Training OPportunites in Translational Imaging Education and Research (TOP-TIER)

转化成像教育和研究的培训机会（顶级）

基本信息

批准号：
10671722
负责人：
Hongyu An
金额：
$ 23.43万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-07 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10671722
关键词：
Education Research Training image translation

项目摘要

PROJECT SUMMARY TOP-TIER (Training OPportunities in Translational Imaging Education and Research) is a clinician scientist post-doctoral training program at Washington University (WU) in St. Louis designed with the purpose of providing trainees with instruction in the performance of rigorous translational imaging research. The goal is to prepare resident and fellow trainees for careers as successful independent investigators and to ultimately become leaders in their field, developing imaging techniques and applications that translate into human subjects and impact healthcare. Precision Medicine is an approach to disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle. Development of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be needed to advance Precision Medicine. Moreover, a trained workforce is key to taking advantage of new developments in machine learning and artificial intelligence which can be applied across disciplines, to include targeted molecular imaging, photoacoustics, and magnetic resonance imaging (MRI) in terms of data acquisition, image processing, and diagnosis. Such imaging advances are interdisciplinary with technology innovations crossing the physical, biological, and data sciences. These studies start with preclinical mechanistic inquiries using targeted pathology-based imaging in animal disease models, and then expand into human subjects. Human studies include safety testing and the Food and Drug Administration’s (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate goal is to make research innovations widely available to the public and the entire practicing medical community. Although this “bench-to-bedside” process has been widely acclaimed, there remains a knowledge gap in the medical imaging research community as to how to take preclinical research into humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and fellows – often lack the understanding to navigate research regulatory requirements as well as the knowledge base to understand or perform preclinical research that will inform the mechanism of innovation. In this T32 renewal, we have optimized training to provide supportive Mentoring Teams and cover technical advances, research rigor, and the practical aspects of grant submission to better prepare future imaging scientists for the challenges of performing science which impacts healthcare.

项目摘要顶级（翻译成像教育和研究的培训机会）是临床科学家圣路易斯华盛顿大学（WU）的博士后培训计划，目的是为受训者提供严格的翻译成像研究的指示。目标是为居民和学员准备职业，作为成功的独立调查员，并最终成为其领域的领导者，开发成像技术和应用，这些技术和应用转化为人类受试者和影响医疗保健。精密医学是一种疾病治疗的方法和预防考虑基因，环境和生活方式的个人变异性。发展特异性生物标志物成像的方法指导和监测患者特异性疗法的方法需要进步精确药物。此外，训练有素的劳动力是利用新的关键机器学习和人工智能的发展，可以跨学科应用于包括靶向分子成像，光声和磁共振成像（MRI）数据采集，图像处理和诊断。这样的成像进步与跨越物理，生物学和数据科学的技术创新。这些研究以在动物疾病模型中使用基于病理的成像的临床前机械查询，并然后扩展到人类主题。人类研究包括安全测试和食品和药物管理（FDA）调查新药（IND）和设备豁免（IDE）过程。最终目标是使研究创新可为公众和整个实践医疗广泛使用社区。尽管这个“基于床边”的过程已广受赞誉，但仍有一个医学成像研究界的知识差距如何将临床前研究进行人类，以及如何将这些创新带给公众。此外，临床科学家 - 居民和研究员 - 通常缺乏对研究监管要求以及了解或执行临床前研究的知识基础，这将为创新机制提供信息。在此T32续订中，我们进行了优化的培训，以提供支持性指导团队并涵盖技术进步，严格的研究和赠款提交的实际方面，以更好地准备未来的想象力科学家面临影响医疗保健的科学挑战。

项目成果

期刊论文数量（78）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reverse Engineering and 3D Printing of Medical Devices for Drug Delivery and Drug-Embedded Anatomic Implants.

DOI：
10.3390/polym15214306
发表时间：
2023-11-02
期刊：
Polymers
影响因子：
5
作者：
Elumalai A;Nayak Y;Ganapathy AK;Chen D;Tappa K;Jammalamadaka U;Bishop G;Ballard DH
通讯作者：
Ballard DH

"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses.

“不寻常的嫌疑人”——非典型乳腺肿块的乳房X光检查、超声检查和组织病理学表现。

DOI：
10.1016/j.clinimag.2020.04.039
发表时间：
2020
期刊：
Clinical imaging
影响因子：
2.1
作者：
Naeem,Muhammad;Zulfiqar,Maria;Ballard,DavidH;Billadello,Laura;Cao,Guihua;Winter,Andrea;Lowdermilk,Mary
通讯作者：
Lowdermilk,Mary

3D Printed Antibiotic and Chemotherapeutic Eluting Catheters for Potential Use in Interventional Radiology: In Vitro Proof of Concept Study.

DOI：
10.1016/j.acra.2018.03.022
发表时间：
2019-03
期刊：
Academic radiology
影响因子：
4.8
作者：
Weisman JA;Ballard DH;Jammalamadaka U;Tappa K;Sumerel J;D'Agostino HB;Mills DK;Woodard PK
通讯作者：
Woodard PK

Practical considerations for quantitative clinical SPECT/CT imaging of alpha particle emitting radioisotopes.

DOI：
10.7150/thno.63860
发表时间：
2021
期刊：
Theranostics
影响因子：
12.4
作者：
Benabdallah N;Scheve W;Dunn N;Silvestros D;Schelker P;Abou D;Jammalamadaka U;Laforest R;Li Z;Liu J;Ballard DH;Maughan NM;Gay H;Baumann BC;Hobbs RF;Rogers B;Iravani A;Jha AK;Dehdashti F;Thorek DLJ
通讯作者：
Thorek DLJ

Accuracy and Clinical Implications of Preoperative Multidetector CT (MDCT) in Predicting Outcome and Resectability in Patients with Pancreatic Adenocarcinoma.

术前多排 CT (MDCT) 预测胰腺腺癌患者的结果和可切除性的准确性和临床意义。

DOI：
发表时间：
2019
期刊：
The American surgeon
影响因子：
0
作者：
HamidianJahromi,Alireza;Zibari,GaziB;Sangster,Guillermo;Chu,QuyenD;Ballard,DavidH;Shokouh-Amiri,Hosein
通讯作者：
Shokouh-Amiri,Hosein