Resource Development Core

资源开发核心

• 批准号: 10747706
• 负责人: JOSEF CORESH
• 金额: $ 28.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747706
• 关键词: Acceleration; Address; Area; Basic Science; Biological Factors; Blood; Brain; Calibration; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Disparity; Doctor of Philosophy; Ensure; Epidemiology; Equation; Equity; Financial Hardship; First Independent Research Support and Transition Awards; Foundations; Goals; Health; Human; Incubators; Institution; Investments; Kidney; Maintenance; Mediating; Modeling; Mus; Physiology; Policies; Proteomics; Public Health; Renal function; Research; Research Personnel; Resource Development; Resources; Risk; Role; Sampling; Scientist; Sex Differences; System; Technology; Testing; Tissues; Urine; Work; adverse outcome; biomedical resource; blood pressure regulation; data resource; design; gut microbiota; health equity; health inequalities; innovation; interest; meetings; mid-career faculty; mouse model; novel; population health; professor; social health determinants; social metrics; social stressor; tool

RESOURCE DEVELOPMENT CORE ABSTRACT Kidney health equity is a growing area of research interest in the scientific community, and new resources are needed to ensure this work harnesses the full spectrum of research (basic, clinical, and translational) with excellence and rigor. The Resource Development Core (RDC; Co-Directors: Joe Coresh, MD, PhD and Jen Pluznick, PhD) of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity will develop new and refine existing resources for the conduct of basic and clinical research relevant to kidney health equity. Mature resources will be transferred to the Biomedical Resource Core (BRC) and shared with the broader scientific community. We will work to anticipate the needs of the research community so that we appropriately prioritize investments and will continuously develop new ideas at Johns Hopkins as part of a dynamic incubator space connected to national needs. The RDC will validate all new resources and share them with the BRC for maintenance and local and national dissemination. We will leverage the strength of Johns Hopkins in kidney health equity which spans from basic science to clinical science to epidemiology, to advance two Aims. In Aim 1, we will develop new clinical science resources to advance kidney health equity. In this aim, we will build on a strong foundation in this area in order to innovate and build new resources including metrics of social determinants of health designed to generate momentum towards equity, validating and interpreting proteomic findings, and including and calibrating risk equations to social determinants of health. In Aim 2, we will develop new basic science resources which uncover mechanisms underpinning kidney health inequity. In Year 1, our basic science efforts will focus on establishing two key resources for the research community focused on brain-kidney crosstalk during social stressors, and gut microbiota and sex differences. We will work to not only make mouse models widely available through the BRC, but critically, will also develop Sample Banks (including tissues, blood, and urine) through which researchers can easily explore these models with minimal logistical and financial burden. In Years 2-5, we will establish new models addressing kidney health equity and likewise transfer to the BRC both mice and Sample Banks. Together, the two Aims of this proposal will provide new resources to propel forward research addressing kidney health equity.

资源开发核心 抽象的 肾脏健康公平是科学界的研究兴趣的越来越多的领域，而新资源是 确保这项工作需要利用这项工作的全部研究（基本，临床和翻译） 卓越和严格。资源开发核心（RDC；联合导演：Joe Coresh，医学博士，博士和Jen 约翰·霍普金斯·奥布莱恩（John Hopkins O'Brien Center）的Pluznick，Pluznick，Pluznick of Hidney Health公平将发展新的，并且 优化现有资源，以进行与肾脏健康公平有关的基础和临床研究。成熟 资源将被转移到生物医学资源核心（BRC），并与更广泛的科学分享 社区。我们将努力预测研究界的需求，以便我们适当优先考虑 投资，并将继续在约翰·霍普金斯（Johns Hopkins）发展新想法，这是动态孵化器空间的一部分 与国家需求有关。 RDC将验证所有新资源，并与BRC共享 维护以及地方和国家传播。我们将利用约翰·霍普金斯在肾脏中的力量 从基础科学到临床科学再到流行病学的卫生公平，以促进两个目标。 1，我们将开发新的临床科学资源来促进肾脏健康公平。在此目标中，我们将基于 为了创新和建立新资源，包括社会指标 确定旨在为公平产生动力，验证和解释蛋白质组学的健康状况 调查结果以及对健康的社会决定者的风险方程式包括在内。在AIM 2中，我们将 开发新的基础科学资源，发现肾脏健康不平等的机制。在 第1年，我们的基础科学工作将重点放在为研究界建立两个关键资源 在社会压力源以及肠道菌群和性别差异期间，专注于脑部kidney串扰。我们将 工作以使鼠标模型不仅通过BRC广泛使用，而且批判性地将开发样本 银行（包括组织，血液和尿液），研究人员可以通过这些银行可以轻松地探索这些模型 最小的后勤和金融伯恩。在2 - 5年中，我们将建立针对肾脏健康的新模型 股权和同样转移到BRC的小鼠和样本库。共同，该提议的两个目标 将提供新的资源来推动针对肾脏健康公平的远期研究。