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Resource Development Core

资源开发核心

基本信息

批准号：
10747706
负责人：
JOSEF CORESH
金额：
$ 28.59万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747706
关键词：
Acceleration Address Area Basic Science Biological Factors Blood Brain Calibration Clinical Clinical Research Clinical Sciences Collaborations Communities Development Disparity Doctor of Philosophy Ensure Epidemiology Equation Equity Financial Hardship First Independent Research Support and Transition Awards Foundations Goals Health Human Incubators Institution Investments Kidney Maintenance Mediating Modeling Mus Physiology Policies Proteomics Public Health Renal function Research Research Personnel Resource Development Resources Risk Role Sampling Scientist Sex Differences System Technology Testing Tissues Urine Work adverse outcome biomedical resource blood pressure regulation data resource design gut microbiota health equity health inequalities innovation interest meetings mid-career faculty mouse model novel population health professor social health determinants social metrics social stressor tool

项目摘要

RESOURCE DEVELOPMENT CORE ABSTRACT Kidney health equity is a growing area of research interest in the scientific community, and new resources are needed to ensure this work harnesses the full spectrum of research (basic, clinical, and translational) with excellence and rigor. The Resource Development Core (RDC; Co-Directors: Joe Coresh, MD, PhD and Jen Pluznick, PhD) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will develop new and refine existing resources for the conduct of basic and clinical research relevant to kidney health equity. Mature resources will be transferred to the Biomedical Resource Core (BRC) and shared with the broader scientific community. We will work to anticipate the needs of the research community so that we appropriately prioritize investments and will continuously develop new ideas at Johns Hopkins as part of a dynamic incubator space connected to national needs. The RDC will validate all new resources and share them with the BRC for maintenance and local and national dissemination. We will leverage the strength of Johns Hopkins in kidney health equity which spans from basic science to clinical science to epidemiology, to advance two Aims. In Aim 1, we will develop new clinical science resources to advance kidney health equity. In this aim, we will build on a strong foundation in this area in order to innovate and build new resources including metrics of social determinants of health designed to generate momentum towards equity, validating and interpreting proteomic findings, and including and calibrating risk equations to social determinants of health. In Aim 2, we will develop new basic science resources which uncover mechanisms underpinning kidney health inequity. In Year 1, our basic science efforts will focus on establishing two key resources for the research community focused on brain-kidney crosstalk during social stressors, and gut microbiota and sex differences. We will work to not only make mouse models widely available through the BRC, but critically, will also develop Sample Banks (including tissues, blood, and urine) through which researchers can easily explore these models with minimal logistical and financial burden. In Years 2-5, we will establish new models addressing kidney health equity and likewise transfer to the BRC both mice and Sample Banks. Together, the two Aims of this proposal will provide new resources to propel forward research addressing kidney health equity.

资源开发核心抽象的肾脏健康公平性是科学界日益关注的研究领域，新的资源正在不断涌现需要确保这项工作利用全方位的研究（基础、临床和转化）卓越和严谨。资源开发核心（RDC；联合主任：Joe Coresh，医学博士、哲学博士和 Jen 约翰·霍普金斯大学奥布莱恩促进肾脏健康公平中心的 Pluznick 博士）将开发新的和完善现有资源，开展与肾脏健康公平相关的基础和临床研究。成熟资源将转移到生物医学资源核心（BRC）并与更广泛的科学领域共享社区。我们将努力预测研究界的需求，以便我们适当地确定优先顺序投资并将在约翰·霍普金斯大学不断开发新想法，作为动态孵化器空间的一部分与国家需求相结合。 RDC 将验证所有新资源并与 BRC 共享维护以及地方和全国传播。我们将利用约翰霍普金斯大学在肾脏领域的优势健康公平涵盖从基础科学到临床科学再到流行病学，以推进两个目标。瞄准 1、我们将开发新的临床科学资源，以促进肾脏健康公平。为了这个目标，我们将在此基础上在该领域奠定坚实的基础，以便创新和建立新的资源，包括社会指标健康的决定因素旨在产生公平的动力，验证和解释蛋白质组学研究结果，并根据健康的社会决定因素纳入和校准风险方程。在目标 2 中，我们将开发新的基础科学资源，揭示肾脏健康不平等的机制。在第一年，我们的基础科学工作将集中于为研究界建立两个关键资源重点关注社会压力下的脑肾交互作用，以及肠道微生物群和性别差异。我们将不仅致力于通过 BRC 广泛提供小鼠模型，而且至关重要的是，还将开发样品研究人员可以通过银行（包括组织、血液和尿液）轻松探索这些模型最小的后勤和财务负担。在第 2-5 年，我们将建立解决肾脏健康问题的新模型股权并同样将小鼠和样本银行转移到 BRC。该提案的两个目标将提供新的资源来推动解决肾脏健康公平问题的研究。