Translational Research Training in Hepatology

肝病学转化研究培训

• 批准号: 10620808
• 负责人: Rohit Kohli
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620808
• 关键词: Hepatology; Research Training; Translational Research

Summary/Abstract: This application to establish a postdoctoral T32 training program in Translational Research in Hepatology to be administered at the University of Southern California (USC) Keck School of Medicine in conjunction with the Children's Hospital Los Angeles (CHLA), with affiliations at the USC Schaeffer Center for Health Policy and Economics. This training program leverages substantial university and department level investments in research infrastructure and faculty recruits, a steady rise in the quality of the training-grant-eligible applicant pool and the rich diversity of patient populations in Los Angeles to provide a robust research training experience. This Program is focused on training physician-scientists who are accepted to USC/CHLA Gastroenterology fellowships and will provide up to 3 years of support for intensive laboratory or clinical research training and mentored research for 10 MD (or MD/PhD) trainees over five years. Trainees will conduct laboratory, clinical and/or translational research (T1-T4 spectrum) under the mentorship of 16 highly qualified research mentors who have a solid track record of NIH (NIDDK) funding and exceptional mentoring accomplishments. Research themes of (i) Hepatic Immunology, Injury and Regeneration; (ii) Hepatic Steatosis and Fibrosis; and (iii) Clinical Outcomes and Community/Healthcare Implementation reflect the research strengths and training opportunities within well-established research collaborations at USC/CHLA. An individualized curriculum will focus on building each trainee’s research knowledge base, critical investigative abilities and technical skills, with diligent oversight of the training progress by primary mentors, as well as mentoring and executive committees. The institutional environment at USC/CHLA and affiliates provides abundant resources (research institutes and centers with a wide range of cores), a rich intellectual milieu for training in digestive diseases research including masters’ level training in clinical research methods, and dedicated trainee-mentor activities including an annual fellow-led symposium, biweekly work-in-progress meetings, and monthly journal clubs. Further, this training program occurs in the multi-ethic environment of Los Angeles, providing a unique educational opportunity to study liver diseases in minority populations. The ultimate goal of this T32 Training Program is to prepare GI trainees to assume a faculty-level position and compete successfully for independent research funding across the spectrum of translational liver diseases research to address the significant burden of liver disorders in the U.S. and globally.

摘要/摘要：本申请建立转化研究博士后T32培养项目 将在南加州大学（USC）凯克医学院进行肝病学研究， 与洛杉矶儿童医院（CHLA）合作，与南加州大学谢弗中心合作， 卫生政策和经济学。该培训计划充分利用了大学和部门的水平 投资于研究基础设施和教师招聘，培训补助金资格的质量稳步上升， 申请人库和洛杉矶患者人群的丰富多样性，以提供强大的研究培训 体验.该计划的重点是培训被USC/CHLA接受的医生-科学家 胃肠病学奖学金，并将为密集的实验室或临床研究提供长达3年的支持 在五年内为10名MD（或MD/PhD）学员提供培训和指导研究。学员将进行实验， 临床和/或转化研究（T1-T4光谱）在16个高质量的研究指导下 导师谁拥有NIH（NIDDK）资金和卓越的指导成就的坚实的跟踪记录。 研究主题：（i）肝脏免疫、损伤和再生;（ii）肝脏脂肪变性和纤维化;以及 (iii)临床结果和社区/医疗保健实施反映了研究优势和培训 在USC/CHLA建立良好的研究合作的机会。个性化的课程将 注重建立每个受训者的研究知识基础、关键调查能力和技术技能， 主要导师以及指导委员会和执行委员会对培训进度进行认真监督。 南加州大学/CHLA及其附属机构的体制环境提供了丰富的资源（研究机构和 中心与广泛的核心），一个丰富的知识环境，培训消化系统疾病的研究，包括 临床研究方法的硕士水平培训，以及专门的受训者导师活动，包括年度 研究员领导的专题讨论会、双周工作进展会议和每月期刊俱乐部。此外，本次培训 该计划发生在洛杉矶的多民族环境，提供了一个独特的教育机会， 研究少数民族的肝脏疾病。这个T32培训计划的最终目标是准备GI 学员担任学院级别的职位，并成功地竞争独立的研究经费， 转化性肝脏疾病研究的范围，以解决肝脏疾病的重大负担 美国和全球范围内。

项目成果

A Case of Pediatric Alcohol-Associated Hepatitis Evaluated for Liver Transplant Listing.

• DOI: 10.1097/pg9.0000000000000311
• 发表时间: 2023-05
• 期刊: JPGN reports

Elevated liver enzymes: unusual presentation of anti-MDA5 antibody-associated juvenile dermatomyositis.

肝酶升高：抗 MDA5 抗体相关幼年皮肌炎的异常表现。

• DOI: 10.55563/clinexprheumatol/25znui
• 发表时间: 2024
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Yi,BelinaY;Marrs,Joshua;Schenker,Rachel;Suddock,Jolee;Cotter,JenniferA;Cidon,Michal
• 通讯作者: Cidon,Michal

Recurrent Rectal Prolapse Successfully Treated With Polyethylene Glycol.

• DOI: 10.1097/pg9.0000000000000380
• 发表时间: 2023-11
• 期刊: JPGN reports