Core C: Translational Neurosciences Core

核心 C：转化神经科学核心

• 批准号: 10415085
• 负责人: Laurie E Cutting
• 金额: $ 20.93万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10415085
• 关键词: Academic Medical Centers; Address; Affect; Algorithms; Area; Behavioral; Big Data; Biological Markers; Caregivers; Categories; Child; Clinical; Communities; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Discipline; Disease; Down Syndrome; Education; Electroencephalogram; Ensure; Event-Related Potentials; Experimental Designs; Faculty; Funding; Goals; High Performance Computing; Human; Image; Individual; Infant; Institutes; Intellectual Interest; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Lead; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Mission; Modality; Morphologic artifacts; Motion; Movement; Persons; Population; Prevention; Protocols documentation; Psychophysiology; Research; Research Design; Research Personnel; Resources; Scanning; Science; Scientist; Services; Site; Source; Special Population; Technical Expertise; Techniques; Testing; Time; Translations; Universities; Work; analysis pipeline; autism spectrum disorder; base; big-data science; cluster computing; cost effective; cost efficient; data acquisition; data de-identification; data management; data pipeline; data repository; design; disability; image processing; imaging capabilities; improved; individualized medicine; innovation; interdisciplinary collaboration; member; mouse model; neuroimaging; neurophysiology; novel; programs; public health relevance; relating to nervous system; repository; targeted treatment; tool; translational neuroscience; visual tracking

The Translational Neuroscience Core will: 1) provide IDDRC investigators with facilities and services to support their individual human neuroimaging and psychophysiological research programs in the area of intellectual and developmental disabilities (IDD); 2) continue to develop trans-species methods for acquiring neuroimaging and psychophysiological measures in humans with IDD and IDD mouse models; 3) utilize repositories of ‘big data’ at Vanderbilt to develop new tools and discoveries for IDD; 4) facilitate interdisciplinary collaborations among IDDRC investigators who may or may not have neuroimaging expertise; and 5) ensure that the services provided are timely, highest quality, and cost-effective. The Translational Neuroscience Core C will support P50 users in the above areas for magnetic resonance (MR) neuroimaging as well as psychophysiological measures. The Core’s services can be broadly construed into two different categories: (1) those that are responsive to investigators’ needs and (2) those that are generative, and provide new directions in IDD for investigators to leverage. Investigator need-based services provided include assistance in (a) experimental design, including selecting appropriate tasks for magnetic resonance imaging (MRI) or electroencephalogram (EEG)/event-related potentials (ERP), (b) identification of the optimal modalities of MR imaging or EEG/ERP/eye tracking acquisition parameters (c) implementation of MRI and EEG/ERP data collection with special populations (individuals with various IDDs, especially infants and children), and (d) management and analysis of MRI and EEG/ERP/eye tracking data. The generative and innovative component of the Translational Neuroscience Core C focuses on key areas that are of particular interest for IDD researchers: design of novel experimental paradigms optimized for IDDs, expanding trans-species imaging capabilities, implementing and augmenting novel data acquisition and analysis methods for measuring neural biomarkers of IDD, developing robust image processing techniques to handle challenging data (e.g., movement artifacts), and providing tools to enable optimal establishment, usage, and analysis of ‘big data’ repositories such as ImageVU. While expertise and resources in neuroimaging, advanced computing, and data management tools are available at Vanderbilt University, none are tailored for the special needs of those who study IDDs. The Aims and services in Core C all have the central goal: facilitate cost-efficient discovery that leads to the prevention and/or amelioration of IDD. Each member of the Core has strong ties to the larger Vanderbilt community, thus enabling seamless linkages between entities at Vanderbilt that are critical for the Core. The Core will serve 22 funded IDD research-related projects.

翻译神经科学核心将：1）为IDDRC研究者提供设施和服务，以支持 他们的个人人类神经成像和心理生理学研究计划，在智力和 发展障碍（IDD）; 2）继续开发跨物种的方法来获取神经成像， IDD患者和IDD小鼠模型的心理生理学测量; 3）利用“大数据”库 在范德比尔特开发新的工具和发现IDD; 4）促进跨学科合作， IDDRC研究人员可能具有或不具有神经影像学专业知识;以及5）确保服务 提供及时、最高质量和具有成本效益的服务。翻译神经科学核心C将支持 P50用户在上述领域的磁共振（MR）神经成像以及心理生理 措施核心的服务可以大致分为两类：（1） 对研究者的需求作出反应;（2）具有生成性，并为IDD提供新的方向 供调查人员利用提供的基于研究者需求的服务包括： 设计，包括为磁共振成像（MRI）或脑电图选择适当的任务 (EEG)/事件相关电位（ERP），（B）识别MR成像的最佳模式，或 EEG/ERP/眼跟踪采集参数（c）MRI和EEG/ERP数据采集的实施， 特殊人群（患有各种缺碘症的个人，特别是婴儿和儿童），以及（d）管理和 MRI和EEG/ERP/眼动追踪数据分析。的创造性和创新性的组成部分， 翻译神经科学核心C集中在IDD研究人员特别感兴趣的关键领域： 设计针对IDDs优化的新实验范例，扩展跨物种成像能力， 实施和增强新的数据采集和分析方法，用于测量神经生物标志物， IDD，开发强大的图像处理技术来处理具有挑战性的数据（例如，运动伪像）， 并提供工具，以实现“大数据”存储库的最佳建立，使用和分析，例如 ImageVU。虽然在神经成像、高级计算和数据管理工具方面的专业知识和资源 虽然范德比尔特大学提供了一些，但没有一个是为那些研究IDDs的人的特殊需要量身定制的。 核心C中的目标和服务都有一个中心目标：促进经济高效的发现， 预防和/或改善IDD。核心的每个成员都与更大的范德比尔特有着密切的联系 社区，从而使范德比尔特的实体之间的无缝连接，这对核心至关重要。的 该中心将为22个获资助的缺碘症研究项目提供服务。