Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS)

促进多发病科学中心：分析风险和症状表达，为患有多种慢性病的成人开发定制疗法 (CAMS)

• 批准号: 9762982
• 负责人: SUE E GARDNER
• 金额: $ 37.51万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762982
• 关键词: Academy; Address; Adult; Algorithms; Area; Characteristics; Clinical; Common Data Element; Complex; Computer Simulation; Coupled; Custom; Data Analytics; Development; Diagnosis; Direct Costs; Discipline of Nursing; Disease; Faculty; Funding; Geriatric Nursing; Health; Healthcare; Hybrids; Individual; Infrastructure; Intervention; Iowa; Knowledge; Life Style; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; National Research Council; Outcome; Palliative Care; Patient risk; Patients; Persons; Pilot Projects; Population; Precision Health; Predisposition; Prevalence; Prevention; Preventive; Preventive Intervention; Research; Research Design; Research Personnel; Resources; Risk; Science; Scientist; Self Management; Signs and Symptoms; Strategic Planning; Subgroup; Symptoms; System; Taxonomy; Techniques; Therapeutic Intervention; Training; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; United States National Library of Medicine; Universities; University resources; Work; base; biobehavior; clinical decision-making; clinical practice; college; contextual factors; cost; disease classification; end of life; genetic makeup; individualized medicine; lens; multiple chronic conditions; precision medicine; preference; programs; skills; symptom cluster; symptom science; targeted treatment; treatment responders

The overall mission of the Center for Advancing Multimorbidity Science: Profiling risk and symptom expression to develop customized therapies for adults with multiple chronic conditions (CAMS) is to enhance interdisciplinary, biobehavioral research focused on complex multiple chronic conditions in human adult populations. Its specific purpose is to provide the infrastructure and resources to new investigators and their collaborators integrating two subfields: Multimorbidity Science and Symptom Science, characterizing risk susceptibility and treatment responder profiles using advanced analytic techniques. This will allow clinicians and scientists to identify persons who are more likely to develop specific conditions/symptoms as well as those who may respond to customized therapies. The specific aims of this Center are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. The Center includes 61 faculty and builds upon the research strengths of the faculty at the University of Iowa in symptom science and gerontological nursing (FY2018 research base is $1,118,436 in direct costs). In addition, it is embedded in a strong supportive interdisciplinary network of investigators and Centers from other University departments and Colleges. We will leverage exceptional University resources and complete proposed projects and activities to further the integrated hybrid area of Multimorbidity and Symptom Science. The Center aligns with three thematic areas of the 2016 NINR Strategic Plan: Symptom Science, Self-Management, End-of-Life and Palliative Care and supports the NINR Common Data Element (CDE) initiative.

推进多病科学中心的总体使命：分析风险和