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Translational Research Training in Gastroenterology and Hepatology

胃肠病学和肝病学转化研究培训

基本信息

批准号：
10396477
负责人：
Maria Teresa Abreu
金额：
$ 17.29万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10396477
关键词：
Gastroenterology Hepatology Research Training Translational Research

项目摘要

PROJECT SUMMARY This is a new application for the purpose of establishing a training program to provide systematic, multidisciplinary postdoctoral research training in “Translational gastroenterology and hepatology”. Gastrointestinal complaints are the most common reason patients seek medical attention. In many instances, minority patients suffer disproportionately from gastrointestinal or liver diseases and have worse outcomes. Research in gastroenterology and hepatology has made progress to alleviate suffering but translational research that incorporates pathogenetic interrogation, characterization of epidemiologic risk factors, and attention to health care disparities is required to make sustainable and scalable advances. South Florida represents a diverse population that compels the medical and scientific community to study gastrointestinal illnesses that affect them and to train physicians and scientists who will implement their discoveries. Among the diseases affecting the South Florida population and for which prevention or precision-targeted therapy needs to be developed are inflammatory bowel diseases (IBD), viral hepatitis, pancreatic disorders, colon cancer and hepatocellular cancer. In addition to the needs of our community, we have an obligation to train a diverse group of physicians and scientists. Our post-doctoral trainees represent a culturally, ethnically diverse group that is currently under-represented as NIH funded investigators. The trainees will be individuals with a MD, PhD or MD/PhD degree committed to a research career in the broad field of digestive health sciences. The framework for this research is our rich resource of laboratory-based and community-based interventions to study gastrointestinal and liver-related illnesses. The training program has two tracks: 1) Basic/Translational Science Research track, or 2) a Health Disparity and Outcomes Research track. In both tracks, trainees will spend 24 months under the direction of one or two of the faculty mentors. In either track, trainees may address one of three training themes: inflammation, regeneration, or health intervention to reduce disparities. These themes represent current research strengths within the digestive diseases research community at the University of Miami Miller School of Medicine (UMMSOM) and are based on current collaborations between our participating mentors. The support of this training grant program will create the infrastructure to train two to three post-doctoral fellows per year resulting in 6 positions on an ongoing basis for both post-doctoral MD and PhD fellows. The individually customized and didactic nature of our program will allow several trainees to take courses. In some cases, trainees may apply these courses towards future advanced degrees or certificates (e.g. Master in Public Health, Master in Biomedical Engineering, Master in Clinical Investigation). Our training grant activities are coordinated within the UMMSOM, which is a global, interdisciplinary network focused on scientific discovery and solutions involving faculty from the departments of Medicine, Pediatrics, Biochemistry and Molecular Biology, Cell Biology, Surgery and the Hussman Institute for Human Genomics.

项目总结这是一个新的申请，目的是建立一个培训计划，提供系统的， “翻译胃肠病和肝病”的多学科博士后研究培训。胃肠道不适是患者寻求医疗服务的最常见原因。在许多情况下，少数族裔患者患有胃肠道或肝脏疾病的比例更高，结果更差。胃肠病和肝病的研究在减轻痛苦方面取得了进展，但翻译研究这包括病原学询问、流行病学危险因素的特征以及对要取得可持续和可扩展的进展，就需要卫生保健差距。南佛罗里达州代表着一个多样化的人群，迫使医学界和科学界研究胃肠道疾病影响他们，并培训将实施他们的发现的医生和科学家。在这些疾病中影响南佛罗里达州人口，需要对其进行预防或精确靶向治疗罹患炎症性肠病(IBD)、病毒性肝炎、胰腺疾病、结肠癌和肝细胞癌。除了满足社会的需要外，我们还有义务培训不同的群体内科医生和科学家。我们的博士后实习生代表了一个文化、种族多元化的群体，目前作为NIH资助的调查人员代表不足。受训者将是拥有医学博士、博士学位或医学博士学位致力于广泛的消化健康科学领域的研究。该框架因为这项研究是我们丰富的实验室和社区干预研究的资源胃肠道和肝脏相关疾病。培训计划有两个方面：1)基础/翻译科学研究跟踪，或2)健康差距和结果研究跟踪。在这两个轨道上，实习生将花费24小时在一两位教职员工导师的指导下工作了几个月。在任一途径中，受训人员可通过以下方式之一进行培训三个培训主题：炎症、再生或健康干预，以减少差距。这些主题代表迈阿密大学消化系统疾病研究界目前的研究优势米勒医学院(UMMSOM)和我们目前参与的合作导师。这一培训资助计划的支持将建立基础设施，以培训两到三名博士后每年设立6个博士后和博士后研究员职位。这个我们计划的个性化和说教性质将允许多名学员参加课程。在一些在某些情况下，学员可以将这些课程应用于未来的高级学位或证书(例如公共硕士健康，生物医学工程硕士，临床调查硕士)。我们的培训资助活动包括在UMMSOM内协调，UMMSOM是一个全球跨学科网络，专注于科学发现和来自医学、儿科、生物化学和分子生物学系的教职员工参与的解决方案，细胞生物学、外科和赫斯曼人类基因组学研究所。