Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease Outcomes

怀孕叶酸状况

基本信息

  • 批准号:
    8164104
  • 负责人:
  • 金额:
    $ 74.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-06 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Research Area. The long-term goal of this project is to determine whether maternal folic acid supplementation during pregnancy increases the risk of early childhood asthma and atopy. Supplementation with folic acid, synthetic folate, is recommended during the periconceptional period to prevent neural tube defects (NTD). Studies in different populations have suggested an association between reported folic acid supplementation during pregnancy and increased risk of infant lower respiratory tract infection and early childhood asthma, but data are limited. While adequate intake of folate is essential for prevention of NTDs, it is important to delineate the impact of supplementation on the risk of common respiratory and atopic diseases. Folate plays an important role in DNA methylation, a regulator of gene expression. A causal relationship between folic acid supplementation and respiratory outcomes in children has not been established. However, this relationship does have some biologic plausibility. In a pregnant mouse model, a diet high in methyl donors, including folate, resulted in an augmented allergic phenotype in the offspring, as seen in asthma. Opportunity and Impact. There is no primary prevention strategy for atopic diseases such as asthma. Our objective is to determine whether higher maternal folate intake or the timing of this intake increases the risk of wheezing, asthma, and other atopic diseases in children. This collective work will characterize maternal folate status using objective measures and will assess childhood wheezing, asthma, allergic rhinitis, and atopic dermatitis using validated tools and objective measures. This will be the first investigation in a country with a national fortification program, where individuals may have high intake of folic acid from the diet. Approach. This work will use complementary retrospective and prospective cohorts of mother-child pairs. Specific aim #1 will investigate the population-based incidence of wheezing and asthma during the first 6 years of life, by the timing of folic acid containing prescriptions filled during pregnancy in a retrospective cohort of 80,000 mother-child dyads from the Tennessee Medicaid population. Specific Aim #2 will determine if a) measured maternal plasma folate levels or b) reported folate intake is associated with prospective development of wheezing, asthma, and/or atopy in the first 5 years of life in mother-child dyads enrolled in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) cohort. Innovation and Sustainability. This innovative, cost-efficient project will have the advantages of 1) a well-characterized retrospective cohort with a large number of mother-child dyads and determination of folic acid prescriptions filled by month of pregnancy and 2) a prospective cohort that includes the rich, existing infrastructure of the CANDLE cohort with maternal and infant biospecimens, nutritional data, and prospective follow-up using validated tools and objective measures to assess respiratory and atopic outcomes. This study has potential to inform prenatal recommendations and identify modifiable risk factors for asthma and atopy.
描述(由申请人提供):研究领域。该项目的长期目标是确定母亲在怀孕期间补充叶酸是否会增加儿童早期哮喘和特应性的风险。补充叶酸,合成叶酸,建议在围受孕期,以防止神经管缺陷(NTD)。在不同人群中进行的研究表明,报告的怀孕期间补充叶酸与婴儿下呼吸道感染和幼儿哮喘风险增加之间存在关联,但数据有限。虽然足够的叶酸摄入对于预防NTD至关重要,但重要的是要描述补充剂对常见呼吸道和特应性疾病风险的影响。叶酸在DNA甲基化中起重要作用,DNA甲基化是基因表达的调节剂。叶酸补充剂和儿童呼吸结果之间的因果关系尚未确定。然而,这种关系确实具有一定的生物相容性。在一个怀孕的小鼠模型中,高甲基供体(包括叶酸)的饮食导致后代的过敏表型增加,如哮喘中所见。 机会和影响。对于哮喘等特应性疾病没有初级预防策略。我们的目的是确定母亲叶酸摄入量较高或摄入时间是否会增加儿童喘息、哮喘和其他特应性疾病的风险。这项集体工作将使用客观的措施来表征母亲的叶酸水平,并使用有效的工具和客观的措施来评估儿童喘息、哮喘、过敏性鼻炎和特应性皮炎。这将是在一个有国家强化计划的国家进行的第一次调查,在这个国家,个人可能从饮食中摄入大量叶酸。 Approach.这项工作将使用互补的回顾性和前瞻性的母子配对队列。具体目标#1将在田纳西州医疗补助人群中的80,000对母子回顾性队列中,通过妊娠期间服用含叶酸处方的时间,调查出生后前6年内基于人群的喘息和哮喘发病率。具体目标#2将确定a)测量的母体血浆叶酸水平或B)报告的叶酸摄入量是否与入组影响儿童早期神经认知发育和学习的疾病(CANDLE)队列的母子二人组在出生后前5年内预期发生喘息、哮喘和/或特应性相关。 创新和可持续性。这个创新的、具有成本效益的项目将具有以下优点:1)一个具有大量母婴配对和确定按妊娠月份填写的叶酸处方的良好特征的回顾性队列; 2)一个前瞻性队列,包括CANDLE队列的丰富的现有基础设施,包括孕产妇和婴儿生物标本、营养数据、和前瞻性随访,使用有效的工具和客观的措施,以评估呼吸和特应性的结果。这项研究有可能为产前建议提供信息,并确定哮喘和特应性的可改变的危险因素。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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KECIA Nicole CARROLL其他文献

KECIA Nicole CARROLL的其他文献

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{{ truncateString('KECIA Nicole CARROLL', 18)}}的其他基金

Associations among maternal lifetime psychosocial stress, prenatal systemic and placental oxidative stress mixtures, and child asthma
母亲一生心理社会压力、产前全身和胎盘氧化应激混合物与儿童哮喘之间的关联
  • 批准号:
    10660716
  • 财政年份:
    2023
  • 资助金额:
    $ 74.23万
  • 项目类别:
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung Function
母亲创伤应激、氧化应激、抗氧化剂暴露以及儿童哮喘和肺功能
  • 批准号:
    10469874
  • 财政年份:
    2021
  • 资助金额:
    $ 74.23万
  • 项目类别:
Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma
以患者为导向的小儿哮喘研究中职业生涯研究者奖
  • 批准号:
    10512564
  • 财政年份:
    2019
  • 资助金额:
    $ 74.23万
  • 项目类别:
Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma
以患者为导向的小儿哮喘研究中职业生涯研究者奖
  • 批准号:
    10533384
  • 财政年份:
    2019
  • 资助金额:
    $ 74.23万
  • 项目类别:
Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma
以患者为导向的小儿哮喘研究中职业生涯研究者奖
  • 批准号:
    10064017
  • 财政年份:
    2019
  • 资助金额:
    $ 74.23万
  • 项目类别:
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung Function
母亲创伤应激、氧化应激、抗氧化剂暴露以及儿童哮喘和肺功能
  • 批准号:
    9263527
  • 财政年份:
    2017
  • 资助金额:
    $ 74.23万
  • 项目类别:
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung Function
母亲创伤应激、氧化应激、抗氧化剂暴露以及儿童哮喘和肺功能
  • 批准号:
    10094068
  • 财政年份:
    2017
  • 资助金额:
    $ 74.23万
  • 项目类别:
Mount Sinai ECHO site for Perinatal Environment and Development Studies
西奈山 ECHO 围产期环境和发展研究网站
  • 批准号:
    10745103
  • 财政年份:
    2016
  • 资助金额:
    $ 74.23万
  • 项目类别:
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease Outcomes
怀孕叶酸状况
  • 批准号:
    8494691
  • 财政年份:
    2011
  • 资助金额:
    $ 74.23万
  • 项目类别:
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease Outcomes
怀孕叶酸状况
  • 批准号:
    8298154
  • 财政年份:
    2011
  • 资助金额:
    $ 74.23万
  • 项目类别:

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