Personality prediction of dementia risk and progression

该项目将评估人格和其他非认知风险因素(如情感、恢复力)对阿尔茨海默病(AD)和AD相关痴呆的模式和进展以及身体和认知障碍的变化的影响和缓和作用。在阿尔茨海默病、AD相关痴呆、一般认知障碍和身体健康状况的个体变化的背景下，个人个性、他们的情感和韧性的影响是需要考虑的关键因素。我们接受精确医学的概念，在理解个体差异因素的意义上，这些因素是健康变化(包括阿尔茨海默病和AD相关痴呆症)风险和弹性的基础。 风险因素的个体差异是该项目的核心。这一多项研究项目的一个重要方面是有可能重点解释阿尔茨海默病、AD相关痴呆以及身体和认知障碍的独立研究结果的差异。。我们发现，在以前的协调分析中，使用相同的人格测量并使用相同的模型进行分析的研究之间的效果大小往往存在很大的差异，因此我们提出了系统的元回归分析来更好地评估这些个体和研究水平的差异。这一方法有望更深入地了解与阿尔茨海默病和AD相关痴呆相关的生活方式因素，以及一般认知障碍和身体健康。影响：该项目涉及NIA的研究目标，支持检查心理和社会因素之间的相互作用及其在阿尔茨海默病和AD相关痴呆中的作用，以及更普遍的认知障碍和身体健康下降。它还通过我们的多研究协调分析格式的本质，促进了健壮性、可复制性和再现性，特别是在阿尔茨海默病和AD相关痴呆症研究的背景下。

This project will evaluate the role of personality and other non-cognitive risk factors (e.g., affect, resilience) that impact and moderate the pattern and progression of Alzheimer’s disease (AD) and AD-related dementia, as well as change in physical and cognitive impairment. The impact of an individual’s personality, their affect, and resilience are critical factors to take into account in the context of individual changes in onset and progression of Alzheimer’s disease, AD-related dementia, general cognitive impairment, and physical health status. We embrace the concept of precision medicine, in the sense of understanding individual differences factors that underlie risk and resilience to health changes, including Alzheimer’s disease and AD-related dementia. Individual differences in risk factors are at the heart of this project. An important aspect of this multi-study project is the potential to focus on explanations for variation in findings across independent studies of Alzheimer’s disease, AD-related dementia, and physical and cognitive impairment. . We have found that in previous coordinated analyses there is often wide variation in effect sizes across studies that utilize identical measures of personality and have been analyzed using identical models, hence we propose systematic meta-regression analyses to evaluate better these individual and study-level differences. This approach promises a more in- depth understanding of lifestyle factors related to Alzheimer’s disease and AD-related dementia, as well as general cognitive impairment and physical health. Impact: This project addresses NIA research goals supporting the examination of the interplay between psychological and social factors and their role in Alzheimer’s disease and AD-related dementia, as well as more general cognitive impairment and physical health declines. It also promotes robustness, replicability and reproducibility, particularly in the context of Alzheimer’s disease and AD-related dementia research, through the very nature of our multi-study coordinated analysis format.