Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Clinical Core

临床核心中心将继续在临床传染病和人类疾病方面提供领导和专业知识 支持HIPC3的主题研究和我们合作的三个科学项目专注于 疟疾、HIV-1和SARS-CoV-2预防和感染的综合免疫分析。基于 弗雷德·哈钦森癌症研究中心疫苗和传染病部门，临床核心将 建立、实施和监督临床队列观察研究和嵌套人类免疫学研究 在临床疫苗试验中，以获得用于深入免疫图谱研究的纵向标本。 为了实现我们的目标，我们建议提供临床基础设施、领导力、专业知识和进行 代表我们与HIPC3的合作，通过观察性的方式对人类传染病进行研究 研究和亚研究嵌套在现有和未来的临床试验中。我们还致力于设计、开发、 实施和维护精心策划的临床队列和疫苗试验子研究，以获取样本用于 感染期间、感染后或感染前与疟疾、HIV-1和SARS-CoV-2相关的免疫概况研究 并在免疫后。

The Clinical Core will continue to provide the leadership and expertise in clinical infectious diseases and human subjects research to support the HIPC3 and our collaboration’s three scientific projects focused on comprehensive immune analysis of malaria, HIV-1 and SARS-CoV-2 prevention and infection. Based within the Vaccine and Infectious Disease Division at Fred Hutchinson Cancer Research Center, the Clinical Core will establish, conduct and oversee clinical cohort observational studies and human immunology studies nested within clinical vaccine trials in order to obtain longitudinal specimens for deep immune profiling investigations. To accomplish our goals, we propose to provide the clinical infrastructure, leadership, expertise and to conduct human subjects research in infectious diseases on behalf of our HIPC3 Collaboration through observational studies and sub-studies nested within existing and future clinical trials. We also aim to design, develop, implement and maintain well-curated clinical cohorts and vaccine trial sub-studies to acquire specimens for immune profiling studies relevant to malaria, HIV-1 and SARS-CoV-2, either during or after infection, or before and after immunization.