Enhancement Training for the Next Generation of Translational Ph.D. Scientists

下一代转化博士的强化培训

• 批准号: 10413926
• 负责人: Alisa S. Wolberg
• 金额: $ 19.26万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413926
• 关键词: Doctor of Philosophy; Scientist; Training; next generation

Project Summary/Abstract In this revision of T32-GM122741, the UNC Program in Translational Medicine requests five years of support to train basic science Ph.D. students to perform translational research on topics of clinical significance, working in multidisciplinary teams composed of scientists, physician-scientists, and clinicians, using state-of-the-art experimental approaches and patient-derived resources to address clinically-relevant needs. The UNC Program in Translational Medicine was born out of the Med-into-Grad Initiative of the Howard Hughes Medical Institute and has now existed for >10 years. Over this period of time, the UNC Program in Translational Medicine has trained 121 Ph.D. students from 15 different basic science programs in the UNC School of Medicine, UNC School of Pharmacy, UNC School of Dentistry, UNC School of Public Health, and UNC College of Arts and Sciences. The UNC Program in Translational Medicine provides enhancement training to biomedical Ph.D. students leading to a Certificate in Translational Medicine which is conferred at the time of completion of the Ph.D. Trainees in the UNC Program in Translational Medicine complete required coursework related to the pathogenesis of human disease, participate in monthly programmatic activities, perform translational research, and benefit from dual mentorship (with a basic science mentor and a clinical co-mentor). The clinical co-mentors provide a tailored clinical experience for each trainee, exposing students to the practical realities of the diseases they research and identifying questions of clinical significance that can be addressed using basic science research methods and approaches. The required elements of the program complement requirements of the individual Ph.D. programs, ensuring that the time-to-completion of the degree is comparable to that of the typical Ph.D. student. Since its inception, 66 Ph.D. students have completed the requirements for the Certificate in Translational Medicine. The long-term goal of the UNC Program in Translational Medicine is to train a cadre of Ph.D. researchers with the knowledge and skills necessary to recognize, appreciate, and address clinically-relevant biological problems from the perspective of basic science. We anticipate that this next generation of translational Ph.D. scientists will understand which biological problems are of greatest clinical relevance and will be positioned to apply new biological knowledge to create tools for improved human health.

项目摘要/摘要 在T32-GM122741的这个修订版中，北卡罗来纳大学的转化医学计划要求提供五年的支持 培养基础科学博士生在有临床意义的课题上进行翻译研究，工作 在由科学家、内科科学家和临床医生组成的多学科团队中，使用最先进的 解决临床相关需求的实验方法和患者衍生资源。北卡罗来纳大学 转化医学项目诞生于霍华德·休斯医学中心的医学毕业计划 该研究所成立至今已有10年之久。在这段时间里，北卡罗来纳大学的翻译计划 在北卡罗来纳大学医学院，医学已经培训了来自15个不同基础科学项目的121名博士生 医学院、北卡罗来纳大学药学院、北卡罗来纳大学牙科学院、北卡罗来纳大学公共卫生学院和北卡罗来纳大学学院 文理学院。北卡罗来纳大学转化医学计划提供增强培训，以 生物医学博士生获得转化医学证书时， 完成北卡罗来纳大学转化医学计划的博士生完成必修课程 与人类疾病的发病机制有关，参加每月的节目活动，表演 翻译研究，并受益于双重导师(有一个基础科学导师和一个临床共同导师)。 临床合作导师为每个实习生提供量身定制的临床体验，让学生接触到 他们研究的疾病的实际情况，并确定可能具有临床意义的问题 使用基础科学研究方法和方法解决的问题。计划所需的要素 补充个人博士课程的要求，确保完成学位的时间 可以与典型的博士生相媲美。自成立以来，已有66名博士研究生完成了 转化医学证书的要求。北卡罗来纳大学项目的长期目标是 转化医学是培养一批具有以下必要知识和技能的博士生研究人员 从基础知识的角度认识、理解和解决与临床相关的生物学问题 科学。我们预计，下一代翻译博士科学家将理解哪些 生物学问题具有最大的临床相关性，并将定位于应用新的生物学知识 创造出改善人类健康的工具。

项目成果

Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents.

• DOI: 10.1111/cts.12803
• 发表时间: 2020-11
• 期刊: Clinical and translational science
• 作者: Ge S;Mendley SR;Gerhart JG;Melloni C;Hornik CP;Sullivan JE;Atz A;Delmore P;Tremoulet A;Harper B;Payne E;Lin S;Erinjeri J;Cohen-Wolkowiez M;Gonzalez D;Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee
• 通讯作者: Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

A cross-institutional analysis of the effects of broadening trainee professional development on research productivity.

• DOI: 10.1371/journal.pbio.3000956
• 发表时间: 2021-07
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Brandt PD;Sturzenegger Varvayanis S;Baas T;Bolgioni AF;Alder J;Petrie KA;Dominguez I;Brown AM;Stayart CA;Singh H;Van Wart A;Chow CS;Mathur A;Schreiber BM;Fruman DA;Bowden B;Wiesen CA;Golightly YM;Holmquist CE;Arneman D;Hall JD;Hyman LE;Gould KL;Chalkley R;Brennwald PJ;Layton RL
• 通讯作者: Layton RL

Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.

• DOI: 10.1002/cpt.1990
• 发表时间: 2021-01
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7
• 作者: Salerno SN;Edginton A;Gerhart JG;Laughon MM;Ambalavanan N;Sokol GM;Hornik CD;Stewart D;Mills M;Martz K;Gonzalez D;Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee
• 通讯作者: Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.

• DOI: 10.1007/s40262-021-01072-4
• 发表时间: 2022-03
• 期刊: Clinical pharmacokinetics
• 影响因子: 4.5
• 作者: Gerhart JG;Carreño FO;Edginton AN;Sinha J;Perrin EM;Kumar KR;Rikhi A;Hornik CP;Harris V;Ganguly S;Cohen-Wolkowiez M;Gonzalez D;Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee
• 通讯作者: Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee