Translational Research Training in Gastroenterology and Hepatology

项目摘要 这是一个新的应用程序，旨在建立培训计划，以提供系统的、 多学科博士后研究培训“转化胃肠病学和肝病学”。 胃肠道疾病是患者就医的最常见原因。在许多情况下， 少数患者不成比例地患有胃肠道或肝脏疾病，结果更糟。 胃肠病学和肝病学的研究在减轻痛苦方面取得了进展， 包括病因询问、流行病学危险因素的表征，以及对 要取得可持续和可扩展的进展，就需要消除保健方面的差距。南佛罗里达代表了 多样化的人口，迫使医学和科学界研究胃肠道疾病， 影响他们，并培训医生和科学家谁将实施他们的发现。在这些疾病中， 影响南佛罗里达人口，需要预防或精确靶向治疗 发展的是炎症性肠病（IBD），病毒性肝炎，胰腺疾病，结肠癌和 肝癌除了我们社区的需要，我们还有义务培养一个多元化的群体 医生和科学家。我们的博士后学员代表了一个文化，种族多元化的群体， 目前作为NIH资助的研究人员代表不足。受训人员将是具有医学博士、博士或 MD/PhD学位致力于消化健康科学广泛领域的研究事业。框架 因为这项研究是我们丰富的资源，以实验室为基础，以社区为基础的干预研究 胃肠道和肝脏相关疾病。该培训计划有两个轨道：1）基础/转化科学 研究轨道，或2）健康差距和结果研究轨道。在这两个轨道上，学员将花费24 在一两位导师的指导下学习几个月。在任何一个轨道，学员可以解决其中一个 三个培训主题：炎症，再生，或健康干预，以减少差距。这些主题 代表了迈阿密大学消化系统疾病研究界目前的研究优势 米勒医学院（UMMSOM），并基于我们的参与之间的当前合作 导师这项培训补助金计划的支持将为培养两到三名博士后创造基础设施 研究员每年产生6个职位，在持续的基础上，为博士后MD和博士研究员。的 个别定制和教学性质，我们的计划将允许几个学员参加课程。在一些 在某些情况下，学员可以申请这些课程，以获得未来的高级学位或证书（例如公共管理硕士 健康，生物医学工程硕士，临床研究硕士）。我们的培训补助金活动是 UMMSOM是一个全球性的跨学科网络，专注于科学发现， 解决方案涉及来自医学，儿科，生物化学和分子生物学系的教师， 细胞生物学、外科学和胡斯曼人类基因组学研究所。

PROJECT SUMMARY This is a new application for the purpose of establishing a training program to provide systematic, multidisciplinary postdoctoral research training in “Translational gastroenterology and hepatology”. Gastrointestinal complaints are the most common reason patients seek medical attention. In many instances, minority patients suffer disproportionately from gastrointestinal or liver diseases and have worse outcomes. Research in gastroenterology and hepatology has made progress to alleviate suffering but translational research that incorporates pathogenetic interrogation, characterization of epidemiologic risk factors, and attention to health care disparities is required to make sustainable and scalable advances. South Florida represents a diverse population that compels the medical and scientific community to study gastrointestinal illnesses that affect them and to train physicians and scientists who will implement their discoveries. Among the diseases affecting the South Florida population and for which prevention or precision-targeted therapy needs to be developed are inflammatory bowel diseases (IBD), viral hepatitis, pancreatic disorders, colon cancer and hepatocellular cancer. In addition to the needs of our community, we have an obligation to train a diverse group of physicians and scientists. Our post-doctoral trainees represent a culturally, ethnically diverse group that is currently under-represented as NIH funded investigators. The trainees will be individuals with a MD, PhD or MD/PhD degree committed to a research career in the broad field of digestive health sciences. The framework for this research is our rich resource of laboratory-based and community-based interventions to study gastrointestinal and liver-related illnesses. The training program has two tracks: 1) Basic/Translational Science Research track, or 2) a Health Disparity and Outcomes Research track. In both tracks, trainees will spend 24 months under the direction of one or two of the faculty mentors. In either track, trainees may address one of three training themes: inflammation, regeneration, or health intervention to reduce disparities. These themes represent current research strengths within the digestive diseases research community at the University of Miami Miller School of Medicine (UMMSOM) and are based on current collaborations between our participating mentors. The support of this training grant program will create the infrastructure to train two to three post-doctoral fellows per year resulting in 6 positions on an ongoing basis for both post-doctoral MD and PhD fellows. The individually customized and didactic nature of our program will allow several trainees to take courses. In some cases, trainees may apply these courses towards future advanced degrees or certificates (e.g. Master in Public Health, Master in Biomedical Engineering, Master in Clinical Investigation). Our training grant activities are coordinated within the UMMSOM, which is a global, interdisciplinary network focused on scientific discovery and solutions involving faculty from the departments of Medicine, Pediatrics, Biochemistry and Molecular Biology, Cell Biology, Surgery and the Hussman Institute for Human Genomics.