Translational Research Training in Hepatology

肝病学转化研究培训

• 批准号: 10620808
• 负责人: Rohit Kohli
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620808
• 关键词: Hepatology; Research Training; Translational Research

Summary/Abstract: This application to establish a postdoctoral T32 training program in Translational Research in Hepatology to be administered at the University of Southern California (USC) Keck School of Medicine in conjunction with the Children's Hospital Los Angeles (CHLA), with affiliations at the USC Schaeffer Center for Health Policy and Economics. This training program leverages substantial university and department level investments in research infrastructure and faculty recruits, a steady rise in the quality of the training-grant-eligible applicant pool and the rich diversity of patient populations in Los Angeles to provide a robust research training experience. This Program is focused on training physician-scientists who are accepted to USC/CHLA Gastroenterology fellowships and will provide up to 3 years of support for intensive laboratory or clinical research training and mentored research for 10 MD (or MD/PhD) trainees over five years. Trainees will conduct laboratory, clinical and/or translational research (T1-T4 spectrum) under the mentorship of 16 highly qualified research mentors who have a solid track record of NIH (NIDDK) funding and exceptional mentoring accomplishments. Research themes of (i) Hepatic Immunology, Injury and Regeneration; (ii) Hepatic Steatosis and Fibrosis; and (iii) Clinical Outcomes and Community/Healthcare Implementation reflect the research strengths and training opportunities within well-established research collaborations at USC/CHLA. An individualized curriculum will focus on building each trainee’s research knowledge base, critical investigative abilities and technical skills, with diligent oversight of the training progress by primary mentors, as well as mentoring and executive committees. The institutional environment at USC/CHLA and affiliates provides abundant resources (research institutes and centers with a wide range of cores), a rich intellectual milieu for training in digestive diseases research including masters’ level training in clinical research methods, and dedicated trainee-mentor activities including an annual fellow-led symposium, biweekly work-in-progress meetings, and monthly journal clubs. Further, this training program occurs in the multi-ethic environment of Los Angeles, providing a unique educational opportunity to study liver diseases in minority populations. The ultimate goal of this T32 Training Program is to prepare GI trainees to assume a faculty-level position and compete successfully for independent research funding across the spectrum of translational liver diseases research to address the significant burden of liver disorders in the U.S. and globally.

摘要/摘要：此申请用于建立翻译研究中的博士后T32培训计划 肝病学将在南加州大学凯克医学院管理 与洛杉矶儿童医院(CHLA)合作，与南加州大学谢弗中心合作 卫生政策与经济学。这一培训计划充分利用了大学和系的水平 对研究基础设施和教师招聘的投资，稳步提高符合资格的培训拨款的质量 申请者人才库和丰富多样的患者群体在洛杉矶提供强大的研究培训 经验。该计划的重点是培训被南加州大学/中国洛杉矶分校录取的内科科学家 胃肠病研究奖学金，并将为密集的实验室或临床研究提供长达3年的支持 在五年内对10名医学博士(或医学博士)学员进行培训和指导研究。受训者将进行实验室， 在16项高质量研究的指导下进行临床和/或转化性研究(T1-T4谱) 在美国国立卫生研究院(NIH)资助方面有良好记录并在指导方面取得卓越成就的导师。 研究主题：(I)肝脏免疫学、损伤和再生；(Ii)肝脏脂肪变性和纤维化；以及 (3)临床成果和社区/保健执行情况反映了研究力量和培训 南加州大学/加州大学洛杉矶分校成熟的研究合作中的机会。个性化的课程将 重点建设每个学员的研究知识库、关键调查能力和技术技能， 主要导师以及指导和执行委员会对培训进展的勤勉监督。 南加州大学/CHLA及其附属机构的机构环境提供了丰富的资源(研究机构和 具有广泛核心的中心)，为消化疾病研究培训提供了丰富的智力环境，包括 临床研究方法的硕士水平培训，以及专门的实习生-导师活动，包括每年一次的 同事主导的研讨会、两周一次的工作进展会议和每月一次的期刊俱乐部。此外，这一培训 计划发生在洛杉矶的多种族环境中，提供了一个独特的教育机会 研究少数民族人群中的肝病。此T32培训计划的最终目标是准备GI 受训人员将担任教职员工级别的职位，并成功竞争各领域的独立研究资金 翻译肝病研究的光谱，以解决肝脏疾病的重大负担 美国和全球都是如此。

项目成果

A Case of Pediatric Alcohol-Associated Hepatitis Evaluated for Liver Transplant Listing.

• DOI: 10.1097/pg9.0000000000000311
• 发表时间: 2023-05
• 期刊: JPGN reports

Elevated liver enzymes: unusual presentation of anti-MDA5 antibody-associated juvenile dermatomyositis.

肝酶升高：抗 MDA5 抗体相关幼年皮肌炎的异常表现。

• DOI: 10.55563/clinexprheumatol/25znui
• 发表时间: 2024
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Yi,BelinaY;Marrs,Joshua;Schenker,Rachel;Suddock,Jolee;Cotter,JenniferA;Cidon,Michal
• 通讯作者: Cidon,Michal

Recurrent Rectal Prolapse Successfully Treated With Polyethylene Glycol.

• DOI: 10.1097/pg9.0000000000000380
• 发表时间: 2023-11
• 期刊: JPGN reports