UCSD Alzheimer's Disease Research Centers P30

加州大学圣地亚哥分校阿尔茨海默病研究中心 P30

• 批准号: 10766603
• 负责人: JAMES B BREWER
• 金额: $ 30.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10766603
• 关键词: Achievement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapy; Amerindian; Caregivers; Clinical Sciences; Communities; Complement; Country; Creativeness; Development; Disease; Diverse Workforce; Education; Environment; Fostering; Funding; Goals; Heterogeneity; Latino; Medical; Modeling; Patients; Population Heterogeneity; Positioning Attribute; Prevalence; Public Health; Research; Research Personnel; Resources; Science; Study models; Training; Translational Research; Work; cohort; community engagement; cost; demographics; disease-in-a-dish; experience; induced pluripotent stem cell; innovation; next generation; prevent; scientific hub; success; synergism; translational neuroscience; volunteer

Abstract Alzheimer's disease and related dementias (ADRD) together constitute a paramount and growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increased prevalence with changing demographics will lead to costs the country will find difficult to bear. Reflecting this national imperative, the National Alzheimer's Project Act (NAPA) created a roadmap and goal to impact this disease by 2025. The current proposal for renewed funding of the UCSD Shiley-Marcos Alzheimer's Disease Research Center (ADRC) explicitly aligns with NAPA and leverages the center's deep roots and engagement built over the past 35 years. The center's rich academic and community environment make it well positioned to synergize with the ADC network toward achievement of NAPA goals and milestones, particularly along the theme of examining heterogeneity of ADRD through the study of models, markers, and mechanisms in a diverse cohort of volunteers. Specifically, the center proposes work that will bring world-class advanced translational neurosciences to the study of heterogeneity and diversity in ADRD using new models and new, tailored community engagement approaches. Including innovative disease in a dish models fostered by its new iPSC Core, and increased engagement with the Latino Amerindian community through the establishment of a Latino Core. Efforts are tightly integrated with functions of other cores bolstered by tremendous resources and experience gained over the center's longstanding existence, while incorporating the most innovative, disruptive and cutting-edge science available on the multifaceted UCSD campus. The center will achieve the following overarching aims unifying its broad-based activity in research, education, engagement, and sharing and synergizing with the ADC network: The center will 1) apply well-developed and interactive cores to foster cross-disciplinary, integrative, and innovative clinical and translational science, 2) educate and train a diverse workforce, 3) Provide a hub for scientific and community exchange and support, optimizing core efforts and synergies to best serve the local and broader patient, caregiver, and research communities and 4) engage in collaborative research across centers, with special emphasis on applying center strengths to complement the ADC network and extend its impact.

摘要 阿尔茨海默病和相关痴呆症（ADRD）共同构成了一个重要的和不断增长的公共卫生 这些问题带来了巨大代价和难以估量的痛苦。除非这些疾病能够有效地 无论是治疗还是预防，随着人口结构的变化，患病率的增加将导致该国付出代价 难以忍受。为了反映这一全国性的迫切需要，《国家阿尔茨海默病项目法》（NAPA）制定了一个 到2025年影响这一疾病的路线图和目标。目前对加州大学圣地亚哥分校重新拨款的建议 Shiley-Marcos阿尔茨海默病研究中心（ADRC）明确与NAPA保持一致，并利用 中心在过去35年中建立的深厚根基和参与。该中心丰富的学术和社区 环境使其能够与发展援助委员会网络协同努力，实现国家适应行动方案的目标 和里程碑，特别是沿着通过模型研究检查ADRD异质性的主题， 标记物和机制。具体而言，该中心提出的工作将 将世界一流的先进转化神经科学引入ADRD异质性和多样性的研究 使用新的模式和新的、量身定制的社区参与方法。包括创新疾病， 通过新的iPSC核心培养的碟形模型，并增加与拉丁美洲印第安人社区的接触 通过建立一个拉丁美洲核心。努力与其他核心的功能紧密结合， 通过该中心长期存在所获得的巨大资源和经验， 最具创新性，破坏性和尖端的科学在多方面的UCSD校园可用。的 中心将实现以下总体目标，统一其在研究，教育， 参与，与ADC网络共享和协同：该中心将1）应用开发良好， 互动核心，以促进跨学科，综合和创新的临床和转化科学，2） 教育和培训多样化的劳动力，3）提供科学和社区交流和支持的中心， 优化核心工作和协同作用，以最好地服务于当地和更广泛的患者，护理人员和研究 社区和4）参与跨中心的合作研究，特别强调应用中心 这是一个重要的优势，以补充ADC网络并扩大其影响。

项目成果

Lay Caregivers' Experiences With Caring for Persons With Dementia: A Phenomenological Study.

• DOI: 10.3928/00989134-20200527-02
• 发表时间: 2020-08-01
• 期刊: Journal of gerontological nursing
• 影响因子: 1.3
• 作者: Mayo AM;Siegle K;Savell E;Bullock B;Preston GJ;Peavy GM
• 通讯作者: Peavy GM

Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.

• DOI: 10.1021/acsomega.1c00660
• 发表时间: 2021-05-25
• 期刊: ACS omega
• 影响因子: 4.1
• 作者: Podvin S;Jones A;Liu Q;Aulston B;Mosier C;Ames J;Winston C;Lietz CB;Jiang Z;O'Donoghue AJ;Ikezu T;Rissman RA;Yuan SH;Hook V
• 通讯作者: Hook V

Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta.

• DOI: 10.1093/braincomms/fcac272
• 发表时间: 2022
• 期刊: BRAIN COMMUNICATIONS
• 影响因子: 4.8
• 作者: Weigand, Alexandra J.;Edwards, Lauren E.;Thomas, Kelsey R.;Bangen, Katherine J.;Bondi, Mark W.
• 通讯作者: Bondi, Mark W.

Active immunization in Alzheimer's disease.

阿尔茨海默病的主动免疫。

• DOI: 10.1038/s43587-021-00076-w
• 发表时间: 2021
• 期刊: Nature aging
• 作者: Galasko,Douglas

NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression.

• DOI: 10.3390/cells10123514
• 发表时间: 2021-12-13
• 期刊: Cells
• 影响因子: 6
• 作者: Mengel D;Mok TH;Nihat A;Liu W;Rissman RA;Galasko D;Zetterberg H;Mead S;Collinge J;Walsh DM
• 通讯作者: Walsh DM