Research Training Program in Pediatric Exposomics

儿科暴露组学研究培训计划

• 批准号: 10678633
• 负责人: KECIA Nicole CARROLL
• 金额: $ 44.93万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678633
• 关键词: Childhood; Research Training; Training Programs

Project Summary The Developmental Origins of Health and Disease (DOHaD) theory posits that early-life environment contributes to nearly all common pediatric diseases (asthma, learning disorders, birth defects, obesity) and to diseases in adult life. Recently the nascent field of “exposomics” -the study of all health relevant environment across the lifespan has also taken hold, with new research initiatives such as the NIH Environmental influences on Child Health Outcomes (ECHO) program and the Human Health Exposure Analysis Resource (HHEAR) program. Multiple IOM reports state that there is a national need to expand research to address environmental medicine issues, and new NIH initiatives (HHEAR and ECHO) have emphasized that children's environmental health is a research priority. There is a clear need for scientists trained in the principles and methodologies of exposomics who can then translate research into environmental pediatrics. To address that need, the Mount Sinai School of Medicine seeks both to renew its 2-3 year transdisciplinary, post-doctoral research training program in environmental pediatrics that began in 2007 and to expand its scope to Exposomics, the study of all health relevant environment. Two fellows are admitted per year. Focus is on training in epidemiology, biostatistics, data science, lab assays, geospatial statistics, environmental medicine and of course, child health and development. An MS or MPH degree in epidemiology is available as well. Our program excels in mentored research that produces publications, meeting presentations/posters, NIH K awards and fosters transition toward independent research. Our fellows develop a methodological base in child development and exposure science principles giving them a versatile set of skills and resources that they can apply to study a wide range of scientific questions. Each fellow is guided by an interdisciplinary mentoring team. Courses and experiential training are provided in grant writing, ethics and responsible conduct of research. Supervised clinical experience in environmental pediatrics ensures that research training is grounded in clinical translational principles. Formal evaluation of fellows is conducted semi-annually. An Executive Faculty Committee and an External Advisory Board are in place. Our program builds on a unique base of NIH funded children's environmental health research, including 2 HHEAR Lab Hubs, the HHEAR Data Center, 2 ECHO cohorts, a P30 Core Center grant, multiple child health research cohorts, a Pediatric Environmental Health Specialty Unit, and a unique Exposome Lab that specializes in exposure biomarkers. In its first 14 years, our program has successfully recruited 30 fellows and graduated 24 (6 are still in training) of whom 14 have academic faculty positions; 2 are doing additional research training fellowships, and the remaining 8 are in industry or government. Seven have secured NIH funding; 4 in the last 5 years. Graduates are faculty at UC-Davis, Columbia, NYU, U Minnesota, U of Cincinnati, Mount Sinai, work at the CDC and for Industry, have published >400 papers and are now leaders in the nascent field of pediatric exposomics.

项目总结

项目成果

Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring.

• DOI: 10.1097/ypg.0b013e328351850b
• 发表时间: 2012-06
• 期刊: Psychiatric genetics
• 影响因子: 0.9
• 作者: Miodovnik A;Diplas AI;Chen J;Zhu C;Engel SM;Wolff MS
• 通讯作者: Wolff MS

Modeling of regional climate change effects on ground-level ozone and childhood asthma.

区域气候变化对地面臭氧和儿童哮喘的影响。

• DOI: 10.1016/j.amepre.2011.04.017
• 发表时间: 2011-09
• 期刊: AMERICAN JOURNAL OF PREVENTIVE MEDICINE
• 影响因子: 5.5
• 作者: Sheffield, Perry E.;Knowlton, Kim;Carr, Jessie L.;Kinney, Patrick L.
• 通讯作者: Kinney, Patrick L.

Piloting a Developmental Screening Tool Adapted for East African Children.

• DOI: 10.3390/children5080101
• 发表时间: 2018-07-26
• 期刊: Children (Basel, Switzerland)
• 作者: Sajady MA;Mehus CJ;Moody EC;Jaramillo EG;Mupere E;Barnes AJ;Cusick SE
• 通讯作者: Cusick SE

Prenatal phthalate exposure is associated with childhood behavior and executive functioning.

• DOI: 10.1289/ehp.0901470
• 发表时间: 2010-04
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Engel SM;Miodovnik A;Canfield RL;Zhu C;Silva MJ;Calafat AM;Wolff MS
• 通讯作者: Wolff MS

Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development.

探索早期发展研究中的空气污染、邻里剥夺和自闭症谱系障碍。

• DOI: 10.1097/ee9.0000000000000067
• 发表时间: 2019
• 期刊: Environmental epidemiology (Philadelphia, Pa.)
• 作者: McGuinn,LauraA;Windham,GayleC;Messer,LynneC;Di,Qian;Schwartz,Joel;Croen,LisaA;Moody,EricJ;Rappold,AnaG;Richardson,DavidB;Neas,LucasM;Gammon,MarilieD;Schieve,LauraA;Daniels,JulieL
• 通讯作者: Daniels,JulieL