课题基金 / 基金详情

SIMULTANEOUS 5 HT & PH IMAGING IN PARAFOLLICULAR CELL GRANULES

SIMULTANEOUS 5 HT & PH IMAGING IN PARAFOLLICULAR CELL GRANULES
同时 5 HT
批准号：
6121888
负责人：
REBECCA M WILLIAMS
金额：
$2.24万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6121888
关键词：
animal tissue bioengineering /biomedical engineering biomedical equipment development biomedical resource human tissue immunology inflammation lasers lymphatic system technology /technique

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Paraneurons (parafollicular cells), found in the thyroid gland, are endocrine cells, but developmentally related to neurons and moreover can be readily isolated in a pure form for experimental analysis. Serotoninergic neurons cannot similarly be isolated. Work on this cell preparation has revealed that the secretion competent granule interiors experience transient pH drops after cell stimulation. Chloride channels that are regulated by protein kinases C and G are implicated. We are simultaneously imaging 5-HT and a granule pH marker to investigate proposed correlations between 5-HT release and granule pH.
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