UCSD Alzheimer's Disease Research Centers P30

总体-总结/摘要 阿尔茨海默病和相关痴呆症（ADRD）共同构成了一个重要的和不断增长的公众 造成巨大代价和深重的痛苦。除非疾病可以 有效地治疗或预防，随着人口统计学的变化，患病率的增加将导致成本的增加， 国家将难以承受。为了反映这一全国性的当务之急，《国家阿尔茨海默病项目法》 （NAPA）制定了到2025年影响这种疾病的路线图和目标。目前关于延长供资的提议 UCSD Shiley-Marcos阿尔茨海默病研究中心（ADRC）明确与NAPA保持一致， 利用该中心在过去35年中建立的深厚根基和参与。该中心丰富的学术 和社区环境，使其能够与ADC网络协同工作， 国家适应行动方案的目标和里程碑，特别是沿着通过 在不同志愿者队列中研究模型、标记物和机制。具体而言，该中心建议 这项工作将把世界一流的先进转化神经科学带到异质性研究中， 使用新的模式和新的、量身定制的社区参与方法来实现ADRD的多样性。包括 通过其新的iPSC核心培养的创新疾病模型，并增加了与拉丁美洲人的接触 美洲印第安人社区通过建立一个拉丁美洲核心。努力与职能紧密结合 在该中心长期以来获得的巨大资源和经验的支持下， 存在，同时结合最具创新性，破坏性和尖端科学上的多， UCSD校园该中心将实现以下总体目标，统一其基础广泛的活动 在研究，教育，参与，分享和协同与ADC网络：该中心将1） 应用完善的和互动的核心，以促进跨学科，综合和创新的临床和 转化科学，2）教育和培训多样化的劳动力，3）为科学和社区提供一个中心 交流和支持，优化核心工作和协同作用，以最好地为当地和更广泛的患者服务， 护理人员和研究社区，4）参与跨中心的合作研究，特别是 强调应用中心的优势，以补充ADC网络并扩大其影响。

OVERALL – SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) together constitute a paramount and growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increased prevalence with changing demographics will lead to costs the country will find difficult to bear. Reflecting this national imperative, the National Alzheimer’s Project Act (NAPA) created a roadmap and goal to impact this disease by 2025. The current proposal for renewed funding of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) explicitly aligns with NAPA and leverages the center’s deep roots and engagement built over the past 35 years. The center’s rich academic and community environment make it well positioned to synergize with the ADC network toward achievement of NAPA goals and milestones, particularly along the theme of examining heterogeneity of ADRD through the study of models, markers, and mechanisms in a diverse cohort of volunteers. Specifically, the center proposes work that will bring world-class advanced translational neurosciences to the study of heterogeneity and diversity in ADRD using new models and new, tailored community engagement approaches. including innovative disease in a dish models fostered by its new iPSC Core, and increased engagement with the Latino Amerindian community through the establishment of a Latino Core. Efforts are tightly integrated with functions of other cores bolstered by tremendous resources and experience gained over the center’s longstanding existence, while incorporating the most innovative, disruptive and cutting-edge science available on the multi- faceted UCSD campus. The center will achieve the following overarching aims unifying its broad-based activity in research, education, engagement, and sharing and synergizing with the ADC network: The center will 1) apply well-developed and interactive cores to foster cross-disciplinary, integrative, and innovative clinical and translational science, 2) educate and train a diverse workforce, 3) Provide a hub for scientific and community exchange and support, optimizing core efforts and synergies to best serve the local and broader patient, caregiver, and research communities and 4) engage in collaborative research across centers, with special emphasis on applying center strengths to complement the ADC network and extend its impact.