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Translational Research Training in Gastroenterology and Hepatology

胃肠病学和肝病学转化研究培训

基本信息

批准号：
10396477
负责人：
Maria Teresa Abreu
金额：
$ 17.29万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10396477
关键词：
Gastroenterology Hepatology Research Training Translational Research

项目摘要

PROJECT SUMMARY This is a new application for the purpose of establishing a training program to provide systematic, multidisciplinary postdoctoral research training in “Translational gastroenterology and hepatology”. Gastrointestinal complaints are the most common reason patients seek medical attention. In many instances, minority patients suffer disproportionately from gastrointestinal or liver diseases and have worse outcomes. Research in gastroenterology and hepatology has made progress to alleviate suffering but translational research that incorporates pathogenetic interrogation, characterization of epidemiologic risk factors, and attention to health care disparities is required to make sustainable and scalable advances. South Florida represents a diverse population that compels the medical and scientific community to study gastrointestinal illnesses that affect them and to train physicians and scientists who will implement their discoveries. Among the diseases affecting the South Florida population and for which prevention or precision-targeted therapy needs to be developed are inflammatory bowel diseases (IBD), viral hepatitis, pancreatic disorders, colon cancer and hepatocellular cancer. In addition to the needs of our community, we have an obligation to train a diverse group of physicians and scientists. Our post-doctoral trainees represent a culturally, ethnically diverse group that is currently under-represented as NIH funded investigators. The trainees will be individuals with a MD, PhD or MD/PhD degree committed to a research career in the broad field of digestive health sciences. The framework for this research is our rich resource of laboratory-based and community-based interventions to study gastrointestinal and liver-related illnesses. The training program has two tracks: 1) Basic/Translational Science Research track, or 2) a Health Disparity and Outcomes Research track. In both tracks, trainees will spend 24 months under the direction of one or two of the faculty mentors. In either track, trainees may address one of three training themes: inflammation, regeneration, or health intervention to reduce disparities. These themes represent current research strengths within the digestive diseases research community at the University of Miami Miller School of Medicine (UMMSOM) and are based on current collaborations between our participating mentors. The support of this training grant program will create the infrastructure to train two to three post-doctoral fellows per year resulting in 6 positions on an ongoing basis for both post-doctoral MD and PhD fellows. The individually customized and didactic nature of our program will allow several trainees to take courses. In some cases, trainees may apply these courses towards future advanced degrees or certificates (e.g. Master in Public Health, Master in Biomedical Engineering, Master in Clinical Investigation). Our training grant activities are coordinated within the UMMSOM, which is a global, interdisciplinary network focused on scientific discovery and solutions involving faculty from the departments of Medicine, Pediatrics, Biochemistry and Molecular Biology, Cell Biology, Surgery and the Hussman Institute for Human Genomics.

项目概要这是一个新的应用程序，旨在建立一个培训计划，以提供系统的、 “转化胃肠病学和肝病学”多学科博士后研究培训。胃肠道不适是患者就医的最常见原因。在许多情况下，少数患者不成比例地患有胃肠道或肝脏疾病，并且预后较差。胃肠病学和肝病学研究在减轻痛苦方面取得了进展，但转化研究其中包括发病机制询问、流行病学危险因素的表征以及对要取得可持续和可扩展的进步，就需要消除医疗保健差异。南佛罗里达州代表多样化的人群迫使医学界和科学界研究胃肠道疾病影响他们并培训将实施他们的发现的医生和科学家。疾病当中影响南佛罗里达州人口，需要进行预防或精准靶向治疗已发展为炎症性肠病（IBD）、病毒性肝炎、胰腺疾病、结肠癌和肝细胞癌。除了我们社区的需求之外，我们还有义务培训多元化的群体的医生和科学家。我们的博士后学员代表了一个文化、种族多元化的群体目前，美国国立卫生研究院 (NIH) 资助的研究人员代表性不足。受训者将是拥有医学博士、博士学位或医学博士/博士学位致力于消化健康科学广泛领域的研究事业。框架对于这项研究，我们有丰富的基于实验室和社区的干预研究资源胃肠道和肝脏相关疾病。培训计划有两个方向：1）基础/转化科学研究轨道，或 2) 健康差距和结果研究轨道。在这两个轨道上，学员将花费 24 在一两个导师的指导下进行几个月的学习。在任一轨道中，受训者都可以解决其中一个问题三个培训主题：炎症、再生或减少差异的健康干预。这些主题代表迈阿密大学消化疾病研究界当前的研究优势米勒医学院 (UMMSOM) 并基于我们参与项目之间当前的合作导师。该培训资助计划的支持将为培训两到三名博士后奠定基础每年产生 6 个博士后 MD 和博士研究员职位。这我们的课程具有个性化定制和教学性质，允许多名学员参加课程。在一些在这种情况下，学员可以将这些课程应用于未来的高级学位或证书（例如公共硕士健康、生物医学工程硕士、临床研究硕士）。我们的培训资助活动是在 UMMSOM 内进行协调，UMMSOM 是一个全球性的跨学科网络，专注于科学发现和涉及医学、儿科、生物化学和分子生物学系教师的解决方案，细胞生物学、外科和哈斯曼人类基因组学研究所。