Clinical and Translational Science Core

临床和转化科学核心

• 批准号: 10425950
• 负责人: David J. Horne
• 金额: $ 22.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425950
• 关键词: Africa South of the Sahara; Area; Asia; Biological; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Collection; Consult; Consultations; Country; Data; Databases; Diagnostic; Disease model; Educational process of instructing; Faculty; Fostering; Goals; Grant; Individual; International; Latin America; Lead; Mentors; Methodology; Methods; Minority Groups; Modeling; Outcome; Persons; Pharmaceutical Preparations; Pilot Projects; Protocols documentation; Public Health; Research; Research Activity; Research Methodology; Research Personnel; Research Support; Resources; Series; Services; Site; Specimen; Structure; Training; Translational Research; Translations; Travel; Tuberculosis; Tuberculosis Vaccines; Underrepresented Minority; Universities; Vaccines; Washington; biobank; clinical database; clinical epidemiology; cohort; disease transmission; global health; graduate student; implementation science; meetings; multidisciplinary; novel; programs; prospective; sample collection; summer research; working group

PROJECT SUMMARY (CLINICAL AND TRANSLATIONAL SCIENCE CORE) The WHO’s “End TB Strategy” will require novel TB vaccines, drugs, and diagnostics, along with advances in clinical research methods and modeling, a new cadre of clinical researchers, strengthened domestic and international collaborations, and access to biospecimens. The University of Washington (UW) excels in conducting research in clinical epidemiology, clinical trials, implementation science, and disease modeling, while also developing strong global health programs and partnerships in TB-endemic countries. The Clinical and Translational Science Core (“CTSC”) will educate and train new and early-stage investigators, including people working in TB-endemic countries, and individuals from underrepresented minority groups, in critical areas of clinical TB research. The CTSC will coordinate with the other SEA-TRAC Cores to leverage the multi-disciplinary expertise available and engage non-TB investigators who may bring novel perspectives and advanced methods to TB research. The CTSC will leverage existing biorepositories to catalyze TB research and generate preliminary data using the vast UW research network that includes field sites in Latin America, sub-Saharan Africa, and Asia. The CTSC will be to provide expertise for a broad array of clinical research topics, provide shared research support for resources, services and training, and to strengthen TB clinical research through domestic and international collaborations through three specific aims: (1) to strengthen clinical and translational TB research through training and consultation in clinical science methodology and support of local collaborations; (2) to strengthen TB clinical research by developing and expanding partnerships with national and international collaborators conducting clinical and translational research in TB; and (3) Aim 3. To foster and catalyze collaborations with investigators with established cohorts, robust clinical databases, and biospecimens for advancing basic, translation, and clinical TB research. The CTSC will also maintain an intensive one-week advanced TB research summer course. Overall, the CTSC will foster collaborations between SEA-TRAC investigators and authorizing investigators, which will lead to more productive and efficient research, an increase in generated pilot study data, and more collaborative TB grant submissions over a 5-year period.

项目摘要(临床和转化科学核心) 世界卫生组织的“结束结核病战略”将需要新的结核病疫苗、药物和诊断方法，以及在以下方面的进展 临床研究方法和模式，临床研究人员的新干部，加强国内和 国际合作，以及获得生物质谱仪。华盛顿大学(UW)在 开展临床流行病学、临床试验、实施科学和疾病模型方面的研究，同时 还在结核病流行国家发展强有力的全球卫生方案和伙伴关系。临床和医学研究 翻译科学核心(“CTSC”)将教育和培训新的和早期的调查人员，包括 在结核病流行国家工作，以及来自代表不足的少数群体的个人，在关键领域 临床结核病研究。CTSC将与SEA-TRAC的其他核心协调，以利用多学科 提供专业知识，并聘用可能带来新视角和先进方法的非结核病研究人员 结核病研究。CTSC将利用现有的生物储存库来催化结核病研究并产生 使用庞大的华盛顿大学研究网络的初步数据，该网络包括拉丁美洲、撒哈拉以南地区的现场 非洲和亚洲。CTSC将为广泛的临床研究课题提供专业知识，提供 共享研究支持资源、服务和培训，并通过以下方式加强结核病临床研究 通过三个具体目标进行国内和国际合作：(1)加强临床和翻译 通过临床科学方法方面的培训和咨询进行结核病研究，并支持地方合作； (2)通过发展和扩大与国家和国际的伙伴关系，加强结核病临床研究 合作者在结核病方面进行临床和转化性研究；以及(3)目标3.促进和催化 与研究人员合作，建立队列，强大的临床数据库和生物样品 推进基础、翻译和临床结核病研究。CTSC还将维持一周的密集活动 结核病研究高级暑期课程。总体而言，CTSC将促进SEA-TRAC之间的合作 调查人员和授权调查人员，这将导致更多成果和更有效率的研究，增加 在生成的试点研究数据中，以及在5年内提交更多合作的结核病赠款。