Training OPportunites in Translational Imaging Education and Research (TOP-TIER)

转化成像教育和研究的培训机会（顶级）

• 批准号: 10411698
• 负责人: Hongyu An
• 金额: $ 26.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411698
• 关键词: Image; Training; education research

PROJECT SUMMARY TOP-TIER (Training OPportunities in Translational Imaging Education and Research) is a clinician scientist post-doctoral training program at Washington University (WU) in St. Louis designed with the purpose of providing trainees with instruction in the performance of rigorous translational imaging research. The goal is to prepare resident and fellow trainees for careers as successful independent investigators and to ultimately become leaders in their field, developing imaging techniques and applications that translate into human subjects and impact healthcare. Precision Medicine is an approach to disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Development of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be needed to advance Precision Medicine. Moreover, a trained workforce is key to taking advantage of new developments in machine learning and artificial intelligence which can be applied across disciplines, to include targeted molecular imaging, photoacoustics, and magnetic resonance imaging (MRI) in terms of data acquisition, image processing, and diagnosis. Such imaging advances are interdisciplinary with technology innovations crossing the physical, biological, and data sciences. These studies start with preclinical mechanistic inquiries using targeted pathology-based imaging in animal disease models, and then expand into human subjects. Human studies include safety testing and the Food and Drug Administration’s (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate goal is to make research innovations widely available to the public and the entire practicing medical community. Although this “bench-to-bedside” process has been widely acclaimed, there remains a knowledge gap in the medical imaging research community as to how to take preclinical research into humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and fellows – often lack the understanding to navigate research regulatory requirements as well as the knowledge base to understand or perform preclinical research that will inform the mechanism of innovation. In this T32 renewal, we have optimized training to provide supportive Mentoring Teams and cover technical advances, research rigor, and the practical aspects of grant submission to better prepare future imaging scientists for the challenges of performing science which impacts healthcare.

项目概要 TOP-TIER（转化成像教育和研究培训机会）是一名临床科学家 圣路易斯华盛顿大学 (WU) 的博士后培训项目旨在 为学员提供进行严格的转化成像研究的指导。目标 是为住院医师和实习生做好成为成功的独立调查员的职业准备，并 最终成为各自领域的领导者，开发成像技术和应用程序，转化为 人类受试者并影响医疗保健。精准医学是一种疾病治疗和治疗的方法 考虑到基因、环境和生活方式的个体差异的预防。发展 用于指导和监测患者特异性治疗的患者特异性生物标志物成像方法将是 推进精准医学所需。此外，训练有素的劳动力对于利用新的技术至关重要。 机器学习和人工智能的发展可以跨学科应用 包括靶向分子成像、光声学和磁共振成像 (MRI) 数据采集​​、图像处理和诊断。这种成像技术的进步是跨学科的 跨越物理、生物和数据科学的技术创新。这些研究始于 在动物疾病模型中使用基于病理学的靶向成像进行临床前机制调查，以及 然后扩展到人类受试者。人体研究包括安全测试以及食品和药物 主管部门 (FDA) 的研究性新药 (IND) 和器械豁免 (IDE) 流程。终极 目标是让公众和整个医学实践领域广泛获得研究创新 社区。尽管这种“从实验室到临床”的过程受到了广泛好评，但仍然存在 医学影像研究界在如何将临床前研究纳入临床前研究方面存在知识差距 人类，以及如何将这些创新推向公众。此外，临床科学家——居民和 研究员——往往缺乏理解研究监管要求以及 用于理解或进行临床前研究的知识库，这些研究将为创新机制提供信息。 在本次 T32 更新中，我们优化了培训，以提供支持性指导团队并涵盖技术 进步、研究严谨性以及拨款申请的实际方面，以更好地为未来的成像做好准备 科学家们应对影响医疗保健的科学研究挑战。