Resource Development Core
资源开发核心
基本信息
- 批准号:10747706
- 负责人:
- 金额:$ 28.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAreaBasic ScienceBiological FactorsBloodBrainCalibrationClinicalClinical ResearchClinical SciencesCollaborationsCommunitiesDevelopmentDisparityDoctor of PhilosophyEnsureEpidemiologyEquationEquityFinancial HardshipFirst Independent Research Support and Transition AwardsFoundationsGoalsHealthHumanIncubatorsInstitutionInvestmentsKidneyMaintenanceMediatingModelingMusPhysiologyPoliciesProteomicsPublic HealthRenal functionResearchResearch PersonnelResource DevelopmentResourcesRiskRoleSamplingScientistSex DifferencesSystemTechnologyTestingTissuesUrineWorkadverse outcomebiomedical resourceblood pressure regulationdata resourcedesigngut microbiotahealth equityhealth inequalitiesinnovationinterestmeetingsmid-career facultymouse modelnovelpopulation healthprofessorsocial health determinantssocial metricssocial stressortool
项目摘要
RESOURCE DEVELOPMENT CORE
ABSTRACT
Kidney health equity is a growing area of research interest in the scientific community, and new resources are
needed to ensure this work harnesses the full spectrum of research (basic, clinical, and translational) with
excellence and rigor. The Resource Development Core (RDC; Co-Directors: Joe Coresh, MD, PhD and Jen
Pluznick, PhD) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will develop new and
refine existing resources for the conduct of basic and clinical research relevant to kidney health equity. Mature
resources will be transferred to the Biomedical Resource Core (BRC) and shared with the broader scientific
community. We will work to anticipate the needs of the research community so that we appropriately prioritize
investments and will continuously develop new ideas at Johns Hopkins as part of a dynamic incubator space
connected to national needs. The RDC will validate all new resources and share them with the BRC for
maintenance and local and national dissemination. We will leverage the strength of Johns Hopkins in kidney
health equity which spans from basic science to clinical science to epidemiology, to advance two Aims. In Aim
1, we will develop new clinical science resources to advance kidney health equity. In this aim, we will build on
a strong foundation in this area in order to innovate and build new resources including metrics of social
determinants of health designed to generate momentum towards equity, validating and interpreting proteomic
findings, and including and calibrating risk equations to social determinants of health. In Aim 2, we will
develop new basic science resources which uncover mechanisms underpinning kidney health inequity. In
Year 1, our basic science efforts will focus on establishing two key resources for the research community
focused on brain-kidney crosstalk during social stressors, and gut microbiota and sex differences. We will
work to not only make mouse models widely available through the BRC, but critically, will also develop Sample
Banks (including tissues, blood, and urine) through which researchers can easily explore these models with
minimal logistical and financial burden. In Years 2-5, we will establish new models addressing kidney health
equity and likewise transfer to the BRC both mice and Sample Banks. Together, the two Aims of this proposal
will provide new resources to propel forward research addressing kidney health equity.
资源开发核心
抽象的
肾脏健康公平性是科学界日益关注的研究领域,新的资源正在不断涌现
需要确保这项工作利用全方位的研究(基础、临床和转化)
卓越和严谨。资源开发核心(RDC;联合主任:Joe Coresh,医学博士、哲学博士和 Jen
约翰·霍普金斯大学奥布莱恩促进肾脏健康公平中心的 Pluznick 博士)将开发新的和
完善现有资源,开展与肾脏健康公平相关的基础和临床研究。成熟
资源将转移到生物医学资源核心(BRC)并与更广泛的科学领域共享
社区。我们将努力预测研究界的需求,以便我们适当地确定优先顺序
投资并将在约翰·霍普金斯大学不断开发新想法,作为动态孵化器空间的一部分
与国家需求相结合。 RDC 将验证所有新资源并与 BRC 共享
维护以及地方和全国传播。我们将利用约翰霍普金斯大学在肾脏领域的优势
健康公平涵盖从基础科学到临床科学再到流行病学,以推进两个目标。瞄准
1、我们将开发新的临床科学资源,以促进肾脏健康公平。为了这个目标,我们将在此基础上
在该领域奠定坚实的基础,以便创新和建立新的资源,包括社会指标
健康的决定因素旨在产生公平的动力,验证和解释蛋白质组学
研究结果,并根据健康的社会决定因素纳入和校准风险方程。在目标 2 中,我们将
开发新的基础科学资源,揭示肾脏健康不平等的机制。在
第一年,我们的基础科学工作将集中于为研究界建立两个关键资源
重点关注社会压力下的脑肾交互作用,以及肠道微生物群和性别差异。我们将
不仅致力于通过 BRC 广泛提供小鼠模型,而且至关重要的是,还将开发样品
研究人员可以通过银行(包括组织、血液和尿液)轻松探索这些模型
最小的后勤和财务负担。在第 2-5 年,我们将建立解决肾脏健康问题的新模型
股权并同样将小鼠和样本银行转移到 BRC。该提案的两个目标
将提供新的资源来推动解决肾脏健康公平问题的研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEF CORESH其他文献
JOSEF CORESH的其他文献
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{{ truncateString('JOSEF CORESH', 18)}}的其他基金
Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study
老年人衰老和认知健康评估 (ACHIEVE) 随机研究中听力干预对大脑健康的长期影响
- 批准号:
10680434 - 财政年份:2022
- 资助金额:
$ 28.59万 - 项目类别:
Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study
老年人衰老和认知健康评估 (ACHIEVE) 随机研究中听力干预对大脑健康的长期影响
- 批准号:
10418325 - 财政年份:2022
- 资助金额:
$ 28.59万 - 项目类别:
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
- 批准号:
10788250 - 财政年份:2021
- 资助金额:
$ 28.59万 - 项目类别:
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
- 批准号:
10620984 - 财政年份:2021
- 资助金额:
$ 28.59万 - 项目类别:
Integrative Omics, Chronic Kidney Disease, and Adverse Outcomes in Older Adults
综合组学、慢性肾病和老年人的不良后果
- 批准号:
10163839 - 财政年份:2020
- 资助金额:
$ 28.59万 - 项目类别:
Integrative Omics, Chronic Kidney Disease, and Adverse Outcomes in Older Adults
综合组学、慢性肾病和老年人的不良后果
- 批准号:
10368118 - 财政年份:2020
- 资助金额:
$ 28.59万 - 项目类别:
ARIC - JHU FIELD CENTER - DIVERSITY SUPPLEMENT
ARIC - JHU 野外中心 - 多样性补充
- 批准号:
10054600 - 财政年份:2019
- 资助金额:
$ 28.59万 - 项目类别:
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial
老年人的衰老、认知和听力评估 (ACHIEVE) 随机试验
- 批准号:
9986336 - 财政年份:2017
- 资助金额:
$ 28.59万 - 项目类别:
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized Trial
老年人的衰老、认知和听力评估 (ACHIEVE) 随机试验
- 批准号:
9287053 - 财政年份:2017
- 资助金额:
$ 28.59万 - 项目类别:
IGF::OT::IGF ATHEROSCLEROSIS IN RISK COMMUNITIES - FIELD CENTER - CORE STUDY OPERATIONS
IGF::OT::IGF 动脉粥样硬化风险社区 - 现场中心 - 核心研究操作
- 批准号:
10329837 - 财政年份:2016
- 资助金额:
$ 28.59万 - 项目类别:
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