Immune Responses to Malaria and HIV Infection and Immunization - Clinical Core

对疟疾和艾滋病毒感染的免疫反应和免疫接种 - 临床核心

• 批准号: 10198679
• 负责人: Margaret Juliana McElrath
• 金额: $ 16.28万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-19 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198679
• 关键词: Bone Marrow; Clinical; Clinical Medicine; Clinical Trials; Collaborations; Communicable Diseases; Consent; Cryopreservation; Enrollment; Fred Hutchinson Cancer Research Center; Future; HIV; HIV Infections; HIV immunization; HIV-1 vaccine; Human; Human Subject Research; Human Volunteers; Immune; Immune response; Immunologics; Immunology; Malaria; Modeling; Mucous Membrane; Natural History; Participant; Peripheral Blood Mononuclear Cell; Plasma; Prevention; Procedures; Research; Research Support; Resources; Sampling; Serum; Source; Specimen; Tissue Sample; Vaccines; base; cohort; design; lymph nodes; malaria infection; minimally invasive; sample archive; treatment trial; vaccine trial; volunteer

The Clinical Core, based within the Vaccine and Infectious Disease Division (VIDD) at Fred Hutchinson Cancer Research Center (FHCRC), will provide relevant expertise in clinical medicine, human subjects research, vaccine trials, and human immunology in support of the scientific aims of the Collaboration focused on the prevention and control of malaria and HIV. In order to most efficiently support the diverse aims of Collaboration projects, the CC will utilize a variety of resources including: 1) archived samples (e.g., cryopreserved PBMC, serum, plasma) from study participants in relevant completed or ongoing clinical trials, which comprise the primary source of clinical samples for Collaboration projects; 2) newly obtained samples from existing clinical natural history and control cohorts and from specifically designed sub-studies to enable more comprehensive analysis within ongoing or planned vaccine or treatment trials; and 3) samples acquired through the clinical expertise of collaborating clinicians accomplished in the safe sampling of specialized immunological reservoirs (e.g., bone marrow; lymph nodes; mucosa) using minimally invasive procedures in human volunteers.

临床核心，基于弗雷德·哈钦森癌的疫苗和传染病分裂（VIDD）内的临床核心 研究中心（FHCRC）将提供临床医学，人类受试者研究的相关专业知识， 疫苗试验和人类免疫学支持合作的科学目的 预防和控制疟疾和艾滋病毒。为了最有效地支持合作的不同目标 项目，CC将利用各种资源，包括：1）存档样本（例如冷冻保存PBMC， 血清，等离子体）来自相关完成或正在进行的临床试验的研究参与者，其中包括 合作项目的临床样本的主要来源； 2）从现有临床中新获得的样品 自然历史和控制队列，以及从专门设计的子培训中，以实现更全面的 在正在进行或计划的疫苗或治疗试验中进行分析； 3）通过临床获取的样品 合作在安全取样专业免疫库中完成的合作临床医生的专业知识 （例如，骨髓；淋巴结；粘膜）使用人类志愿者中的微创手术。