Immune Responses to Malaria and HIV Infection and Immunization - Clinical Core

对疟疾和艾滋病毒感染的免疫反应和免疫接种 - 临床核心

• 批准号: 10198679
• 负责人: Margaret Juliana McElrath
• 金额: $ 16.28万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198679
• 关键词: Bone Marrow; Clinical; Clinical Medicine; Clinical Trials; Collaborations; Communicable Diseases; Consent; Cryopreservation; Enrollment; Fred Hutchinson Cancer Research Center; Future; HIV; HIV Infections; HIV immunization; HIV-1 vaccine; Human; Human Subject Research; Human Volunteers; Immune; Immune response; Immunologics; Immunology; Malaria; Modeling; Mucous Membrane; Natural History; Participant; Peripheral Blood Mononuclear Cell; Plasma; Prevention; Procedures; Research; Research Support; Resources; Sampling; Serum; Source; Specimen; Tissue Sample; Vaccines; base; cohort; design; lymph nodes; malaria infection; minimally invasive; sample archive; treatment trial; vaccine trial; volunteer

The Clinical Core, based within the Vaccine and Infectious Disease Division (VIDD) at Fred Hutchinson Cancer Research Center (FHCRC), will provide relevant expertise in clinical medicine, human subjects research, vaccine trials, and human immunology in support of the scientific aims of the Collaboration focused on the prevention and control of malaria and HIV. In order to most efficiently support the diverse aims of Collaboration projects, the CC will utilize a variety of resources including: 1) archived samples (e.g., cryopreserved PBMC, serum, plasma) from study participants in relevant completed or ongoing clinical trials, which comprise the primary source of clinical samples for Collaboration projects; 2) newly obtained samples from existing clinical natural history and control cohorts and from specifically designed sub-studies to enable more comprehensive analysis within ongoing or planned vaccine or treatment trials; and 3) samples acquired through the clinical expertise of collaborating clinicians accomplished in the safe sampling of specialized immunological reservoirs (e.g., bone marrow; lymph nodes; mucosa) using minimally invasive procedures in human volunteers.

弗雷德·哈钦森癌症公司疫苗和传染病部门(VIDD)的临床核心 研究中心(FHCRC)将提供临床医学、人体研究、 疫苗试验和人类免疫学，以支持合作的科学目标，重点是 预防和控制疟疾和艾滋病毒。为了最有效地支持协作的不同目标 对于项目，CC将利用各种资源，包括：1)存档样本(例如，冷冻保存的PBMC， 血清、血浆)来自相关已完成或正在进行的临床试验的研究参与者，这些试验包括 协作项目的主要临床样本来源；2)从现有临床样本中新获得的样本 自然历史和控制队列以及来自专门设计的子研究，以实现更全面的 正在进行或计划中的疫苗或治疗试验中的分析；以及3)通过临床获得的样本 合作的临床医生在专业免疫储存库的安全采样方面的专业知识 (例如，骨髓、淋巴结、粘膜)在人类志愿者中使用微创程序。