Translational Research Training on Aging and Mobility (TRAM)

保持活动能力是老年护理、老年学和老年学的标志之一。机动性的丧失 衰老是渐进性的，由多种因素引起，没有简单的治疗方法。不幸的是，行动不便 仍然缺乏临床关注、强大的生物医学目标、客观测量的监测系统，以及 有效的治疗方法。因此，自成立以来，流动困难一直居高不下，停滞不前。 S在20世纪80年代末进行了系统的测量。目前，30%的60-69岁的美国人，40%的年龄在 70-79岁，55%的80岁或以上的人报告行动不便(如行走和攀登 楼梯)。为了解决这一未得到满足的需求，我们提出了关于老龄化和流动性的翻译研究培训 (TRAM)博士后培训计划，每年培训4名博士后研究员(第一年2名)。总目标 有轨电车计划的目的是培养优秀的独立调查人员，能够保持生产力 多学科和转化性研究职业，研究多因素的原因和后果 与年龄有关的活动变化和/或设计多种模式的干预措施以预防和恢复活动 老年人的身体缺陷。目标是：1)为博士/医学博士提供2-3年的综合培训计划 研究员为进行机械性和临床相关的翻译研究创造一条职业道路 2)实施基于体验式学习理论的交叉培养方案； 3)使受训人员掌握新的研究技能以及知识和专业知识，以应对 关于流动性和老龄化的悬而未决的问题；4)密切监测和跟踪学员的相关经历 和持续质量改进的结果；5)创造一种专业卓越的文化 在加强受训人员相关研究的严谨性、可重复性和透明度的基础上进行发展； 6)吸引、招募和招收少数群体、残疾人和弱势群体。有轨电车 项目教师是彼此项目的合作者，带来了强大的指导经验和成功 致力于与机动性和/或老龄化相关的研究。计划教职员工分为老龄化或 基于研究重点和专业知识的移动性研究集群。有轨电车将使用马赛克指导 将采用双重主要导师的方法--一个来自“老龄化”专业知识，另一个来自“移动性”专业知识--a Third Mentor将担任倡导者/赞助人。学员还将获得其他原型的支持，如 教练、联络员和资深同伴导师。这个统一的指导团队将指导学员通过 个人发展计划，教学课程(例如，关于老龄化的机械学和临床研究 和/或流动性、道德、负责任的研究行为)、定向研究培训和专业人员 发展活动(如战略规划、创新领导力)将根据 学员的教育需求和研究兴趣。完成后，有轨电车研究员将完成科学 需要并增加研究人员，以满足日益增长的行动不便老年人人口。

Preserved mobility is one of hallmarks of geriatric care, gerontology and geroscience. The loss of mobility with aging is progressive, caused by multiple factors and does not have a simple cure. Unfortunately, mobility loss continues to lack clinical attention, robust biomedical targets, objectively-measured surveillance systems, and effective treatments. As a result, mobility difficulties have remained persistently high and stagnant since it was systematically measured in the late 1980's. Currently, 30% of Americans aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older report difficulties with their mobility (e.g. walking and climbing stairs). To address this unmet need, we propose the Translational Research training on Aging and Mobility (TRAM) postdoctoral training program to train 4 post-doctoral fellows per year (2 in year one). The overall goal of the TRAM program is to develop outstanding independent investigators capable of sustaining productive multi-disciplinary and translational research careers addressing the multi-factorial causes and consequences of age-related changes in mobility and/or designing multi-modal interventions to prevent and rehabilitate mobility impairments in older adults. The goals are to: 1) Provide a 2-3 year integrated training program for PhD/MD fellows to create a career pathway for conducting mechanistic and clinically relevant translational research in mobility and aging; 2) Implement a cross-fertilized training program based on the Experiential Learning Theory; 3) To equip trainees with new research skills along with the knowledge and expertise to address impactful and unanswered questions regarding mobility and aging; 4) Closely monitor and track trainee-related experiences and outcomes for making continuous quality improvements; 5) Create a culture for professional excellence and development based on enhancing rigor, reproducibility and transparency in trainee-related research and; 6) To attract, recruit and enroll minorities, and those with disabilities and disadvantaged backgrounds. TRAM program faculty are collaborators on each other's projects, bring strong mentorship experience and successful commitment to research related to mobility and/or aging. Program faculty are grouped into either Aging or Mobility Research Clusters based on research focus and expertise. TRAM will use a mosaic mentoring approach that will employ dual primary mentors— one from “aging” and another from “mobility” expertise— a third mentor will serve as an advocate/sponsor. Mentees will also receive support from other archetypes like coaches, connectors and senior peer mentors. This unified mentoring team will guide trainees through an individual development plan, didactic coursework (e.g. mechanistic and clinical-based research on aging and/or mobility, ethics, responsible conduct of research), directed research training, and professional development activities (e.g. strategic planning, innovative leadership) that will be tailored according to the educational needs and research interests of the trainee. At completion, TRAM fellows will fulfill the scientific needs and grow the research workforce for meeting the growing population of mobility impaired older adults.