Clinical and Translational Science Core

项目总结（临床和翻译科学核心） 世卫组织的“终结结核病战略”将需要新型结核病疫苗、药物和诊断方法，同时沿着 临床研究方法和建模，临床研究人员的新干部，加强国内和 国际合作和获取生物标本。华盛顿大学（UW）在以下方面表现出色： 开展临床流行病学、临床试验、实施科学和疾病建模研究， 还在结核病流行的国家发展强有力的全球卫生项目和伙伴关系。临床和 转化科学核心（“CTSC”）将教育和培训新的和早期的研究人员，包括人 在结核病流行国家工作的人，以及来自代表性不足的少数群体的个人， 结核病临床研究气候技术服务中心将与其他SEA-TRAC核心协调， 提供专业知识，并聘请非结核病研究人员，他们可能带来新的观点和先进的方法 结核病研究。CTSC将利用现有的生物储存库促进结核病研究， 初步数据使用了庞大的华盛顿大学研究网络，包括在拉丁美洲，撒哈拉以南非洲， 非洲和亚洲。CTSC将为广泛的临床研究主题提供专业知识， 在资源、服务和培训方面共享研究支持，并通过以下措施加强结核病临床研究 国内和国际合作，通过三个具体目标：（1）加强临床和转化 通过临床科学方法的培训和咨询以及支持地方合作开展结核病研究; (2)加强结核病临床研究，发展和扩大与国家和国际组织的伙伴关系， 合作者进行结核病的临床和转化研究;和（3）目标3。培育和催化 与研究者合作，建立队列，强大的临床数据库和生物标本， 推进基础、转化和临床结核病研究。CTSC还将维持一周的密集 高级结核病研究夏季课程。总的来说，气候技术服务中心将促进东南欧-TRAC 调查人员和授权调查人员，这将导致更富有成效和更有效的研究，增加 在产生的试点研究数据，以及更多的合作结核病赠款提交超过5年的时间。

PROJECT SUMMARY (CLINICAL AND TRANSLATIONAL SCIENCE CORE) The WHO’s “End TB Strategy” will require novel TB vaccines, drugs, and diagnostics, along with advances in clinical research methods and modeling, a new cadre of clinical researchers, strengthened domestic and international collaborations, and access to biospecimens. The University of Washington (UW) excels in conducting research in clinical epidemiology, clinical trials, implementation science, and disease modeling, while also developing strong global health programs and partnerships in TB-endemic countries. The Clinical and Translational Science Core (“CTSC”) will educate and train new and early-stage investigators, including people working in TB-endemic countries, and individuals from underrepresented minority groups, in critical areas of clinical TB research. The CTSC will coordinate with the other SEA-TRAC Cores to leverage the multi-disciplinary expertise available and engage non-TB investigators who may bring novel perspectives and advanced methods to TB research. The CTSC will leverage existing biorepositories to catalyze TB research and generate preliminary data using the vast UW research network that includes field sites in Latin America, sub-Saharan Africa, and Asia. The CTSC will be to provide expertise for a broad array of clinical research topics, provide shared research support for resources, services and training, and to strengthen TB clinical research through domestic and international collaborations through three specific aims: (1) to strengthen clinical and translational TB research through training and consultation in clinical science methodology and support of local collaborations; (2) to strengthen TB clinical research by developing and expanding partnerships with national and international collaborators conducting clinical and translational research in TB; and (3) Aim 3. To foster and catalyze collaborations with investigators with established cohorts, robust clinical databases, and biospecimens for advancing basic, translation, and clinical TB research. The CTSC will also maintain an intensive one-week advanced TB research summer course. Overall, the CTSC will foster collaborations between SEA-TRAC investigators and authorizing investigators, which will lead to more productive and efficient research, an increase in generated pilot study data, and more collaborative TB grant submissions over a 5-year period.