Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study
老年人衰老和认知健康评估 (ACHIEVE) 随机研究中听力干预对大脑健康的长期影响
基本信息
- 批准号:10418325
- 负责人:
- 金额:$ 412.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAgeAgingAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskBrainClinicalCognitiveCognitive agingComplementControl GroupsCountyDataDementiaEducationElderlyEvaluationFollow-Up StudiesHealthHealth EducatorsHealth ExpendituresHealthcareHearingHearing AidsHeterogeneityImpaired cognitionInterventionLong-Term EffectsMeasuresMediator of activation proteinMedicalMedicare claimObservational StudyOutcomeParticipantPathologicPathway interactionsPeripheralPhasePoliciesPopulationRandomizedRehabilitation therapyRiskRoleScheduleServicesSeveritiesSiteSocial FunctioningStructureTechnologyTimeTrainingVisitWashingtonbrain healthbrain magnetic resonance imagingbrain volumeclinical carecognitive loadcohortdementia riskfollow-uphealthy aginghearing impairmenthearing loss treatmentmild cognitive impairmentmodifiable risknovel strategiesprimary outcomerandomized trialrecruitsocial engagementsoundtreatment effectwhite matter
项目摘要
Novel approaches to reduce the risk of cognitive decline and Alzheimer's disease and related dementias (ADRD)
in older adults are urgently needed given the aging of the population. Over the past decade, observational
research has implicated peripheral hearing loss as being one of the largest potentially modifiable risk factors for
dementia that may account for 8-9% of all dementia cases. Hypothesized pathways underlying this observed
association may be modifiable with hearing loss treatment consisting of the use of hearing technologies (e.g.,
hearing aids) and rehabilitative training. The Aging & Cognitive Health Evaluation in Elders (ACHIEVE) study is
an ongoing, NIA-sponsored Phase III RCT (R01AG055426, MPIs: Lin/Coresh) investigating whether hearing
loss treatment versus an aging education control intervention reduces cognitive decline over a three-year follow-
up period. From 2018-19, we recruited 977 adults ages 70-84 with untreated mild-to-moderate hearing loss who
were randomized 1:1 at baseline (Year 0) to receive hearing intervention (HI; best-practice hearing services and
technologies) versus a successful aging (SA) education control intervention (i.e., one-on-one sessions with a
health educator covering topics important for healthy aging). Participants are currently being followed
semiannually at the ACHIEVE field sites with final Year 3 study visits scheduled from 2021-22. After their Year 3
visit, all participants randomized to the SA education control group will also be offered the hearing intervention.
Final Year 3 results from this original trial will indicate whether hearing intervention (versus a successful aging
control intervention) reduces cognitive decline over a 3-year interval after randomization. We now propose to
continue following the ACHIEVE cohort for an additional 3 years (i.e., up to Year 6) to determine the long-
term effects of hearing intervention (i.e., participants randomized to HI at Year 0) versus successful
aging/delayed HI control (i.e., participants randomized to SA at Year 0 and offered HI after their Year 3
visit) on cognitive and brain outcomes. Given that cognitive impairment typically reflects the slow
accumulation of pathologic changes, the benefits of HI in slowing this decline may not be fully appreciable within
just 3 years. Therefore, this 6-year follow-up of the cohort will allow us to fully evaluate the longer, cumulative
impact of HI on older adults. Such findings will complement the main trial results in 2023 and directly inform
clinical and policy decisions around the potential use of hearing interventions to reduce the risk of ADRD. This
proposed study has the following aims: Aim 1 To determine the long-term effect of HI versus SA/Delayed HI
control on rates of the co-primary outcomes of: (a) cognitive decline and (b) incident mild cognitive impairment
(MCI)/dementia. Aim 2 To determine the long-term effect of HI versus SA/Delayed HI control on changes in
brain MRI measures of: (a) regional brain volumes and (b) white matter tract integrity. Secondary Aims: 1) To
investigate potential factors contributing to HI treatment effect heterogeneity; 2) To investigate health care
expenditures and utilization between the HI vs SA/Delayed HI control groups by analyzing Medicare claims data.
降低认知能力下降和阿尔茨海默病及相关痴呆(ADRD)风险的新方法
项目成果
期刊论文数量(0)
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JOSEF CORESH其他文献
JOSEF CORESH的其他文献
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{{ truncateString('JOSEF CORESH', 18)}}的其他基金
Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study
老年人衰老和认知健康评估 (ACHIEVE) 随机研究中听力干预对大脑健康的长期影响
- 批准号:
10680434 - 财政年份:2022
- 资助金额:
$ 412.39万 - 项目类别:
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
- 批准号:
10788250 - 财政年份:2021
- 资助金额:
$ 412.39万 - 项目类别:
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
- 批准号:
10620984 - 财政年份:2021
- 资助金额:
$ 412.39万 - 项目类别:
Integrative Omics, Chronic Kidney Disease, and Adverse Outcomes in Older Adults
综合组学、慢性肾病和老年人的不良后果
- 批准号:
10163839 - 财政年份:2020
- 资助金额:
$ 412.39万 - 项目类别:
Integrative Omics, Chronic Kidney Disease, and Adverse Outcomes in Older Adults
综合组学、慢性肾病和老年人的不良后果
- 批准号:
10368118 - 财政年份:2020
- 资助金额:
$ 412.39万 - 项目类别:
ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT
ARIC - JHU 野外中心 - 多样性补充
- 批准号:
10054600 - 财政年份:2019
- 资助金额:
$ 412.39万 - 项目类别:
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial
老年人的衰老、认知和听力评估 (ACHIEVE) 随机试验
- 批准号:
9986336 - 财政年份:2017
- 资助金额:
$ 412.39万 - 项目类别:
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial
老年人的衰老、认知和听力评估 (ACHIEVE) 随机试验
- 批准号:
9287053 - 财政年份:2017
- 资助金额:
$ 412.39万 - 项目类别:
IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS
IGF::OT::IGF 动脉粥样硬化风险社区 - 现场中心 - 核心研究操作
- 批准号:
10329837 - 财政年份:2016
- 资助金额:
$ 412.39万 - 项目类别:
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