Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization

对疟疾、HIV 和 SARS-CoV-2 感染的免疫反应和免疫接种

• 批准号: 10419580
• 负责人: Margaret Juliana McElrath
• 金额: $ 207.15万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10419580
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adjuvant; Affect; Characteristics; Communicable Diseases; Communities; Data Analyses; Development; Disease; Environmental Exposure; Falciparum Malaria; Foundations; Future; Goals; HIV; HIV-1; Health Status; Human; Human Characteristics; Immune; Immune response; Immune system; Immunity; Immunization; Immunology; Infection; Malaria; Molecular Profiling; Outcome; Persons; Plasmodium falciparum; Population; Predisposition; Prevention; Prevention strategy; Process; Research; Resolution; SARS-CoV-2 infection; System; Systems Biology; Technical Expertise; Technology; Therapeutic; Vaccination; Vaccines; Variant; coronavirus disease; data standards; design; human disease; insight; malaria infection; novel; novel therapeutics; pathogen; response; treatment strategy; vaccine development; vaccine efficacy; vaccine strategy

ABSTRACT (Overall) Malaria, HIV/AIDS, and Covid are three of the most devastating infectious diseases, impacting millions of people world-wide. Effective vaccines against the pathogens that cause these diseases (HIV, SARS-CoV-2 and Plasmodium falciparum) have proven elusive and/or affected by pathogen variation and thus traditional vaccine approaches are unlikely to succeed in eradicating these diseases. In addition to our limited understanding of the desired immune responses to confer protection against the pathogens and our limited ability to elicit such responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental exposures, and health status. The projects described herein are designed to support the identification of immune profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1, SARS CoV-2 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into the complexity of the human immune system. Such insights have the potential to impact strategies for vaccine development and for producing new therapies for many diseases.

摘要（总体） 疟疾，艾滋病毒/艾滋病和库维德是三种最具破坏性的传染病，影响了数百万的人 全世界。针对引起这些疾病的病原体的有效疫苗（HIV，SARS-COV-2和 恶性疟原虫）已证明难以捉摸和/或受病原体变异的影响，因此传统疫苗 方法不太可能成功消除这些疾病。除了我们对 期望的免疫反应以赋予对病原体的保护以及我们有限的引起这种能力 反应，疫苗功效也与病原体，人类，环境的多样性相混淆 暴露和健康状况。本文所述的项目旨在支持免疫的识别 与疫苗功效相关的轮廓，并且可能与保护HIV-1的保护相关，SARS COV-2和恶性疟原虫感染。除了打击这些疾病的重要性之外， 响应感染和疫苗接种的免疫力对获得基本见解的承诺有望 人免疫系统的复杂性。这种见解有可能影响疫苗的策略 开发和生产许多疾病的新疗法。