Exploratory Center of Excellence for Advancing Multimorbidity Science (CAMS)

促进多种疾病科学卓越探索中心 (CAMS)

• 批准号: 10121495
• 负责人: SUE E GARDNER
• 金额: $ 37.47万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121495
• 关键词: Address; Adherence; Administrative Supplement; Adult; Affect; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease patient; American; Attention; Big Data; Caregivers; Caring; Chronic; Chronic Disease; Clinical; Clinical Practice Guideline; Clinics and Hospitals; Code; Cognition; Communication; Data; Data Set; Dementia; Development; Diagnosis; Disease; Disease Management; Drug Interactions; Elderly; Electronic Health Record; Emergency department visit; Equilibrium; Equipment and supply inventories; Ethnic Origin; Family Caregiver; Frequencies; Funding; Goals; Guidelines; Health; Health Care Costs; Healthcare; High Prevalence; Hospitalization; Individual; Infrastructure; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Intervention; Iowa; Knowledge; Lead; Literature; Measures; Mental Depression; Modeling; Outcome; Pain; Pain Measurement; Pain management; Pain quality; Parents; Patient risk; Patient-Focused Outcomes; Patients; Pattern; Pharmaceutical Preparations; Policies; Polypharmacy; Population; Provider; Quality of life; Race; Research; Research Personnel; Research Project Grants; Resources; Risk; Science; Subgroup; Symptoms; Techniques; Testing; Treatment outcome; Universities; advanced analytics; base; big-data science; biobehavior; care outcomes; care providers; clinical development; clinically relevant; experience; health care service utilization; improved; individualized medicine; medical specialties; mortality; multiple chronic conditions; parent grant; patient health information; patient subsets; profiles in patients; programs; psychological distress; response; sex; side effect; symptom science; treatment responders

Project Summary/Abstract – Parent Study The parent study to this application is the Center for Advancing Multimorbidity Science (CAMS, P20 NR018081-01, PI: Gardner and Rakel). Many people with chronic disease have more than one chronic condition, which is referred to as multimorbidity (multiple chronic conditions: MCC). Patients with MCC have worse health outcomes, including decreased functioning and quality of life as well as greater depression, psychological distress, and mortality. However, little data exist on MCCs risk and treatment profiles to provide direction for clinical practice guidelines development. The specific aims of the parent study are to: 1. Develop a sustainable interdisciplinary biobehavioral research capacity by establishing and coordinating an infrastructure and resources that facilitates the integration of Multimorbidity and Symptom Science through the development of patient risk and therapy responder profiles. 2. Build thematic science beginning with a reconceptualization of the science of Multiple Chronic Conditions (Multimorbidity) to include Symptom Science. 3. Enable research that will develop into new programs of science and independent investigator research applications. Project Summary/Abstract – Administrative Supplement There is very little in the literature on MCC patterns and their associated pain symptomology for patients with Alzheimer’s disease (AD). This supplemental study will investigate relationships among MCC, pain symptomology, healthcare utilization, and AD. We will leverage big data in a healthcare dataset to describe the most clinically relevant MCC patterns in patients with AD and to characterize the pain symptomology and healthcare utilization. The aims of this study are: 1. Identify and describe the most frequent, highly correlated, and clinically relevant patterns of co-occurring chronic conditions among AD patients. 2. Characterize healthcare utilization and pain symptomology for the MCC patient subgroups identified in Aim 1 and compare among the subgroups. 3. Investigate the relationships between healthcare utilization and pain symptomology and MCC subgroups. The results of this study will inform the prioritization of future research leading to clinical guidelines based on patient profiles that will optimize pain treatments and outcomes for patients with AD and MCC.

项目摘要/摘要-家长研究 这一应用的母研究是先进多病科学中心(CAMS， P20 NR018081-01，PI：Gardner和Rakel)。许多患有慢性病的人有超过 一种慢性疾病，称为多发病(多种慢性疾病： MCC)。MCC患者的健康结局更差，包括功能下降和 生活质量以及更严重的抑郁、心理痛苦和死亡率。然而，几乎没有 有关于MCC风险和治疗概况的数据，为临床实践指南提供指导 发展。家长研究的具体目标是： 1.通过建立可持续的跨学科生物行为研究能力 以及协调基础设施和资源，以促进 通过患者风险和发展的多病和症状科学 治疗应答者档案。 2.从对多元科学的重新概念化开始，建立主题科学 慢性病(多发病)包括症状科学。 3.使研究发展成为新的科学和独立的项目 调查员研究应用。 项目摘要/摘要-行政副刊 关于微循环模式及其相关的疼痛症状的文献很少。 阿尔茨海默病(AD)患者。这项补充研究将调查人际关系 在MCC、疼痛症状、医疗保健利用和AD中。我们将在 医疗保健数据集，以描述AD患者最具临床相关性的MCC模式 描述疼痛症状和医疗保健利用情况。这项研究的目的是： 1.识别和描述最常见、高度相关和临床相关的模式 阿尔茨海默病患者的慢性病并存情况。 2.描述MCC患者的医疗利用情况和疼痛症状 目标1中确定的子组，并在子组之间进行比较。 3.调查医疗服务利用与疼痛症状及 MCC亚群。 这项研究的结果将为未来导致临床研究的优先顺序提供信息 基于患者概况的指南，将优化患者的疼痛治疗和结果 AD和MCC。