Translational Research Training in Gastroenterology and Hepatology

胃肠病学和肝病学转化研究培训

• 批准号: 9906212
• 负责人: Maria Teresa Abreu
• 金额: $ 9.88万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906212
• 关键词: Gastroenterology; Hepatology; Research Training; Translational Research

PROJECT SUMMARY This is a new application for the purpose of establishing a training program to provide systematic, multidisciplinary postdoctoral research training in “Translational gastroenterology and hepatology”. Gastrointestinal complaints are the most common reason patients seek medical attention. In many instances, minority patients suffer disproportionately from gastrointestinal or liver diseases and have worse outcomes. Research in gastroenterology and hepatology has made progress to alleviate suffering but translational research that incorporates pathogenetic interrogation, characterization of epidemiologic risk factors, and attention to health care disparities is required to make sustainable and scalable advances. South Florida represents a diverse population that compels the medical and scientific community to study gastrointestinal illnesses that affect them and to train physicians and scientists who will implement their discoveries. Among the diseases affecting the South Florida population and for which prevention or precision-targeted therapy needs to be developed are inflammatory bowel diseases (IBD), viral hepatitis, pancreatic disorders, colon cancer and hepatocellular cancer. In addition to the needs of our community, we have an obligation to train a diverse group of physicians and scientists. Our post-doctoral trainees represent a culturally, ethnically diverse group that is currently under-represented as NIH funded investigators. The trainees will be individuals with a MD, PhD or MD/PhD degree committed to a research career in the broad field of digestive health sciences. The framework for this research is our rich resource of laboratory-based and community-based interventions to study gastrointestinal and liver-related illnesses. The training program has two tracks: 1) Basic/Translational Science Research track, or 2) a Health Disparity and Outcomes Research track. In both tracks, trainees will spend 24 months under the direction of one or two of the faculty mentors. In either track, trainees may address one of three training themes: inflammation, regeneration, or health intervention to reduce disparities. These themes represent current research strengths within the digestive diseases research community at the University of Miami Miller School of Medicine (UMMSOM) and are based on current collaborations between our participating mentors. The support of this training grant program will create the infrastructure to train two to three post-doctoral fellows per year resulting in 6 positions on an ongoing basis for both post-doctoral MD and PhD fellows. The individually customized and didactic nature of our program will allow several trainees to take courses. In some cases, trainees may apply these courses towards future advanced degrees or certificates (e.g. Master in Public Health, Master in Biomedical Engineering, Master in Clinical Investigation). Our training grant activities are coordinated within the UMMSOM, which is a global, interdisciplinary network focused on scientific discovery and solutions involving faculty from the departments of Medicine, Pediatrics, Biochemistry and Molecular Biology, Cell Biology, Surgery and the Hussman Institute for Human Genomics.

项目摘要 这是一个新的应用程序，目的是建立培训计划，以提供系统的， 多学科的博士后研究培训“转化胃肠病和肝病学”。 胃肠道抱怨是患者寻求医疗护理的最常见原因。在许多情况下， 少数族裔患者因胃肠道或肝脏疾病而遭受不成比例的痛苦，并且预后较差。 胃肠病学和肝病学的研究取得了进步，以减轻痛苦，但翻译了研究 结合了致病性审讯，流行病学风险因素的表征以及对 需要进行医疗保健分布来实现可持续和可扩展的进步。南佛罗里达代表 迫使医学和科学界研究胃肠道疾病的人群多样化 影响他们，并培训将实施发现的医生和科学家。在疾病中 影响南佛罗里达州的人口，并且需要预防或精确靶向治疗 发达的是炎症性肠病（IBD），病毒肝炎，胰腺疾病，结肠癌和 肝细胞癌。除了社区的需求外，我们还有义务培训一个多样化的小组 医师和科学家。我们的博士后学员代表了一个文化，种族多元化的群体 目前作为NIH资助的调查人员的代表性不足。培训将是拥有MD，PhD或 医学博士/博士学位致力于从事消化健康科学领域的研究职业。框架 对于这项研究，是我们丰富的基于实验室和基于社区的干预措施的资源 胃肠道和与肝有关的疾病。培训计划有两条曲目：1）基础/转化科学 研究轨道，或2）健康差异和结果研究轨道。在这两个曲目中，学员将花费24 在一两个教师导师的指导下，几个月。在任何一条轨道上，学员都可以谈论 三个培训主题：炎症，再生或健康干预以减少分布。这些主题 代表迈阿密大学消化系统疾病研究社区内的当前研究优势 米勒医学院（UMMSOM），并基于我们参与的当前合作 导师。该培训补助计划的支持将创建基础设施，以培训两到三个博士后 每年的研究员每年导致医学博士和博士学位研究员的持续6个职位。这 在某些单独定制和教学性质中，我们的计划将允许几名学员参加课程。 案例，受训者可以将这些课程应用于未来的高级学位或证书（例如，公共硕士 健康，生物医学工程硕士，临床研究硕士）。我们的培训赠款活动是 在脐带中协调，这是一个全球跨学科网络，重点是科学发现和 涉及医学，儿科，生物化学和分子生物学系的教师的解决方案， 细胞生物学，手术和侯赛因人类基因组学研究所。