权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast Asia

了解东南亚 EID 热点地区人畜共患病毒出现的风险

基本信息

批准号：
10427219
负责人：
Peter Daszak
金额：
$ 150.44万
依托单位：
ECOHEALTH ALLIANCE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-17 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10427219
关键词：
Animal Model Animals Archives Asia Asian Behavioral Biological Biological Assay Biology Cell Culture Techniques China Chiroptera Clinic Clinical Clinical Management Collaborations Collection Communicable Diseases Communities Country Dangerousness Data Data Analyses Demography Development Disease Disease Outbreaks Emerging Communicable Diseases Encephalitis Enrollment Epidemiology Etiology Event Exposure to Family Family suidae Far East Frequencies Geography Goals Hospitals Human Human Resources In Vitro Infection Infectious Diseases Research Influenza Institution International Investigation Laboratory Research Leadership Link Livestock Malaysian Mammals Metadata Modeling Molecular Mus Nipah Virus Occupational Pathogenicity Pathway interactions Patients Persons Phylogenetic Analysis Population Primates Probability Questionnaires Reagent Research Research Institute Research Personnel Resources Risk Risk Factors Rodent Rural Community Sampling Scientist Series Serodiagnoses Serology Serology test Severe Acute Respiratory Syndrome Singapore Southeastern Asia Surveys Symptoms Syndrome System Taxonomy Technology Testing Thailand Translational Research Viral Virus Work Zoonoses cohort community clinic design diagnostic assay experience experimental study follow-up fundamental research high risk human data humanized mouse in vivo influenza outbreak influenza virus strain intervention program multidisciplinary novel novel coronavirus novel virus pandemic disease pathogen pathogenic virus receptor binding respiratory scale up serosurvey southeast Asian syndromic surveillance transmission process

项目摘要

PROJECT SUMMARY/ABSTRACT Southeast Asia is one of the world’s highest-risk EID hotspots, the origin of the SARS pandemic, Nipah virus, and repeated outbreaks of influenza. This is driven by high diversity of wildlife and rapidly expanding demography that brings human and wildlife populations closer. This proposal will launch the Emerging Infectious Diseases - South East Asia Research Collaboration Hub (EID-SEARCH), a collaboration among leaders in emerging disease research in the USA, Thailand, Singapore and the 3 major Malaysian administrative regions. These researchers have networks that span >50 clinics, laboratories and research institutions across almost all SE Asian countries and will use the EID-SEARCH as an early warning system for outbreaks involving exchange of information, reagents, samples and technology, and a collaborative power- house for fundamental and translational research. The EID-SEARCH will also act as a significant asset to scale-up and deploy resources in the case of an outbreak in the region. This EIDRC will conduct research to: 1) Identify, characterize and rank spillover risk of high zoonotic potential viruses from wildlife, by analyzing previously-archived wildlife samples, conducting targeted wildlife surveillance, and using serology & PCR assays to identify novel viruses. These will be characterized to assess risk of spillover to people, and a series of in vitro (receptor binding, cell culture) and in vivo (humanized mouse and collaborative cross models) assays used to assess their potential to infect people and cause disease; 2) Collect samples and questionnaire data from human communities that live in EID hotspots and have high cultural and behavioral risk of animal exposure (e.g. wildlife hunting, bat guano collection). These will be tested with serological assays to identify evidence of novel virus spillover, and analyzed against metadata to identify key risk pathways for transmission; 3) Identify and characterize viral etiology of ‘cryptic’ outbreaks in clinical cohorts. We will conduct syndromic surveillance at clinics serving the populations in Aim 2, enroll patients with undiagnosed illness and symptoms consistent with emerging viral pathogens, and test samples with molecular and follow-up serological assays to identify causal links between these syndromes and novel viruses. This research will advance our understanding of the risk of novel viral emergence in a uniquely important region. It will also strengthen in-country research capacity by linking local infectious disease scientists with an international collaborative network that has proven capacity to conduct this work and produce significant findings. The large body of high impact collaborative research from this EIDRC leadership team provides proof-of-concept that EID-SEARCH has the background, collaborative network, experience, and skillset to act as a unique early warning system for novel EIDs of any etiology threatening to emerge in this hottest of the EID hotspots.

项目总结/文摘