6/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium Vanderbilt

6/6 六溴环十二烷产前经历和纵向发展 (PRELUDE) 联盟范德比尔特

• 批准号: 10748148
• 负责人: Laurie E Cutting
• 金额: $ 31.74万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10748148
• 关键词: Administrative Supplement; Alcohols; Anxiety; Behavior; Behavioral; Biological; Biology; Brain; Cannabis; Caregivers; Child; Child Development; Child Health; Childhood; Cognition; Cognitive; Collaborations; Collection; Communities; Complex; Congenital Abnormality; Data Collection; Detection; Development; Education; Epigenetic Process; Etiology; Evaluation; Exposure to; Family; Fetal Growth; Fetal Reduction; Fetus; Funding; Future; Generations; Genetic; Goals; Health; Healthcare; Heavy Metals; Helping to End Addiction Long-term; Immune; Individual; Infant Health; Infrastructure; Knowledge; Language Delays; Language Development; Link; Longitudinal Studies; Low Birth Weight Infant; Maternal Health; Mediating; Memory impairment; Metabolic; National Institute of Drug Abuse; Neonatal Abstinence Syndrome; Opioid; Outcome; Parents; Participant; Pathogenicity; Placenta; Policies; Predisposition; Pregnancy; Pregnant Women; Premature Birth; Prenatal care; Prevention; Prevention strategy; Process; Proteins; Protocols documentation; Psychopathology; Research Support; Resources; Risk; Sampling; Signaling Protein; Site; Specimen; Tissue Banks; Tissues; Tobacco; Trauma; Umbilical Cord Blood; Umbilical cord structure; United States; United States National Institutes of Health; adverse outcome; alcohol consumption during pregnancy; emotion regulation; fetal; fetal opioid exposure; fetal substance exposure; in utero; inattention; innovation; interest; longitudinal, prospective study; mRNA Expression; maternal opioid use; neonatal health; neurodevelopment; neuroimaging; nutrition; opioid use; opioid use disorder; opioid use in pregnancy; patients who use opioids; polysubstance use; pregnant; prenatal; prenatal experience; protocol development; racism; response; social; substance use; success; toxicant

PROJECT SUMMARY/ABSTRACT Opioid use during pregnancy is widespread and associated with adverse outcomes for the pregnant individual and the developing child. Prenatal opioid exposure is associated with a wide range of negative fetal and child outcomes including reduced fetal growth, premature birth, lower birth weight, congenital defects, increased neonatal healthcare, and heightened risk for later behavioral (e.g., anxiety, inattention), cognitive (e.g., memory deficits, delayed language acquisition), and metabolic problems. Despite opioid use being linked to adverse maternal, fetal, and child outcomes, the mechanisms through which these arise and the potential consequences of prenatal opioid exposure for child health and development (e.g., brain and behavior) remain largely unexplored. This lack of etiologic knowledge has contributed to stagnant treatment, prevention, and mitigation efforts leaving individuals and families susceptible to reverberating adverse outcomes. The HEALthy Brain and Child Development (HBCD) Study is a 25-site longitudinal prospective study of early child development in the US that will assess a broad spectrum of biological (e.g., neuroimaging, genetics, epigenetics), behavioral (e.g., cognition and emotional regulation), experiential (e.g., trauma), social (e.g., racism), and health (e.g., psychopathology) factors among ~7,500 nationally-representative pregnant women and their children from pregnancy to mid-childhood. A major goal of the HBCD study is to increase understanding of the potential consequences of prenatal substance exposures. It will be enriched for maternal substance use during pregnancy (i.e., ~25% of the sample will be using opioids, cannabis, alcohol, and/or tobacco during pregnancy and 12% of the total sample will be using opioids) and offers a unique opportunity to inform our understanding of how the adverse consequences associated with opioid use during pregnancy arise. Although HBCD will be the largest long-term study of early brain and child development outcomes in the US, the core protocol does not include the collection of delivery biospecimens. This Administrative Supplement in response to the NIDA/ORWH Administrative Supplement Notice of Special Interests: HEAL Initiative: Biospecimen Collection in Pregnancy (NOT-DA-23-005) proposes to leverage the HEALthy Brain and Child Development (HBCD) by expanding the biospecimen collection of the Core HBCD Protocol to include delivery specimens (placenta, cord tissue, cord blood). Delivery samples will be collected from a representative sample of HBCD Study participants across up to 14 sites (and over 2,000 participants across HBCD sites submitting applications in response to this NOSI). This will provide an unprecedented resource generating opportunity for a larger scientific community to comprehensively evaluate pathophysiological mechanisms that mediate the connection between opioid and polysubstance use during pregnancy and adverse neonatal, infant, and/or maternal health outcomes and, in turn, inform innovative preventive strategies.

项目概要/摘要 怀孕期间阿片类药物的使用很普遍，并且与孕妇的不良后果相关 和正在发育的孩子。产前阿片类药物暴露与胎儿和儿童的多种阴性结果有关 结果包括胎儿生长迟缓、早产、出生体重降低、先天缺陷、体重增加 新生儿保健，以及后期行为（例如焦虑、注意力不集中）、认知（例如记忆力）的风险增加 缺陷、语言习得延迟）和代谢问题。尽管阿片类药物的使用与不良反应有关 孕产妇、胎儿和儿童的结果、这些结果发生的机制以及潜在的可能性 产前接触阿片类药物对儿童健康和发育（例如大脑和行为）的影响仍然存在 很大程度上尚未探索。病因学知识的缺乏导致了治疗、预防和治疗的停滞。 缓解努力使个人和家庭容易受到不利后果的影响。 健康大脑与儿童发育 (HBCD) 研究是一项 25 个中心的纵向前瞻性研究 美国儿童发展将评估广泛的生物学（例如神经影像学、遗传学、 表观遗传学）、行为（例如认知和情绪调节）、体验（例如创伤）、社会（例如 约 7,500 名具有全国代表性的孕妇中的种族歧视）和健康（例如精神病理学）因素 以及他们从怀孕到童年中期的孩子。 HBCD 研究的一个主要目标是增加 了解产前接触物质的潜在后果。将会丰富妈妈们的生活 怀孕期间使用药物（即约 25% 的样本将使用阿片类药物、大麻、酒精和/或 怀孕期间吸烟，总样本的 12% 将使用阿片类药物），并提供了一个独特的机会 让我们了解怀孕期间使用阿片类药物所带来的不良后果 出现。尽管六溴环十二烷将是世界上规模最大的关于早期大脑和儿童发育结果的长期研究 美国的核心协议不包括交付生物样本的收集。本行政补充 响应 NIDA/ORWH 特殊利益行政补充通知：HEAL 倡议： 妊娠期生物样本采集 (NOT-DA-23-005) 建议利用健康的大脑和儿童 通过扩大核心六溴环十二烷协议的生物样本收集以包括交付来进行开发（六溴环十二烷） 标本（胎盘、脐带组织、脐带血）。交付样品将从代表性样品中采集 多达 14 个地点的 HBCD 研究参与者（以及 HBCD 地点超过 2,000 名参与者提交的 响应此 NOSI 的申请）。这将为我们提供前所未有的资源生成机会 更大的科学界来全面评估介导的病理生理机制 怀孕期间阿片类药物和多种物质的使用与新生儿、婴儿和/或不良婴儿之间的联系 孕产妇健康成果，反过来又为创新预防策略提供信息。