Research Training Program in Pediatric Exposomics

项目摘要 健康与疾病的发展起源(DOHAD)理论认为，早期生命环境 导致几乎所有常见的儿科疾病(哮喘、学习障碍、出生缺陷、肥胖)和 成人生活中的疾病。近年来，“暴露组学”的新兴领域--所有与健康相关的环境研究 随着NIH环境影响等新的研究倡议的实施，跨越寿命的研究也得到了支持 关于儿童健康结果(ECHO)计划和人类健康暴露分析资源(HHEAR) 程序。国际移民组织的多份报告指出，国家需要扩大研究，以解决环境问题 医学问题和新的NIH倡议(HHEAR和ECHO)强调，儿童的环境 健康是研究的优先事项。显然，科学家需要受过训练的原则和方法论 暴露组学，然后可以将研究转化为环境儿科学。为了满足这一需求，摩托 西奈医学院寻求更新其2-3年跨学科博士后研究培训 2007年开始的环境儿科学计划，并将其范围扩大到暴露组学，即对所有人的研究 健康相关的环境。每年招收两名研究员。重点是流行病学方面的培训， 生物统计学、数据科学、实验室分析、地理空间统计学、环境医学，当然还有儿童健康 和发展。还可以获得流行病学硕士或公共卫生硕士学位。我们的计划在指导方面表现出色 制作出版物、会议演示文稿/海报、NIH K奖项和促进过渡的研究 走向独立研究。我们的研究员在儿童发展和接触方面建立了方法论基础 科学原理为他们提供了一套多才多艺的技能和资源，他们可以应用于广泛的学习 科学问题。每个研究员都由一个跨学科的指导团队指导。课程和体验式 提供赠款撰写、道德规范和负责任的研究行为方面的培训。督导临床 环境儿科的经验确保研究培训以临床翻译为基础 原则。对研究员的正式评价每半年进行一次。行政学院委员会和一个 外部咨询委员会已经就位。我们的项目建立在美国国立卫生研究院资助的儿童 环境健康研究，包括2个HHEAR实验室中心、HHEAR数据中心、2个ECHO队列、1 P30核心中心赠款，多个儿童健康研究队列，一个儿科环境健康专科单位， 和一个专门研究暴露生物标记物的独特的Exposome实验室。在最初的14年里，我们的计划已经 成功招聘了30名研究员，24名毕业生(6名仍在培训中)，其中14名为学术人员 职位；2个正在做额外的研究培训奖学金，其余8个在工业或 政府。7个已经获得了NIH的资助；4个在过去的5年里。毕业生是加州大学戴维斯分校的教员， 哥伦比亚大学，纽约大学，明尼苏达大学，辛辛那提大学，西奈山大学，在疾控中心工作和工业，已经发表了 &gt；400篇论文，现在是新生的儿科暴露组学领域的领导者。

Project Summary The Developmental Origins of Health and Disease (DOHaD) theory posits that early-life environment contributes to nearly all common pediatric diseases (asthma, learning disorders, birth defects, obesity) and to diseases in adult life. Recently the nascent field of “exposomics” -the study of all health relevant environment across the lifespan has also taken hold, with new research initiatives such as the NIH Environmental influences on Child Health Outcomes (ECHO) program and the Human Health Exposure Analysis Resource (HHEAR) program. Multiple IOM reports state that there is a national need to expand research to address environmental medicine issues, and new NIH initiatives (HHEAR and ECHO) have emphasized that children's environmental health is a research priority. There is a clear need for scientists trained in the principles and methodologies of exposomics who can then translate research into environmental pediatrics. To address that need, the Mount Sinai School of Medicine seeks both to renew its 2-3 year transdisciplinary, post-doctoral research training program in environmental pediatrics that began in 2007 and to expand its scope to Exposomics, the study of all health relevant environment. Two fellows are admitted per year. Focus is on training in epidemiology, biostatistics, data science, lab assays, geospatial statistics, environmental medicine and of course, child health and development. An MS or MPH degree in epidemiology is available as well. Our program excels in mentored research that produces publications, meeting presentations/posters, NIH K awards and fosters transition toward independent research. Our fellows develop a methodological base in child development and exposure science principles giving them a versatile set of skills and resources that they can apply to study a wide range of scientific questions. Each fellow is guided by an interdisciplinary mentoring team. Courses and experiential training are provided in grant writing, ethics and responsible conduct of research. Supervised clinical experience in environmental pediatrics ensures that research training is grounded in clinical translational principles. Formal evaluation of fellows is conducted semi-annually. An Executive Faculty Committee and an External Advisory Board are in place. Our program builds on a unique base of NIH funded children's environmental health research, including 2 HHEAR Lab Hubs, the HHEAR Data Center, 2 ECHO cohorts, a P30 Core Center grant, multiple child health research cohorts, a Pediatric Environmental Health Specialty Unit, and a unique Exposome Lab that specializes in exposure biomarkers. In its first 14 years, our program has successfully recruited 30 fellows and graduated 24 (6 are still in training) of whom 14 have academic faculty positions; 2 are doing additional research training fellowships, and the remaining 8 are in industry or government. Seven have secured NIH funding; 4 in the last 5 years. Graduates are faculty at UC-Davis, Columbia, NYU, U Minnesota, U of Cincinnati, Mount Sinai, work at the CDC and for Industry, have published >400 papers and are now leaders in the nascent field of pediatric exposomics.