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Postdoctoral Research Training in Anesthesiology and Critical Care Medicine

麻醉学和重症监护医学博士后研究培训

基本信息

批准号：
10651671
负责人：
Cyrus David Mintz
金额：
$ 61.49万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10651671
关键词：
Anesthesiology Critical Care Medicine Postdoctoral Fellow Research Training

项目摘要

PROJECT SUMMARY Although past advances in the field of Anesthesiology have made perioperative medicine remarkably safe for patients by comparison to historical standards, a myriad of important research questions that hold the keys to further progress in the allied fields of Anesthesia, Critical Care, and Pain Medicine remain unanswered. These questions exist in, but are not limited to, the following domains: (1) The mechanisms of action of anesthetic and sedative medications; (2) The systems biology of the perioperative state; (3) The mechanism and prevention of postoperative delirium and cognitive dysfunction; (4) Potential toxicity of anesthetic agents in the developing brain; (5) Maximization of safety related to human factors and communication throughout the perioperative period; (6) Development and testing of care pathways to improve long-term outcomes after surgery; (7) Sepsis and other causes of organ failure in intensive care; (8) Mechanisms and treatment of acute and chronic pain; and (9) Appropriate use of opioids and addiction prevention in the perioperative setting. To address these and other key questions that have the potential to improve public health, it is critically important to develop a core of well-trained and highly motivated physician-scientists within the Anesthesiology specialty who are dedicated to research and academics. The Department of Anesthesiology and Critical Care Medicine (ACCM) at the Johns Hopkins University (JHU) is submitting this renewal application for continued support of Postdoctoral Research Training in Anesthesiology (PRTA). In addition to providing an avenue for the support of Trainees, this program will continue to refine the approach whereby ACCM recruits talented and diverse young scientists engaged in Anesthesiology research and trains them via rigorous career development plans under the guidance of expert Faculty Mentors. Our principal aim is to develop the next generation of physician- scientists by endowing them with the tools and techniques best suited to their research while fostering innovation and the highest standards of scientific rigor. This aim is accomplished through a strong departmental research infrastructure that operates in conjunction with the incredible breadth and depth of the broader JHU scientific enterprise. Appointments are for two years, and key activities are mentored research and the potential for further education in the form of a relevant master's degree. As demonstrated in this application, ACCM has a long and productive history of clinical, translational, and basic research training in Anesthesiology, which the PRTA will continue to build upon and improve. Our previous success is highlighted by the career progression and scientific accomplishments of past Trainees, and our ongoing capacity to fulfill the mission of this Program is apparent in our outstanding pool of current and potential Trainees. We request continued funding for six Trainees per year for the so that we can continue to develop physician-scientists who will contribute to a secure scientific future in the field of Anesthesiology.

项目摘要尽管麻醉学领域过去的进展使围手术期药物对患者非常安全，病人通过比较历史标准，无数的重要研究问题，掌握了关键，在麻醉、重症监护和疼痛医学的相关领域的进一步进展仍然没有答案。这些存在的问题，但不限于，以下领域：（1）麻醉剂的作用机制和镇静药物;（2）围手术期状态的系统生物学;（3）机制和预防术后谵妄和认知功能障碍;（4）麻醉剂在手术中的潜在毒性开发大脑;（5）最大限度地提高与人为因素和整个通信有关的安全性围手术期;（6）制定和测试护理路径，以改善术后的长期结局外科手术;（7）重症监护中的脓毒症和其他器官衰竭原因;（8）急性和慢性疼痛;（9）在围手术期适当使用阿片类药物和预防成瘾。到解决这些和其他有可能改善公共卫生的关键问题，在麻醉学专业内培养一支训练有素、积极主动的医生科学家核心队伍他们致力于研究和学术。麻醉学和重症监护医学系（ACCM）在约翰霍普金斯大学（JHU）提交此更新申请，以继续支持麻醉学博士后研究培训（PRTA）。除了提供一个支持的渠道，该计划将继续完善ACCM招募人才和多样化人才的方法。从事麻醉学研究的年轻科学家，并通过严格的职业发展计划对他们进行培训在专家导师的指导下。我们的主要目标是培养下一代医生- 科学家通过赋予他们最适合他们的研究工具和技术，同时培养创新和科学严谨的最高标准。这一目标是通过一个强大的部门研究基础设施与令人难以置信的广度和深度相结合更广泛的JHU科学事业。培训为期两年，主要活动是指导研究以及以相关硕士学位的形式接受进一步教育的潜力。正如这一点所表明的那样， ACCM在临床、转化和基础研究培训方面有着悠久而富有成效的历史，麻醉学，PRTA将继续建立和改进。我们以前的成功是突出的过去的受训者的职业发展和科学成就，以及我们不断实现的能力，该计划的使命在我们优秀的现有和潜在的受训人员中显而易见。我们要求继续每年资助6名受训人员，以便我们能够继续培养将有助于麻醉学领域的安全科学未来。