Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 10416003
• 负责人: SUE E GARDNER
• 金额: $ 11.86万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416003
• 关键词: Adult; Risk; Science; Symptoms; individualized medicine; multiple chronic conditions

The overall mission of the Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS) is to enhance interdisciplinary, biobehavioral research focused on complex multiple chronic conditions in human adult populations. Its specific purpose is to provide the infrastructure and resources to new investigators and their collaborators integrating two subfields: Multimorbidity Science and Symptom Science, characterizing risk susceptibility and treatment responder profiles using advanced analytic techniques. This will allow clinicians and scientists to identify persons who are more likely to develop specific conditions/symptoms as well as those who may respond to customized therapies. The specific aims of this Center are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. The Center includes 61 faculty and builds upon the research strengths of the faculty at the University of Iowa in symptom science and gerontological nursing (FY2018 research base is $1,118,436 in direct costs). In addition, it is embedded in a strong supportive interdisciplinary network of investigators and Centers from other University departments and Colleges. We will leverage exceptional University resources and complete proposed projects and activities to further the integrated hybrid area of Multimorbidity and Symptom Science. The Center aligns with three thematic areas of the 2016 NINR Strategic Plan: Symptom Science, Self-Management, End-of-Life and Palliative Care and supports the NINR Common Data Element (CDE) initiative.

推进多发病科学中心的总体任务：分析风险和 症状表达为患有多种慢性病的成年人开发个性化治疗方法 (CAMS)是加强跨学科的、专注于复杂多发性慢性疾病的生物行为研究 人类成年人口的状况。 它的具体目的是为新的调查人员和他们的 合作者整合了两个子领域：多发病科学和症状科学，表征风险 使用高级分析技术的敏感度和治疗应答者档案。这将允许 临床医生和科学家以确定哪些人更有可能出现特定情况/症状 以及那些可能对定制疗法有反应的人。该中心的具体目标是： 1.通过建立和建立可持续的跨学科生物行为研究能力 协调基础设施和资源，以促进多发病和 通过开发患者风险和治疗应答者档案的症状科学。 2.从对多重慢性病科学的重新概念化入手，建设主题科学 条件(多发病)包括症状科学。 3.支持将发展为新的科学计划和独立调查人员的研究 研究应用。 该中心包括61名教职员工，建立在加州大学教职员工的研究实力基础上 爱荷华州的症状科学和老年护理(2018财年研究基础为1,118,436美元 成本)。此外，它还嵌入了一个强有力的支持跨学科的调查人员网络和 来自其他大学院系和学院的中心。我们将利用卓越的大学 提供资源并完成拟议的项目和活动，以进一步推动综合混合领域 多病与症状科学。该中心与2016年NINR的三个主题领域保持一致 战略计划：症状科学、自我管理、临终关怀和姑息护理，并支持 NINR通用数据元素(CDE)倡议。