Postdoctoral Research Training in Anesthesiology and Critical Care Medicine

麻醉学和重症监护医学博士后研究培训

• 批准号: 10411889
• 负责人: Cyrus David Mintz
• 金额: $ 60.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411889
• 关键词: Anesthesiology; Critical Care; Medicine; Research Training

PROJECT SUMMARY Although past advances in the field of Anesthesiology have made perioperative medicine remarkably safe for patients by comparison to historical standards, a myriad of important research questions that hold the keys to further progress in the allied fields of Anesthesia, Critical Care, and Pain Medicine remain unanswered. These questions exist in, but are not limited to, the following domains: (1) The mechanisms of action of anesthetic and sedative medications; (2) The systems biology of the perioperative state; (3) The mechanism and prevention of postoperative delirium and cognitive dysfunction; (4) Potential toxicity of anesthetic agents in the developing brain; (5) Maximization of safety related to human factors and communication throughout the perioperative period; (6) Development and testing of care pathways to improve long-term outcomes after surgery; (7) Sepsis and other causes of organ failure in intensive care; (8) Mechanisms and treatment of acute and chronic pain; and (9) Appropriate use of opioids and addiction prevention in the perioperative setting. To address these and other key questions that have the potential to improve public health, it is critically important to develop a core of well-trained and highly motivated physician-scientists within the Anesthesiology specialty who are dedicated to research and academics. The Department of Anesthesiology and Critical Care Medicine (ACCM) at the Johns Hopkins University (JHU) is submitting this renewal application for continued support of Postdoctoral Research Training in Anesthesiology (PRTA). In addition to providing an avenue for the support of Trainees, this program will continue to refine the approach whereby ACCM recruits talented and diverse young scientists engaged in Anesthesiology research and trains them via rigorous career development plans under the guidance of expert Faculty Mentors. Our principal aim is to develop the next generation of physician- scientists by endowing them with the tools and techniques best suited to their research while fostering innovation and the highest standards of scientific rigor. This aim is accomplished through a strong departmental research infrastructure that operates in conjunction with the incredible breadth and depth of the broader JHU scientific enterprise. Appointments are for two years, and key activities are mentored research and the potential for further education in the form of a relevant master's degree. As demonstrated in this application, ACCM has a long and productive history of clinical, translational, and basic research training in Anesthesiology, which the PRTA will continue to build upon and improve. Our previous success is highlighted by the career progression and scientific accomplishments of past Trainees, and our ongoing capacity to fulfill the mission of this Program is apparent in our outstanding pool of current and potential Trainees. We request continued funding for six Trainees per year for the so that we can continue to develop physician-scientists who will contribute to a secure scientific future in the field of Anesthesiology.

项目总结 尽管麻醉学领域过去的进步使围手术期药物非常安全 与历史标准相比，无数重要的研究问题掌握着 麻醉、重症监护和止痛药等相关领域的进一步进展仍未得到回答。这些 问题存在于以下领域，但不限于：(1)麻醉剂的作用机制 和镇静药物；(2)围手术期状态的系统生物学；(3)机制和 预防术后精神错乱和认知功能障碍；(4)麻醉药物的潜在毒性 开发大脑；(5)最大限度地提高与人的因素和整个过程中的沟通有关的安全性 围手术期；(6)开发和测试护理路径，以改善术后的长期结果 外科；(7)脓毒症和重症监护中器官衰竭的其他原因；(8)急性 和慢性疼痛；以及(9)围手术期适当使用阿片类药物和预防成瘾。至 解决这些和其他有可能改善公共卫生的关键问题，至关重要 在麻醉学专业内培养一支训练有素、积极进取的内科科学家队伍 他们致力于研究和学术研究。麻醉学和重症监护医学系 约翰霍普金斯大学(JHU)的(ACCM)正在提交续订申请，以继续支持 麻醉学博士后研究培训(PRTA)除了提供支持的途径之外 对于学员，该计划将继续完善ACCM招聘有才华和多样化的人员的方法 青年科学家从事麻醉学研究，并通过严格的职业发展计划对他们进行培训 在专家教师的指导下。我们的主要目标是培养下一代医生- 科学家通过赋予他们最适合他们研究的工具和技术，同时促进 创新和最高标准的科学严谨。这一目标是通过强有力的 与令人难以置信的广度和深度的 更广泛的JHU科学事业。聘期为两年，主要活动是指导研究 以及以相关硕士学位的形式继续深造的潜力。如本图所示 应用，ACCM在临床、翻译和基础研究培训方面有着悠久而富有成效的历史 麻醉学，PRTA将继续在此基础上发展和改进。我们以前的成功被突出显示 通过过去学员的职业发展和科学成就，以及我们正在进行的能力来实现 这一计划的使命在我们优秀的现有和潜在学员库中显而易见。我们请求 继续资助每年6名实习生，以便我们能够继续培养 将为麻醉学领域的安全科学未来做出贡献。