面的技能，包括正式研究指导员培训。候选人为学员提出指导计划，以促进他们的从初级临床研究者到独立研究者的有效过渡。