Core C: Translational Neurosciences Core

核心 C：转化神经科学核心

• 批准号: 10085554
• 负责人: Laurie E Cutting
• 金额: $ 22.73万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085554
• 关键词: Academic Medical Centers; Address; Affect; Algorithms; Area; Behavioral; Big Data; Biological Markers; Caregivers; Categories; Child; Clinical; Communities; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Discipline; Disease; Down Syndrome; Education; Electroencephalogram; Ensure; Event-Related Potentials; Experimental Designs; Faculty; Funding; Goals; High Performance Computing; Human; Image; Individual; Infant; Institutes; Intellectual Interest; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Lead; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Mission; Modality; Morphologic artifacts; Motion; Movement; Population; Prevention; Protocols documentation; Psychophysiology; Research; Research Design; Research Personnel; Resources; Scanning; Science; Scientist; Services; Site; Source; Technical Expertise; Techniques; Testing; Time; Translations; Universities; Work; analysis pipeline; autism spectrum disorder; base; big-data science; cluster computing; cost effective; cost efficient; data acquisition; data de-identification; data management; data pipeline; data warehouse; design; disability; image processing; imaging capabilities; improved; individualized medicine; innovation; interdisciplinary collaboration; member; mouse model; named group; neuroimaging; neurophysiology; novel; programs; public health relevance; relating to nervous system; repository; targeted treatment; tool; translational neuroscience; visual tracking

The Translational Neuroscience Core will: 1) provide IDDRC investigators with facilities and services to support their individual human neuroimaging and psychophysiological research programs in the area of intellectual and developmental disabilities (IDD); 2) continue to develop trans-species methods for acquiring neuroimaging and psychophysiological measures in humans with IDD and IDD mouse models; 3) utilize repositories of ‘big data’ at Vanderbilt to develop new tools and discoveries for IDD; 4) facilitate interdisciplinary collaborations among IDDRC investigators who may or may not have neuroimaging expertise; and 5) ensure that the services provided are timely, highest quality, and cost-effective. The Translational Neuroscience Core C will support P50 users in the above areas for magnetic resonance (MR) neuroimaging as well as psychophysiological measures. The Core’s services can be broadly construed into two different categories: (1) those that are responsive to investigators’ needs and (2) those that are generative, and provide new directions in IDD for investigators to leverage. Investigator need-based services provided include assistance in (a) experimental design, including selecting appropriate tasks for magnetic resonance imaging (MRI) or electroencephalogram (EEG)/event-related potentials (ERP), (b) identification of the optimal modalities of MR imaging or EEG/ERP/eye tracking acquisition parameters (c) implementation of MRI and EEG/ERP data collection with special populations (individuals with various IDDs, especially infants and children), and (d) management and analysis of MRI and EEG/ERP/eye tracking data. The generative and innovative component of the Translational Neuroscience Core C focuses on key areas that are of particular interest for IDD researchers: design of novel experimental paradigms optimized for IDDs, expanding trans-species imaging capabilities, implementing and augmenting novel data acquisition and analysis methods for measuring neural biomarkers of IDD, developing robust image processing techniques to handle challenging data (e.g., movement artifacts), and providing tools to enable optimal establishment, usage, and analysis of ‘big data’ repositories such as ImageVU. While expertise and resources in neuroimaging, advanced computing, and data management tools are available at Vanderbilt University, none are tailored for the special needs of those who study IDDs. The Aims and services in Core C all have the central goal: facilitate cost-efficient discovery that leads to the prevention and/or amelioration of IDD. Each member of the Core has strong ties to the larger Vanderbilt community, thus enabling seamless linkages between entities at Vanderbilt that are critical for the Core. The Core will serve 22 funded IDD research-related projects.

转化神经科学核心将：1)为IDDRC研究人员提供设施和服务支持