Core C: Translational Neurosciences Core

核心 C：转化神经科学核心

• 批准号: 10085554
• 负责人: Laurie E Cutting
• 金额: $ 22.73万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085554
• 关键词: Academic Medical Centers; Address; Affect; Algorithms; Area; Behavioral; Big Data; Biological Markers; Caregivers; Categories; Child; Clinical; Communities; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Discipline; Disease; Down Syndrome; Education; Electroencephalogram; Ensure; Event-Related Potentials; Experimental Designs; Faculty; Funding; Goals; High Performance Computing; Human; Image; Individual; Infant; Institutes; Intellectual Interest; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Lead; Machine Learning; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Mission; Modality; Morphologic artifacts; Motion; Movement; Population; Prevention; Protocols documentation; Psychophysiology; Research; Research Design; Research Personnel; Resources; Scanning; Science; Scientist; Services; Site; Source; Technical Expertise; Techniques; Testing; Time; Translations; Universities; Work; analysis pipeline; autism spectrum disorder; base; big-data science; cluster computing; cost effective; cost efficient; data acquisition; data de-identification; data management; data pipeline; data warehouse; design; disability; image processing; imaging capabilities; improved; individualized medicine; innovation; interdisciplinary collaboration; member; mouse model; named group; neuroimaging; neurophysiology; novel; programs; public health relevance; relating to nervous system; repository; targeted treatment; tool; translational neuroscience; visual tracking

The Translational Neuroscience Core will: 1) provide IDDRC investigators with facilities and services to support their individual human neuroimaging and psychophysiological research programs in the area of intellectual and developmental disabilities (IDD); 2) continue to develop trans-species methods for acquiring neuroimaging and psychophysiological measures in humans with IDD and IDD mouse models; 3) utilize repositories of ‘big data’ at Vanderbilt to develop new tools and discoveries for IDD; 4) facilitate interdisciplinary collaborations among IDDRC investigators who may or may not have neuroimaging expertise; and 5) ensure that the services provided are timely, highest quality, and cost-effective. The Translational Neuroscience Core C will support P50 users in the above areas for magnetic resonance (MR) neuroimaging as well as psychophysiological measures. The Core’s services can be broadly construed into two different categories: (1) those that are responsive to investigators’ needs and (2) those that are generative, and provide new directions in IDD for investigators to leverage. Investigator need-based services provided include assistance in (a) experimental design, including selecting appropriate tasks for magnetic resonance imaging (MRI) or electroencephalogram (EEG)/event-related potentials (ERP), (b) identification of the optimal modalities of MR imaging or EEG/ERP/eye tracking acquisition parameters (c) implementation of MRI and EEG/ERP data collection with special populations (individuals with various IDDs, especially infants and children), and (d) management and analysis of MRI and EEG/ERP/eye tracking data. The generative and innovative component of the Translational Neuroscience Core C focuses on key areas that are of particular interest for IDD researchers: design of novel experimental paradigms optimized for IDDs, expanding trans-species imaging capabilities, implementing and augmenting novel data acquisition and analysis methods for measuring neural biomarkers of IDD, developing robust image processing techniques to handle challenging data (e.g., movement artifacts), and providing tools to enable optimal establishment, usage, and analysis of ‘big data’ repositories such as ImageVU. While expertise and resources in neuroimaging, advanced computing, and data management tools are available at Vanderbilt University, none are tailored for the special needs of those who study IDDs. The Aims and services in Core C all have the central goal: facilitate cost-efficient discovery that leads to the prevention and/or amelioration of IDD. Each member of the Core has strong ties to the larger Vanderbilt community, thus enabling seamless linkages between entities at Vanderbilt that are critical for the Core. The Core will serve 22 funded IDD research-related projects.

翻译神经科学核心将：1)为IDDRC调查人员提供设施和服务，以支持 他们在智力和心理领域的个人人类神经成像和心理生理学研究计划 发育性残疾(IDD)；2)继续开发跨物种获取神经成像和 对患有IDD和IDD小鼠模型的人进行心理生理测量；3)利用大数据存储库 在Vanderbilt为IDD开发新工具和发现；4)促进以下领域的跨学科合作 IDDRC调查人员可能具有或可能没有神经成像专业知识；以及5)确保服务 提供的是及时、最高质量和高性价比的。翻译神经科学核心C将支持 上述领域的P50使用者进行磁共振(MR)神经成像和心理生理学检查 措施。核心的服务可以大致理解为两个不同的类别：(1) 响应研究人员的需求；(2)具有创造性并为缺铁性疾病提供新方向的项目 以供调查人员利用。根据调查员需要提供的服务包括(A)试验性援助 设计，包括为磁共振成像(MRI)或脑电选择合适的任务 (B)确定最佳磁共振成像方式或 EEG/ERP/眼球跟踪采集参数(C)实施MRI和EEG/ERP数据收集 特殊人群(患有各种IDDS的个人，特别是婴儿和儿童)，以及(D)管理和 分析MRI和EEG/ERP/眼球跟踪数据。产生和创新的组成部分 翻译神经科学核心C专注于IDD研究人员特别感兴趣的关键领域： 设计针对IDDS进行优化的新实验范例，扩展跨物种成像能力； 实施和加强新的数据采集和分析方法，以测量神经生物标志物 IDD，开发稳健的图像处理技术以处理具有挑战性的数据(例如，运动伪影)， 并提供工具以实现最佳的大数据存储库的建立、使用和分析，例如 ImageVU。虽然在神经成像、高级计算和数据管理工具方面的专业知识和资源 范德比尔特大学提供，但没有一个是为研究IDDS的人的特殊需求量身定做的。 核心C中的目标和服务都有一个中心目标：促进经济高效的发现，从而实现 预防和/或改善碘缺乏病。核心的每个成员都与更大的范德比尔特有很强的联系 因此，范德比尔特的实体之间实现了无缝联系，这对核心是至关重要的。这个 CORE将为22个与IDD研究相关的资助项目提供服务。