UCSD Alzheimer's Disease Research Centers P30

加州大学圣地亚哥分校阿尔茨海默病研究中心 P30

• 批准号: 10615159
• 负责人: JAMES B BREWER
• 金额: $ 305.08万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10615159
• 关键词: Achievement; Address; Adherence; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapy; Amerindian; Area; Autopsy; Awareness; Biological Markers; Brain; Caregivers; Chronic; Clinical; Clinical Sciences; Clinical Trials; Cognition; Cognitive; Collaborations; Communities; Complement; Country; County; Creativeness; Data; Data Science; Development; Diagnosis; Disease; Diverse Workforce; Education; Environment; Fostering; Functional disorder; Funding; Genetic; Goals; Heterogeneity; Image; Informatics; Knowledge; Latino; Latino Population; Leadership; Medical; Medical Research; Methodology; Methods; Minority; Modeling; Molecular; Observation in research; Onset of illness; Participant; Pathologic; Pathway interactions; Patients; Phenotype; Population Heterogeneity; Positioning Attribute; Prevalence; Psychophysiology; Public Health; Recording of previous events; Research; Research Personnel; Resources; Risk; Science; Scientist; Series; Specimen; Staging; Study models; Training; Translational Research; Underrepresented Minority; Underrepresented Populations; Work; clinical heterogeneity; cohort; community based participatory research; community engagement; cost; demographics; disease-in-a-dish; experience; genetic variant; induced pluripotent stem cell; innovation; interest; meetings; next generation; novel strategies; prevent; programs; recruitment science; research study; responsible research conduct; retention rate; scientific hub; statistics; stem cell model; success; symposium; synergism; translational neuroscience; volunteer

OVERALL – SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) together constitute a paramount and growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increased prevalence with changing demographics will lead to costs the country will find difficult to bear. Reflecting this national imperative, the National Alzheimer’s Project Act (NAPA) created a roadmap and goal to impact this disease by 2025. The current proposal for renewed funding of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) explicitly aligns with NAPA and leverages the center’s deep roots and engagement built over the past 35 years. The center’s rich academic and community environment make it well positioned to synergize with the ADC network toward achievement of NAPA goals and milestones, particularly along the theme of examining heterogeneity of ADRD through the study of models, markers, and mechanisms in a diverse cohort of volunteers. Specifically, the center proposes work that will bring world-class advanced translational neurosciences to the study of heterogeneity and diversity in ADRD using new models and new, tailored community engagement approaches. including innovative disease in a dish models fostered by its new iPSC Core, and increased engagement with the Latino Amerindian community through the establishment of a Latino Core. Efforts are tightly integrated with functions of other cores bolstered by tremendous resources and experience gained over the center’s longstanding existence, while incorporating the most innovative, disruptive and cutting-edge science available on the multi- faceted UCSD campus. The center will achieve the following overarching aims unifying its broad-based activity in research, education, engagement, and sharing and synergizing with the ADC network: The center will 1) apply well-developed and interactive cores to foster cross-disciplinary, integrative, and innovative clinical and translational science, 2) educate and train a diverse workforce, 3) Provide a hub for scientific and community exchange and support, optimizing core efforts and synergies to best serve the local and broader patient, caregiver, and research communities and 4) engage in collaborative research across centers, with special emphasis on applying center strengths to complement the ADC network and extend its impact.

总体——总结/摘要 阿尔茨海默氏病和相关痴呆症 (ADRD) 共同构成了一个重要且不断增长的公众疾病 造成巨大代价和难以估量的总体痛苦的健康问题。除非疾病可以 有效治疗或预防，随着人口结构的变化而增加患病率将导致成本 国家将难以承受。 《国家阿尔茨海默病项目法案》反映了这一国家当务之急 (NAPA) 制定了到 2025 年影响这种疾病的路线图和目标。当前的更新资金提案 加州大学圣地亚哥分校希利-马科斯阿尔茨海默病研究中心 (ADRC) 的研究明确与 NAPA 保持一致， 利用该中心过去 35 年建立的深厚根基和参与度。中心学术资源丰富 和社区环境使其能够与 ADC 网络发挥协同作用，以实现 NAPA 目标和里程碑，特别是通过审查 ADRD 异质性的主题 对不同志愿者群体的模型、标记和机制进行研究。具体来说，中心提出 这项工作将把世界一流的先进转化神经科学带入异质性和 使用新模型和新的、定制的社区参与方法来实现 ADRD 的多样性。包括 其新的 iPSC 核心培育出创新的培养皿模型疾病，并增加了与拉丁裔的接触 美洲印第安人社区通过建立拉丁裔核心。努力与职能紧密结合 其他核心得到了该中心长期积累的巨大资源和经验的支持 存在，同时融合了多领域中最具创新性、颠覆性和尖端的科学 多面的加州大学圣地亚哥分校校园。该中心将通过统一其广泛的活动来实现以下总体目标 在研究、教育、参与以及与 ADC 网络共享和协同方面：该中心将 1) 应用成熟和互动的核心来培养跨学科、综合性和创新性的临床和 转化科学，2) 教育和培训多元化的劳动力，3) 提供科学和社区中心 交流和支持，优化核心努力和协同作用，以最好地服务当地和更广泛的患者， 护理人员和研究团体，4) 参与跨中心的合作研究，特别是 强调运用中心优势来补充 ADC 网络并扩大其影响力。