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Training OPportunites in Translational Imaging Education and Research (TOP-TIER)

转化成像教育和研究的培训机会（顶级）

基本信息

批准号：
10671722
负责人：
Hongyu An
金额：
$ 23.43万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-07 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10671722
关键词：
Education Research Training image translation

项目摘要

PROJECT SUMMARY TOP-TIER (Training OPportunities in Translational Imaging Education and Research) is a clinician scientist post-doctoral training program at Washington University (WU) in St. Louis designed with the purpose of providing trainees with instruction in the performance of rigorous translational imaging research. The goal is to prepare resident and fellow trainees for careers as successful independent investigators and to ultimately become leaders in their field, developing imaging techniques and applications that translate into human subjects and impact healthcare. Precision Medicine is an approach to disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Development of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be needed to advance Precision Medicine. Moreover, a trained workforce is key to taking advantage of new developments in machine learning and artificial intelligence which can be applied across disciplines, to include targeted molecular imaging, photoacoustics, and magnetic resonance imaging (MRI) in terms of data acquisition, image processing, and diagnosis. Such imaging advances are interdisciplinary with technology innovations crossing the physical, biological, and data sciences. These studies start with preclinical mechanistic inquiries using targeted pathology-based imaging in animal disease models, and then expand into human subjects. Human studies include safety testing and the Food and Drug Administration’s (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate goal is to make research innovations widely available to the public and the entire practicing medical community. Although this “bench-to-bedside” process has been widely acclaimed, there remains a knowledge gap in the medical imaging research community as to how to take preclinical research into humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and fellows – often lack the understanding to navigate research regulatory requirements as well as the knowledge base to understand or perform preclinical research that will inform the mechanism of innovation. In this T32 renewal, we have optimized training to provide supportive Mentoring Teams and cover technical advances, research rigor, and the practical aspects of grant submission to better prepare future imaging scientists for the challenges of performing science which impacts healthcare.

项目总结顶层(转译影像教育和研究的培训机会)是临床科学家圣路易斯华盛顿大学博士后培训计划的目的是为学员提供严格的翻译成像研究方面的指导。目标是是让住院医生和其他受训人员为成为成功的独立调查员做好准备，并最终成为各自领域的领导者，开发成像技术和应用程序，从而人类受试者和影响医疗保健。精准医学是一种治疗疾病和考虑到个体在基因、环境和生活方式上的差异的预防。发展指导和监测患者特定治疗的患者特定生物标志物成像方法的方法将是需要推动精密医学的发展。此外，训练有素的劳动力是利用新技术的关键机器学习和人工智能的发展，可以跨学科应用，以包括靶向分子成像、光声学和磁共振成像(MRI) 数据采集、图像处理和诊断。这种成像技术的进步是跨学科的跨越物理、生物和数据科学的技术创新。这些研究始于在动物疾病模型中使用基于病理学的靶向成像的临床前机制调查，以及然后扩展到人类受试者。人体研究包括安全测试和食品和药物美国食品和药物管理局(FDA)的新药研究(IND)和设备豁免(IDE)程序。终极的目标是将研究创新广泛地提供给公众和整个执业医学社区。尽管这种从板凳到床边的过程广受好评，但仍有一种医学影像研究界关于如何开展临床前研究的知识差距人类，以及如何将这些创新带给公众。此外，临床科学家-住院医生和研究员-通常缺乏对驾驭研究法规要求以及了解或执行将为创新机制提供信息的临床前研究的知识库。在此次T32续订中，我们优化了培训，以提供支持性指导团队并涵盖技术进展、研究的严谨性和拨款提交的实际方面，以更好地为未来的成像做准备科学家为执行影响医疗保健的科学所面临的挑战。

项目成果

期刊论文数量（78）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab.

DOI：
10.2217/cns-2021-0013
发表时间：
2022-03-01
期刊：
CNS oncology
影响因子：
0
作者：
Hwang H;Huang J;Khaddour K;Butt OH;Ansstas G;Chen J;Katumba RG;Kim AH;Leuthardt EC;Campian JL
通讯作者：
Campian JL

Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays.