Acquisition of an automated phase and fluorescence microscope for Cornell BRC Imaging Facility

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Project Summary/Abstract Though NIH researchers at Cornell University (Ithaca campus) are fortunate to have access to a handful of high-end advanced microscopies (confocal, multiphoton, super resolution, light sheet), they lack a workhorse inverted microscope that is broadly available for experiments requiring low to medium magnification. This proposal describes a request for a Keyence compact microscope with phase contrast and fluorescence capabilities, an automated stage and a stagetop incubator. The microscope supports timelaspe imaging, multi-position imaging, tiling, and imaging in multiwell plates and flasks. It will be managed within the Imaging Facility as part of Cornell’s Biotechnology Resource Center (BRC). Data management, scheduling and billing will be accomplished using already established BRC infrastructure. The microscope will be available to all researchers on and off campus, and will specifically advance NIH-funded research programs focused on tissue development, immunity, cancer, and biophysical signaling and communication.