UCSD Alzheimer's Disease Research Centers P30

总体--摘要/摘要 阿尔茨海默病和相关痴呆症(ADRD)共同构成了最重要的和日益增长的公众 健康问题，具有巨大的成本和深不可测的总痛苦。除非这些疾病可以 有效的治疗或预防，随着人口结构的变化而增加的流行率将导致 这个国家将很难承受。反映这一国家迫切需要的是，国家阿尔茨海默氏症项目法 (NAPA)制定了到2025年影响这一疾病的路线图和目标。目前关于续签资金的提议 加州大学圣迭戈分校Shiley-Marcos阿尔茨海默病研究中心(ADRC)的成员明确表示与NAPA和 利用该中心在过去35年中建立的深厚根基和参与度。该中心丰富的学术知识 和社区环境使其处于有利地位，与ADC网络协同工作，以实现 国家适应行动方案的目标和里程碑，特别是沿着通过 在不同的志愿者队列中研究模型、标志物和机制。具体来说，该中心建议 这项工作将把世界级先进的翻译神经科学引入异质性和 利用新的模式和新的、量身定制的社区参与方法，促进可持续发展的多样性。包括 由其新的iPSC Core培育的菜肴模型中的创新疾病，以及与拉丁裔更多的接触 美洲印第安人社区通过建立一个拉丁裔核心。努力与职能紧密结合 其他核心得到了该中心长期积累的巨大资源和经验的支持 存在，同时融合了最具创新性、颠覆性和尖端的科学 加州大学圣迭戈分校的校园。该中心将实现以下总体目标，统一其广泛的活动 在研究、教育、参与以及与ADC网络的共享和协同方面：该中心将1) 应用成熟和互动的核心，促进跨学科、集成和创新的临床和 翻译科学，2)教育和培训多样化的劳动力，3)提供科学和社区的枢纽 交流和支持，优化核心努力和协同效应，最好地为当地和更广泛的患者服务， 护理者、研究社区和4)参与跨中心的协作研究，特别是 强调应用中心优势来补充ADC网络并扩大其影响。

OVERALL – SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) together constitute a paramount and growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increased prevalence with changing demographics will lead to costs the country will find difficult to bear. Reflecting this national imperative, the National Alzheimer’s Project Act (NAPA) created a roadmap and goal to impact this disease by 2025. The current proposal for renewed funding of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) explicitly aligns with NAPA and leverages the center’s deep roots and engagement built over the past 35 years. The center’s rich academic and community environment make it well positioned to synergize with the ADC network toward achievement of NAPA goals and milestones, particularly along the theme of examining heterogeneity of ADRD through the study of models, markers, and mechanisms in a diverse cohort of volunteers. Specifically, the center proposes work that will bring world-class advanced translational neurosciences to the study of heterogeneity and diversity in ADRD using new models and new, tailored community engagement approaches. including innovative disease in a dish models fostered by its new iPSC Core, and increased engagement with the Latino Amerindian community through the establishment of a Latino Core. Efforts are tightly integrated with functions of other cores bolstered by tremendous resources and experience gained over the center’s longstanding existence, while incorporating the most innovative, disruptive and cutting-edge science available on the multi- faceted UCSD campus. The center will achieve the following overarching aims unifying its broad-based activity in research, education, engagement, and sharing and synergizing with the ADC network: The center will 1) apply well-developed and interactive cores to foster cross-disciplinary, integrative, and innovative clinical and translational science, 2) educate and train a diverse workforce, 3) Provide a hub for scientific and community exchange and support, optimizing core efforts and synergies to best serve the local and broader patient, caregiver, and research communities and 4) engage in collaborative research across centers, with special emphasis on applying center strengths to complement the ADC network and extend its impact.