Immune Responses to Malaria and HIV Infection and Immunization - Clinical Core

临床核心，位于弗雷德哈钦森癌症疫苗和传染病部（VIDD） 研究中心（FHCRC），将提供临床医学，人类受试者研究， 疫苗试验和人类免疫学，以支持合作的科学目标， 预防和控制疟疾和艾滋病毒。为了最有效地支持协作的各种目标， 项目，CC将利用各种资源，包括：1）存档样本（例如，冷冻保存的PBMC， 血清、血浆），其包括来自相关已完成或正在进行的临床试验中的研究参与者的 合作项目临床样本的主要来源; 2）从现有临床样本中新获得的样本 自然史和对照队列，以及专门设计的子研究， 正在进行或计划进行的疫苗或治疗试验中的分析;以及3）通过临床试验获得的样本 合作临床医生的专业知识，在专门的免疫水库的安全采样完成 (e.g.,骨髓;淋巴结;粘膜）。

The Clinical Core, based within the Vaccine and Infectious Disease Division (VIDD) at Fred Hutchinson Cancer Research Center (FHCRC), will provide relevant expertise in clinical medicine, human subjects research, vaccine trials, and human immunology in support of the scientific aims of the Collaboration focused on the prevention and control of malaria and HIV. In order to most efficiently support the diverse aims of Collaboration projects, the CC will utilize a variety of resources including: 1) archived samples (e.g., cryopreserved PBMC, serum, plasma) from study participants in relevant completed or ongoing clinical trials, which comprise the primary source of clinical samples for Collaboration projects; 2) newly obtained samples from existing clinical natural history and control cohorts and from specifically designed sub-studies to enable more comprehensive analysis within ongoing or planned vaccine or treatment trials; and 3) samples acquired through the clinical expertise of collaborating clinicians accomplished in the safe sampling of specialized immunological reservoirs (e.g., bone marrow; lymph nodes; mucosa) using minimally invasive procedures in human volunteers.