Translational Research Training on Aging and Mobility (TRAM)

保持活动能力是老年护理、老年学和老年科学的标志之一。丧失流动性， 衰老是渐进的，由多种因素引起，没有简单的治疗方法。不幸的是，行动不便 仍然缺乏临床关注，强大的生物医学目标，客观测量的监测系统， 有效的治疗。因此，自2010年以来，流动困难一直居高不下，停滞不前。 在1980年代后期进行了系统的测量。目前，30%的60-69岁的美国人，40%的 70-79岁，55%的80岁或80岁以上的人报告他们的行动困难（例如行走和攀爬 楼梯）。为了解决这一未满足的需求，我们提出了老龄化和流动性转化研究培训 （TRAM）博士后培训计划，每年培训4名博士后研究员（第一年2名）。总目标 TRAM计划的目标是培养能够保持生产力的优秀独立调查员 多学科和翻译研究的职业生涯，解决多因素的原因和后果， 与年龄有关的流动性变化和/或设计多模式干预措施，以预防和恢复流动性 老年人的残疾。目标是：1）为博士/博士提供2-3年的综合培训计划 研究员创建一个职业道路进行机械和临床相关的转化研究， 2）实施基于体验学习理论的交叉培训计划; 3)为学员提供新的研究技能，沿着知识和专业知识，以解决有影响力和 关于流动性和老龄化的未回答的问题; 4）密切监测和跟踪与受训者相关的经验 5）创造追求卓越的专业文化 和发展的基础上，提高严谨性，再现性和透明度，在受训者相关的研究和; 6)吸引、招聘和招收少数族裔、残疾人和弱势群体。电车 项目教师是彼此项目的合作者，带来了强大的导师经验和成功的 致力于与流动性和/或老龄化相关的研究。计划教师分为老龄化或 基于研究重点和专业知识的流动性研究集群。TRAM将使用马赛克指导 一种方法，将雇用双重主要导师-一个来自“老龄化”，另一个来自“流动性”的专业知识- 第三位导师将担任倡导者/赞助者。学员还将获得其他原型的支持，如 教练，连接器和高级同行导师。这个统一的指导小组将通过一个 个人发展计划，教学课程（如关于衰老的机械和临床研究 和/或流动性，道德，负责任的研究行为），指导研究培训，和专业 发展活动（如战略规划、创新领导），将根据 学员的教育需求和研究兴趣。完成后，TRAM研究员将完成科学的 需要和增长的研究队伍，以满足不断增长的人口行动不便的老年人。

Preserved mobility is one of hallmarks of geriatric care, gerontology and geroscience. The loss of mobility with aging is progressive, caused by multiple factors and does not have a simple cure. Unfortunately, mobility loss continues to lack clinical attention, robust biomedical targets, objectively-measured surveillance systems, and effective treatments. As a result, mobility difficulties have remained persistently high and stagnant since it was systematically measured in the late 1980's. Currently, 30% of Americans aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older report difficulties with their mobility (e.g. walking and climbing stairs). To address this unmet need, we propose the Translational Research training on Aging and Mobility (TRAM) postdoctoral training program to train 4 post-doctoral fellows per year (2 in year one). The overall goal of the TRAM program is to develop outstanding independent investigators capable of sustaining productive multi-disciplinary and translational research careers addressing the multi-factorial causes and consequences of age-related changes in mobility and/or designing multi-modal interventions to prevent and rehabilitate mobility impairments in older adults. The goals are to: 1) Provide a 2-3 year integrated training program for PhD/MD fellows to create a career pathway for conducting mechanistic and clinically relevant translational research in mobility and aging; 2) Implement a cross-fertilized training program based on the Experiential Learning Theory; 3) To equip trainees with new research skills along with the knowledge and expertise to address impactful and unanswered questions regarding mobility and aging; 4) Closely monitor and track trainee-related experiences and outcomes for making continuous quality improvements; 5) Create a culture for professional excellence and development based on enhancing rigor, reproducibility and transparency in trainee-related research and; 6) To attract, recruit and enroll minorities, and those with disabilities and disadvantaged backgrounds. TRAM program faculty are collaborators on each other's projects, bring strong mentorship experience and successful commitment to research related to mobility and/or aging. Program faculty are grouped into either Aging or Mobility Research Clusters based on research focus and expertise. TRAM will use a mosaic mentoring approach that will employ dual primary mentors— one from “aging” and another from “mobility” expertise— a third mentor will serve as an advocate/sponsor. Mentees will also receive support from other archetypes like coaches, connectors and senior peer mentors. This unified mentoring team will guide trainees through an individual development plan, didactic coursework (e.g. mechanistic and clinical-based research on aging and/or mobility, ethics, responsible conduct of research), directed research training, and professional development activities (e.g. strategic planning, innovative leadership) that will be tailored according to the educational needs and research interests of the trainee. At completion, TRAM fellows will fulfill the scientific needs and grow the research workforce for meeting the growing population of mobility impaired older adults.