Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma

候选人目前是范德比尔特大学儿科副教授， 其研究调查通过其重点在主题上联系在一起的调查员和流行病学家 描述哮喘和肺功能的产前和早期决定因素， 保护性暴露，减少不利暴露，并为预防工作提供信息。产前暴露，例如 如妊娠期糖尿病，有可能对呼吸系统健康产生终身影响， 相关的全身性炎症、免疫或氧化应激变化，这些变化影响了 胎儿的肺或免疫系统。候选人目前以患者为导向的研究调查 包括产前暴露，如母亲创伤性压力、抗氧化剂和抗炎营养 暴露和氧化应激，她建议扩大到怀孕期间糖尿病的调查 和儿童哮喘和肺功能的前瞻性和新的队列的母亲-儿童二对。这位候选人有 制定了一项计划，以增加和加强她在以病人为导向的研究和指导方面的技能， 包括正式研究指导员培训。候选人为学员提出指导计划，以促进他们的 从初级临床研究者到独立研究者的有效过渡。

The candidate is currently an Associate Professor of Pediatrics at Vanderbilt University and a clinical investigator and epidemiologist whose research investigations are thematically linked through their focus on delineating prenatal and early life determinants of asthma and lung function to inform efforts to increase protective exposures, decrease adverse exposures, and inform prevention efforts. Prenatal exposures, such as diabetes during pregnancy, have the potential to have lifelong effects on respiratory health through associated systemic inflammatory, immunologic, or oxidative stress changes that influence the developing pulmonary or immune system of the fetus. The candidate’s current patient-oriented research investigations include prenatal exposures such as maternal traumatic stress, antioxidant and anti-inflammatory nutritional exposures, and oxidative stress, and she proposes to expand to investigations of diabetes during pregnancy and child asthma and lung function in prospective and novel cohorts of mother-child dyads. The candidate has developed a plan to increase and strengthen her skills in both patient-oriented research and mentoring to include formal research mentor training. The candidate proposes a mentoring plan for trainees to facilitate their effective transition from junior clinical investigator to independent investigators.