Translational Research Training in Hepatology

肝病学转化研究培训

• 批准号: 10620808
• 负责人: Rohit Kohli
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620808
• 关键词: Hepatology; Research Training; Translational Research

Summary/Abstract: This application to establish a postdoctoral T32 training program in Translational Research in Hepatology to be administered at the University of Southern California (USC) Keck School of Medicine in conjunction with the Children's Hospital Los Angeles (CHLA), with affiliations at the USC Schaeffer Center for Health Policy and Economics. This training program leverages substantial university and department level investments in research infrastructure and faculty recruits, a steady rise in the quality of the training-grant-eligible applicant pool and the rich diversity of patient populations in Los Angeles to provide a robust research training experience. This Program is focused on training physician-scientists who are accepted to USC/CHLA Gastroenterology fellowships and will provide up to 3 years of support for intensive laboratory or clinical research training and mentored research for 10 MD (or MD/PhD) trainees over five years. Trainees will conduct laboratory, clinical and/or translational research (T1-T4 spectrum) under the mentorship of 16 highly qualified research mentors who have a solid track record of NIH (NIDDK) funding and exceptional mentoring accomplishments. Research themes of (i) Hepatic Immunology, Injury and Regeneration; (ii) Hepatic Steatosis and Fibrosis; and (iii) Clinical Outcomes and Community/Healthcare Implementation reflect the research strengths and training opportunities within well-established research collaborations at USC/CHLA. An individualized curriculum will focus on building each trainee’s research knowledge base, critical investigative abilities and technical skills, with diligent oversight of the training progress by primary mentors, as well as mentoring and executive committees. The institutional environment at USC/CHLA and affiliates provides abundant resources (research institutes and centers with a wide range of cores), a rich intellectual milieu for training in digestive diseases research including masters’ level training in clinical research methods, and dedicated trainee-mentor activities including an annual fellow-led symposium, biweekly work-in-progress meetings, and monthly journal clubs. Further, this training program occurs in the multi-ethic environment of Los Angeles, providing a unique educational opportunity to study liver diseases in minority populations. The ultimate goal of this T32 Training Program is to prepare GI trainees to assume a faculty-level position and compete successfully for independent research funding across the spectrum of translational liver diseases research to address the significant burden of liver disorders in the U.S. and globally.

摘要/摘要：本申请建立转化研究博士后T32培训项目 肝病学博士将在南加州大学 (USC) 凯克医学院进行 与洛杉矶儿童医院 (CHLA) 合作，隶属于南加州大学谢弗中心 卫生政策和经济学。该培训计划充分利用了大学和院系的水平 对研究基础设施和教师招聘的投资，培训补助金资格的质量稳步提高 洛杉矶的申请人库和患者群体的丰富多样性可提供强大的研究培训 经验。该计划的重点是培训被南加州大学/CHLA 录取的医师科学家 胃肠病学奖学金将为密集实验室或临床研究提供长达 3 年的支持 五年内为 10 名医学博士（或医学博士/博士）学员提供培训和指导研究。学员将进行实验室、 在 16 名高素质研究人员的指导下进行临床和/或转化研究（T1-T4 谱） 拥有 NIH (NIDDK) 资助良好记录和杰出指导成就的导师。 研究主题： (i) 肝脏免疫学、损伤与再生； (ii) 肝脏脂肪变性和纤维化；和 (iii) 临床结果和社区/医疗保健实施反映了研究优势和培训 南加州大学/CHLA 完善的研究合作机会。个性化的课程将 重点培养每位学员的研究知识库、关键调查能力和技术技能， 主要导师以及指导委员会和执行委员会对培训进度进行认真监督。 USC/CHLA 及其附属机构的制度环境提供了丰富的资源（研究机构和 具有广泛核心的中心），为消化疾病研究培训提供丰富的智力环境，包括 临床研究方法的硕士水平培训，以及专门的实习导师活动，包括年度 由研究员主持的研讨会、每两周一次的工作进展会议以及每月的期刊俱乐部。此外，本次培训 该计划在洛杉矶的多民族环境中进行，为学生提供了独特的教育机会 研究少数民族人群的肝脏疾病。 T32 培训计划的最终目标是为 GI 做好准备 受训者担任教员级别的职位并成功竞争跨学科的独立研究经费 一系列转化性肝病研究，旨在解决肝脏疾病的重大负担 美国和全球。

项目成果

A Case of Pediatric Alcohol-Associated Hepatitis Evaluated for Liver Transplant Listing.

• DOI: 10.1097/pg9.0000000000000311
• 发表时间: 2023-05
• 期刊: JPGN reports

Elevated liver enzymes: unusual presentation of anti-MDA5 antibody-associated juvenile dermatomyositis.

肝酶升高：抗 MDA5 抗体相关幼年皮肌炎的异常表现。

• DOI: 10.55563/clinexprheumatol/25znui
• 发表时间: 2024
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Yi,BelinaY;Marrs,Joshua;Schenker,Rachel;Suddock,Jolee;Cotter,JenniferA;Cidon,Michal
• 通讯作者: Cidon,Michal

Recurrent Rectal Prolapse Successfully Treated With Polyethylene Glycol.

• DOI: 10.1097/pg9.0000000000000380
• 发表时间: 2023-11
• 期刊: JPGN reports