Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 10416002
• 负责人: SUE E GARDNER
• 金额: $ 36.34万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416002
• 关键词: Academy; Address; Adult; Algorithms; Area; Characteristics; Clinical; Common Data Element; Complex; Computer Models; Coupled; Custom; Data Analytics; Development; Diagnosis; Direct Costs; Discipline of Nursing; Disease; Faculty; Funding; Geriatric Nursing; Health; Healthcare; Hybrids; Individual; Infrastructure; Intervention; Iowa; Knowledge; Life Style; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; National Research Council; Outcome; Palliative Care; Patient risk; Patients; Persons; Pilot Projects; Population; Precision Health; Predisposition; Prevalence; Prevention; Preventive; Research; Research Design; Research Personnel; Resources; Risk; Science; Scientist; Self Management; Signs and Symptoms; Strategic Planning; Subgroup; Symptoms; Taxonomy; Techniques; Therapeutic Intervention; Training; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; United States National Library of Medicine; Universities; University resources; Work; advanced analytics; advanced system; base; biobehavior; clinical decision-making; clinical practice; college; contextual factors; cost; disease classification; end of life; genetic makeup; individualized medicine; lens; multiple chronic conditions; precision medicine; preference; preventive intervention; programs; skills; symptom cluster; symptom science; targeted treatment; treatment responders

The overall mission of the Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS) is to enhance interdisciplinary, biobehavioral research focused on complex multiple chronic conditions in human adult populations. Its specific purpose is to provide the infrastructure and resources to new investigators and their collaborators integrating two subfields: Multimorbidity Science and Symptom Science, characterizing risk susceptibility and treatment responder profiles using advanced analytic techniques. This will allow clinicians and scientists to identify persons who are more likely to develop specific conditions/symptoms as well as those who may respond to customized therapies. The specific aims of this Center are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. The Center includes 61 faculty and builds upon the research strengths of the faculty at the University of Iowa in symptom science and gerontological nursing (FY2018 research base is $1,118,436 in direct costs). In addition, it is embedded in a strong supportive interdisciplinary network of investigators and Centers from other University departments and Colleges. We will leverage exceptional University resources and complete proposed projects and activities to further the integrated hybrid area of Multimorbidity and Symptom Science. The Center aligns with three thematic areas of the 2016 NINR Strategic Plan: Symptom Science, Self-Management, End-of-Life and Palliative Care and supports the NINR Common Data Element (CDE) initiative.

推进多形态科学中心的总体使命是： 症状表达，为患有多种慢性疾病的成年人开发定制疗法 （CAMS）是加强跨学科，生物行为研究，重点是复杂的多个慢性 成年人的条件。 其具体目的是为新的调查人员及其工作提供基础设施和资源。 合作者整合两个子领域：多形态科学和症状科学，表征风险 敏感性和治疗应答者概况。这将允许 临床医生和科学家，以确定谁更有可能发展特定的条件/症状的人 以及那些可能对定制疗法有反应的人。该中心的具体目标是： 1.发展可持续的跨学科生物行为研究能力， 协调基础设施和资源，促进多部门一体化， 症状科学通过患者风险和治疗反应概况的发展。 2.建立主题科学，首先是对多重慢性病的科学进行重新概念化 包括症状科学的条件（多发病）。 3.使研究能够发展成为新的科学计划和独立调查员 研究应用。 该中心包括61名教师，并建立在大学教师的研究优势之上。 爱荷华州症状科学和老年护理（2018财年研究基地直接投资1，118，436美元 费用）。此外，它还嵌入了一个强有力的支持性跨学科调查员网络， 其他大学部门和学院的中心。我们将利用卓越的大学 资源和完成拟议的项目和活动，以进一步推动综合混合领域 多发病和症状科学。该中心与2016年NINR的三个主题领域保持一致 战略计划：症状科学，自我管理，生命终结和姑息治疗，并支持 NINR通用数据元素（CDE）计划。

项目成果

Circadian timing, melatonin and hippocampal volume in later-life adults.

晚年成年人的昼夜节律、褪黑激素和海马体积。

• DOI: 10.1111/jsr.14090
• 发表时间: 2023
• 期刊: Journal of sleep research
• 影响因子: 4.4
• 作者: Moon,Chooza;Hoth,KarinF;Perkhounkova,Yelena;Zhang,Meina;Lee,Jihye;Hein,Maria;Hopkins,Lauren;Magnotta,Vincent;Burgess,HelenJ
• 通讯作者: Burgess,HelenJ

An integrated model of multimorbidity and symptom science.

多发病和症状科学的综合模型。

• DOI: 10.1016/j.outlook.2020.03.003
• 发表时间: 2020
• 期刊: Nursing outlook
• 影响因子: 4.3
• 作者: Tripp-Reimer,Toni;Williams,JanetK;Gardner,SueE;Rakel,Barbara;Herr,Keela;McCarthy,AnnMarie;Hand,LindaLiu;Gilbertson-White,Stephanie;Cherwin,Catherine
• 通讯作者: Cherwin,Catherine

One-day Acceptance and Commitment Therapy workshop for preventing persistent post-surgical pain and dysfunction in at-risk veterans: A randomized controlled trial protocol.

• DOI: 10.1016/j.jpsychores.2020.110250
• 发表时间: 2020-11
• 期刊: Journal of psychosomatic research
• 影响因子: 4.7
• 作者: Roddy MK;Boykin DM;Hadlandsmyth K;Marchman JN;Green DM;Buckwalter JA 4th;Garvin L;Zimmerman B;Bae J;Cortesi J;Rodrigues M;Embree J;Rakel BA;Dindo L
• 通讯作者: Dindo L