Exploratory Center of Excellence for Advancing Multimorbidity Science (CAMS)

促进多种疾病科学卓越探索中心 (CAMS)

• 批准号: 10121495
• 负责人: SUE E GARDNER
• 金额: $ 37.47万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121495
• 关键词: Address; Adherence; Administrative Supplement; Adult; Affect; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; American; Attention; Big Data; Caregivers; Caring; Chronic; Chronic Disease; Clinical; Clinical Practice Guideline; Clinics and Hospitals; Code; Cognition; Communication; Data; Data Set; Dementia; Development; Diagnosis; Disease; Disease Management; Drug Interactions; Elderly; Electronic Health Record; Emergency department visit; Equilibrium; Equipment and supply inventories; Ethnic Origin; Family Caregiver; Frequencies; Funding; Goals; Guidelines; Health; Health Care Costs; Healthcare; High Prevalence; Hospitalization; Individual; Infrastructure; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Intervention; Iowa; Knowledge; Lead; Literature; Measures; Mental Depression; Modeling; Outcome; Pain; Pain Measurement; Pain management; Pain quality; Parents; Patient risk; Patient-Focused Outcomes; Patients; Pattern; Pharmaceutical Preparations; Policies; Polypharmacy; Population; Provider; Quality of life; Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Science; Subgroup; Symptoms; Techniques; Testing; Treatment outcome; Universities; advanced analytics; base; big-data science; biobehavior; care outcomes; care providers; clinical development; clinically relevant; experience; health care service utilization; improved; individualized medicine; medical specialties; mortality; multiple chronic conditions; parent grant; patient health information; patient subsets; profiles in patients; programs; psychological distress; response; sex; side effect; symptom science; treatment responders

Project Summary/Abstract – Parent Study The parent study to this application is the Center for Advancing Multimorbidity Science (CAMS, P20 NR018081-01, PI: Gardner and Rakel). Many people with chronic disease have more than one chronic condition, which is referred to as multimorbidity (multiple chronic conditions: MCC). Patients with MCC have worse health outcomes, including decreased functioning and quality of life as well as greater depression, psychological distress, and mortality. However, little data exist on MCCs risk and treatment profiles to provide direction for clinical practice guidelines development. The specific aims of the parent study are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. Project Summary/Abstract – Administrative Supplement There is very little in the literature on MCC patterns and their associated pain symptomology for patients with Alzheimer’s disease (AD). This supplemental study will investigate relationships among MCC, pain symptomology, healthcare utilization, and AD. We will leverage big data in a healthcare dataset to describe the most clinically relevant MCC patterns in patients with AD and to characterize the pain symptomology and healthcare utilization. The aims of this study are: 1. Identify and describe the most frequent, highly correlated, and clinically relevant patterns of co-occurring chronic conditions among AD patients. 2. Characterize healthcare utilization and pain symptomology for the MCC patient subgroups identified in Aim 1 and compare among the subgroups. 3. Investigate the relationships between healthcare utilization and pain symptomology and MCC subgroups. The results of this study will inform the prioritization of future research leading to clinical guidelines based on patient profiles that will optimize pain treatments and outcomes for patients with AD and MCC.

项目总结/摘要-母研究 该申请的母公司研究是推进多形态科学中心（CAMS， P20 NR 018081 -01，PI：Gardner和Rakel）。许多患有慢性病的人 一种慢性疾病，称为多发病（多种慢性疾病： MCC）。MCC患者的健康状况更差，包括功能下降， 生活质量以及更大的抑郁、心理困扰和死亡率。不过小 存在关于MCC风险和治疗概况的数据，为临床实践指南提供指导 发展母研究的具体目的是： 1.发展可持续的跨学科生物行为研究能力，建立 并协调基础设施和资源，以促进 通过患者风险的发展， 治疗应答者特征。 2.建立主题科学，从多元科学的重新概念化开始 慢性疾病（多发病），包括症状科学。 3.使研究能够发展成为新的科学和独立的项目 调查员研究应用。 项目概要/摘要-行政补充 关于MCC模式及其相关疼痛病理学的文献很少， 阿尔茨海默病（AD）患者。本补充研究将调查 在MCC、疼痛病理学、医疗保健利用和AD中。我们将利用大数据， 医疗保健数据集，以描述AD患者中最具临床相关性的MCC模式， 以表征疼痛病理学和医疗保健利用。本研究的目的是： 1.识别并描述最常见、高度相关和临床相关的模式 在AD患者中同时发生的慢性疾病。 2.描述MCC患者的医疗保健利用和疼痛病理学特征 目标1中确定的亚组，并在亚组之间进行比较。 3.调查医疗保健利用与疼痛病理学之间的关系， MCC分组。 这项研究的结果将为未来的临床研究提供优先考虑。 基于患者资料的指南，将优化患者的疼痛治疗和结局 AD和MCC。