Enhancement Training for the Next Generation of Translational Ph.D. Scientists

下一代转化博士的强化培训

• 批准号: 10413926
• 负责人: Alisa S. Wolberg
• 金额: $ 19.26万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413926
• 关键词: Doctor of Philosophy; Scientist; Training; next generation

Project Summary/Abstract In this revision of T32-GM122741, the UNC Program in Translational Medicine requests five years of support to train basic science Ph.D. students to perform translational research on topics of clinical significance, working in multidisciplinary teams composed of scientists, physician-scientists, and clinicians, using state-of-the-art experimental approaches and patient-derived resources to address clinically-relevant needs. The UNC Program in Translational Medicine was born out of the Med-into-Grad Initiative of the Howard Hughes Medical Institute and has now existed for >10 years. Over this period of time, the UNC Program in Translational Medicine has trained 121 Ph.D. students from 15 different basic science programs in the UNC School of Medicine, UNC School of Pharmacy, UNC School of Dentistry, UNC School of Public Health, and UNC College of Arts and Sciences. The UNC Program in Translational Medicine provides enhancement training to biomedical Ph.D. students leading to a Certificate in Translational Medicine which is conferred at the time of completion of the Ph.D. Trainees in the UNC Program in Translational Medicine complete required coursework related to the pathogenesis of human disease, participate in monthly programmatic activities, perform translational research, and benefit from dual mentorship (with a basic science mentor and a clinical co-mentor). The clinical co-mentors provide a tailored clinical experience for each trainee, exposing students to the practical realities of the diseases they research and identifying questions of clinical significance that can be addressed using basic science research methods and approaches. The required elements of the program complement requirements of the individual Ph.D. programs, ensuring that the time-to-completion of the degree is comparable to that of the typical Ph.D. student. Since its inception, 66 Ph.D. students have completed the requirements for the Certificate in Translational Medicine. The long-term goal of the UNC Program in Translational Medicine is to train a cadre of Ph.D. researchers with the knowledge and skills necessary to recognize, appreciate, and address clinically-relevant biological problems from the perspective of basic science. We anticipate that this next generation of translational Ph.D. scientists will understand which biological problems are of greatest clinical relevance and will be positioned to apply new biological knowledge to create tools for improved human health.

项目摘要/摘要 在T32-GM122741的这一修订中，转化医学中的UNC计划要求提供五年的支持 培训基础科学博士学生对临床意义的主题进行翻译研究 在由科学家，医师科学家和临床医生组成的多学科团队中，使用最先进的 实验方法和患者衍生的资源，以满足临床上的相关需求。 UNC 转化医学计划是源于霍华德·休斯医疗的Med-Into-Grad倡议 研究所已经存在> 10年。在此期间，转化中的UNC计划 医学已培训121博士学位。来自UNC学校的15个不同基础科学课程的学生 医学，UNC药学院，UNC牙科学院，UNC公共卫生学院和UNC学院 艺术和科学。转化医学领域的UNC计划为 生物医学博士导致转化医学证书的学生 博士学位完成转化医学中UNC计划的学员完成必需的课程 与人类疾病的发病机理有关，参加每月程序活动，进行 转化研究，并受益于双重指导（带基础科学指导者和临床同事）。 临床院长为每个学员提供量身定制的临床经验，使学生暴露于 他们研究的疾病的实践现实，并确定可以是临床意义的问题 使用基础科学研究方法和方法解决。该程序的所需元素 个人博士的补充要求程序，确保学位的完成时间 与典型的博士学位相当。学生。自成立以来，66博士学位学生已经完成 转化医学证书的要求。 UNC计划的长期目标 翻译医学将培训博士学位的干部。具有所需的知识和技能的研究人员 从基本的角度来认识，欣赏和解决与临床相关的生物学问题 科学。我们预计下一代翻译博士学位科学家会了解哪个 生物学问题具有最大的临床相关性，并将定位用于应用新的生物学知识 为改善人类健康而创建工具。

项目成果

Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents.

• DOI: 10.1111/cts.12803
• 发表时间: 2020-11
• 期刊: Clinical and translational science
• 作者: Ge S;Mendley SR;Gerhart JG;Melloni C;Hornik CP;Sullivan JE;Atz A;Delmore P;Tremoulet A;Harper B;Payne E;Lin S;Erinjeri J;Cohen-Wolkowiez M;Gonzalez D;Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee
• 通讯作者: Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

A cross-institutional analysis of the effects of broadening trainee professional development on research productivity.

• DOI: 10.1371/journal.pbio.3000956
• 发表时间: 2021-07
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Brandt PD;Sturzenegger Varvayanis S;Baas T;Bolgioni AF;Alder J;Petrie KA;Dominguez I;Brown AM;Stayart CA;Singh H;Van Wart A;Chow CS;Mathur A;Schreiber BM;Fruman DA;Bowden B;Wiesen CA;Golightly YM;Holmquist CE;Arneman D;Hall JD;Hyman LE;Gould KL;Chalkley R;Brennwald PJ;Layton RL
• 通讯作者: Layton RL

Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.

• DOI: 10.1002/cpt.1990
• 发表时间: 2021-01
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7
• 作者: Salerno SN;Edginton A;Gerhart JG;Laughon MM;Ambalavanan N;Sokol GM;Hornik CD;Stewart D;Mills M;Martz K;Gonzalez D;Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee
• 通讯作者: Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.

• DOI: 10.1007/s40262-021-01072-4
• 发表时间: 2022-03
• 期刊: Clinical pharmacokinetics
• 影响因子: 4.5
• 作者: Gerhart JG;Carreño FO;Edginton AN;Sinha J;Perrin EM;Kumar KR;Rikhi A;Hornik CP;Harris V;Ganguly S;Cohen-Wolkowiez M;Gonzalez D;Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
• 通讯作者: Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee