Resource Development Core

资源开发核心

• 批准号: 10747706
• 负责人: JOSEF CORESH
• 金额: $ 28.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747706
• 关键词: Acceleration; Address; Area; Basic Science; Biological Factors; Blood; Brain; Calibration; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Disparity; Doctor of Philosophy; Ensure; Epidemiology; Equation; Equity; Financial Hardship; First Independent Research Support and Transition Awards; Foundations; Goals; Health; Human; Incubators; Institution; Investments; Kidney; Maintenance; Mediating; Modeling; Mus; Physiology; Policies; Proteomics; Public Health; Renal function; Research; Research Personnel; Resource Development; Resources; Risk; Role; Sampling; Scientist; Sex Differences; System; Technology; Testing; Tissues; Urine; Work; adverse outcome; biomedical resource; blood pressure regulation; data resource; design; gut microbiota; health equity; health inequalities; innovation; interest; meetings; mid-career faculty; mouse model; novel; population health; professor; social health determinants; social metrics; social stressor; tool

RESOURCE DEVELOPMENT CORE ABSTRACT Kidney health equity is a growing area of research interest in the scientific community, and new resources are needed to ensure this work harnesses the full spectrum of research (basic, clinical, and translational) with excellence and rigor. The Resource Development Core (RDC; Co-Directors: Joe Coresh, MD, PhD and Jen Pluznick, PhD) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will develop new and refine existing resources for the conduct of basic and clinical research relevant to kidney health equity. Mature resources will be transferred to the Biomedical Resource Core (BRC) and shared with the broader scientific community. We will work to anticipate the needs of the research community so that we appropriately prioritize investments and will continuously develop new ideas at Johns Hopkins as part of a dynamic incubator space connected to national needs. The RDC will validate all new resources and share them with the BRC for maintenance and local and national dissemination. We will leverage the strength of Johns Hopkins in kidney health equity which spans from basic science to clinical science to epidemiology, to advance two Aims. In Aim 1, we will develop new clinical science resources to advance kidney health equity. In this aim, we will build on a strong foundation in this area in order to innovate and build new resources including metrics of social determinants of health designed to generate momentum towards equity, validating and interpreting proteomic findings, and including and calibrating risk equations to social determinants of health. In Aim 2, we will develop new basic science resources which uncover mechanisms underpinning kidney health inequity. In Year 1, our basic science efforts will focus on establishing two key resources for the research community focused on brain-kidney crosstalk during social stressors, and gut microbiota and sex differences. We will work to not only make mouse models widely available through the BRC, but critically, will also develop Sample Banks (including tissues, blood, and urine) through which researchers can easily explore these models with minimal logistical and financial burden. In Years 2-5, we will establish new models addressing kidney health equity and likewise transfer to the BRC both mice and Sample Banks. Together, the two Aims of this proposal will provide new resources to propel forward research addressing kidney health equity.

资源开发核心 摘要 肾脏健康公平是科学界越来越感兴趣的研究领域，新的资源是 需要确保这项工作利用全方位的研究(基础、临床和翻译) 卓越和严谨。资源开发核心(RDC；联席董事：Joe Coresh，MD，PhD和Jen 约翰霍普金斯大学奥布莱恩中心促进肾脏健康公平的Pluznick博士)将开发新的 完善现有资源，开展与肾脏健康公平相关的基础和临床研究。成熟 资源将被转移到生物医学资源核心(BRC)，并与更广泛的科学 社区。我们将努力预测研究界的需求，以便我们适当地优先考虑 作为动态孵化器空间的一部分，他将在约翰霍普金斯大学不断开发新想法 与国家需求相联系。RDC将验证所有新资源，并与BRC共享这些资源 维护以及在当地和全国范围内传播。我们将利用约翰霍普金斯大学在肾脏方面的优势 健康公平，从基础科学到临床科学再到流行病学，推进两个目标。在AIM 1.开发新的临床科学资源，促进肾脏健康公平。为了实现这一目标，我们将在 在这一领域有坚实的基础，以便创新和建立新的资源，包括社会指标 健康的决定因素，旨在产生朝着公平、验证和解释蛋白质组学的势头 研究结果，并纳入和校准健康的社会决定因素的风险方程。在目标2中，我们将 开发新的基础科学资源，揭示肾脏健康不平等的机制。在……里面 第一年，我们的基础科学工作将集中于为研究界建立两个关键资源 重点研究了社会应激源中的脑-肾串扰，以及肠道微生物区系和性别差异。我们会 努力不仅通过BRC广泛提供鼠标模型，而且至关重要的是，还将开发样本 库(包括组织、血液和尿液)，研究人员可以通过这些库轻松地探索这些模型 将后勤和财政负担降至最低。在第二到第五年，我们将建立新的模型来解决肾脏健康问题 股权，并同样转移给BRC，包括MICE和样本银行。这项提案的两个目标加在一起 将提供新的资源来推动解决肾脏健康公平问题的研究。