Studies on Antimicrobial resistance in bacteria of veterinary importance

具有兽医重要性的细菌的耐药性研究

• 批准号: 10415863
• 负责人: CRAIG ALTIER
• 金额: $ 6.17万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415863
• 关键词: Studies; Antimicrobial; resistance; bacteria; veterinary

Project Summary/Abstract The New York State/Cornell Animal Health Diagnostic Center (AHDC) is a full-service multidisciplinary veterinary diagnostic laboratory and the only one of its kind in the northeastern United States. The AHDC received over 200,000 client accessions in 2016. The Bacteriology section has MALDI-TOF, Sensititer, Blood culture machine, BSL3 upgradable workspace and 16S DNA sequencing capabilities, making it a full-service bacteriology laboratory. Additionally, the AHDC has in-house ISO approved Whole genome sequencing capacity which are unique to infectious disease laboratories. The Bacteriology laboratory of the AHDC performed approximately 100,000 tests in the year 2016 on clinical samples, tissue, serum, bacterial isolates, environmental, food, and feed samples. The AHDC has partnered with the FDA and played an active role in pet food and animal feed contamination investigations many times over the past dozen years. We hope to continue our participation with the FDA Vet-LIRN program and other network laboratories to: 1) Continue participation in VPO designated sample analyses and surveillance activities to promote animal health and welfare and add to the Vet-LIRN Network's surge capacity to assist in emergency and large-scale outbreak testing. 2) Provide analytical data to support regulatory actions by developing and using standardized methods, equipment platforms, and reporting methods, continued participation in proficiency testing provided by the VPO, continue investigating consumer reported cases as requested by the VPO, and continuing to improve and implement standardized quality management systems as designated by the VPO. 3) Continue to participate in small-scale antibiotic susceptibility testing studies to address emerging antimicrobial resistance issues, and participate in Whole genome sequencing project. The bacteriology section of the AHDC intends to continue cooperative activities with the FDA Vet-LIRN, the Vet- LIRN network, and federal, state, local and tribal organizations to promote animal health and feed and food safety and security.

项目总结/文摘

项目成果

Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring.

基因组学可准确预​​测作为 Vet-LIRN 耐药性监测的一部分收集的伪中间葡萄球菌中的抗菌药物耐药性。

• DOI: 10.1016/j.vetmic.2021.109006
• 发表时间: 2021
• 期刊: Veterinary microbiology
• 影响因子: 3.3
• 作者: Tyson,GregoryH;Ceric,Olgica;Guag,Jake;Nemser,Sarah;Borenstein,Stacey;Slavic,Durda;Lippert,Sarah;McDowell,Rebecca;Krishnamurthy,Aparna;Korosec,Shannon;Friday,Cheryl;Pople,Neil;Saab,MatthewE;Fairbrother,Julie-Hélène;Janelle,Is
• 通讯作者: Janelle,Is

Patterns of antimicrobial drug use in veterinary primary care and specialty practice: A 6-year multi-institution study.

• DOI: 10.1111/jvim.16136
• 发表时间: 2021-05
• 期刊: Journal of veterinary internal medicine
• 影响因子: 2.6
• 作者: Goggs R;Menard JM;Altier C;Cummings KJ;Jacob ME;Lalonde-Paul DF;Papich MG;Norman KN;Fajt VR;Scott HM;Lawhon SD
• 通讯作者: Lawhon SD

Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time.

• DOI: 10.1186/s42523-022-00178-9
• 发表时间: 2022-06-04
• 期刊: Animal microbiome
• 影响因子: 4.7

Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.

• DOI: 10.1177/03009858211067467
• 发表时间: 2022-07
• 期刊: Veterinary pathology
• 影响因子: 2.4